Therapeutic Drug Monitoring of 6 New-Generation Antiseizure Medications Using a Mass Spectrometry Method: Analysis of 2-Year Experience in a Large Cohort of Korean Epilepsy Patients
CONCLUSIONS.—: A simple and rapid LC-MS/MS method for TDM of 6 ASMs was developed and successfully applied to clinical practice. This large-scale TDM data could help establish an effective monitoring strategy for these drugs.PMID:38576184 | DOI:10.5858/arpa.2023-0386-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 5, 2024 Category: Laboratory Medicine Authors: Sang-Mi Kim Won Young Heo Hyeonju Oh Eun Yeon Joo Young-Min Shon Seung Bong Hong Soo-Youn Lee Dae-Won Seo Source Type: research
Therapeutic Drug Monitoring of 6 New-Generation Antiseizure Medications Using a Mass Spectrometry Method: Analysis of 2-Year Experience in a Large Cohort of Korean Epilepsy Patients
CONCLUSIONS.—: A simple and rapid LC-MS/MS method for TDM of 6 ASMs was developed and successfully applied to clinical practice. This large-scale TDM data could help establish an effective monitoring strategy for these drugs.PMID:38576184 | DOI:10.5858/arpa.2023-0386-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 5, 2024 Category: Laboratory Medicine Authors: Sang-Mi Kim Won Young Heo Hyeonju Oh Eun Yeon Joo Young-Min Shon Seung Bong Hong Soo-Youn Lee Dae-Won Seo Source Type: research
Therapeutic Drug Monitoring of 6 New-Generation Antiseizure Medications Using a Mass Spectrometry Method: Analysis of 2-Year Experience in a Large Cohort of Korean Epilepsy Patients
CONCLUSIONS.—: A simple and rapid LC-MS/MS method for TDM of 6 ASMs was developed and successfully applied to clinical practice. This large-scale TDM data could help establish an effective monitoring strategy for these drugs.PMID:38576184 | DOI:10.5858/arpa.2023-0386-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 5, 2024 Category: Laboratory Medicine Authors: Sang-Mi Kim Won Young Heo Hyeonju Oh Eun Yeon Joo Young-Min Shon Seung Bong Hong Soo-Youn Lee Dae-Won Seo Source Type: research
Inhibition of resurgent Na < sup > + < /sup > currents by rufinamide
Neuropharmacology. 2024 Jan 14;247:109835. doi: 10.1016/j.neuropharm.2024.109835. Online ahead of print.ABSTRACTNa+ channels are essential for the genesis of action potentials in most neurons. After opening by membrane depolarization, Na+ channels enter a series of inactivated states (e.g. the fast, intermediate, and slow inactivated states; or If, Ii, and Is). The inactivated Na+ channel may recover via the open state upon membrane repolarization, giving rise to "resurgent" Na+ currents which could be critical for densely repetitive or burst discharges. We incubated CHO-K1 cells transfected with human NaV1.7 cDNA and meas...
Source: Neuropharmacology - January 16, 2024 Category: Drugs & Pharmacology Authors: Jian-Lin Chen Chung-Chin Kuo Source Type: research
Copper Dispersed Covalent Organic Framework for Azide –Alkyne Cycloaddition and Fast Synthesis of Rufinamide in Water
An atomically dispersed copper-loaded covalent organic framework Cu(I)-Bpy-COF is synthesized. The highly hydrophilic skeleton, large specific surface area and mesoporous channels endow Cu(I)-Bpy-COF with excellent universality and outstanding catalytic efficiency in water medium for azide –alkyne cycloadditions, regardless of the presence of polar groups and fluorine, nitrogen, sulfur heteroatoms in aromatic/aliphatic reaction substrates. AbstractA crystalline porous bipyridine-based Bpy-COF with a high BET surface area (1864 m2 g−1) and uniform mesopore (4.0 nm) is successfully synthesized from 1,3,5-tris-(4’-...
Source: Small - January 8, 2024 Category: Nanotechnology Authors: Fei Xue,
Jun Zhang,
Zhongcheng Ma,
Zhonggang Wang Tags: Research Article Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: Journal of Physiology and Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: Journal of Physiology and Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: Journal of Physiology and Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: Journal of Physiology and Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: Journal of Physiology and Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
