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Specialty: Cardiology
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Total 109076 results found since Jan 2013.
PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
CONCLUSIONS: Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.PMID:37737016 | DOI:10.1161/CIRCRESAHA.123.322516
Source: Circulation Research - September 22, 2023 Category: Cardiology Authors: Srikanth Perike Francisco J Gonzalez-Gonzalez Issam Abu-Taha Frederick W Damen Laurin M Hanft Ken S Lizama Anahita Aboonabi Andrielle E Capote Yuriana Aguilar-Sanchez Benjamin Levin Zhenbo Han Arvind Sridhar Jacob Grand Jody Martin Joseph G Akar Chad M Wa Source Type: research
Endoscopically Active Ulcerative Colitis Is Associated With Asymptomatic Atherosclerotic Vascular Disease: A Case-Control Study
CONCLUSIONS: Patients with UC with active mucosal inflammation showed a significantly increased odds of asymptomatic femoral or carotid vascular disease when compared with control individuals.PMID:37738567 | DOI:10.1093/ibd/izad217
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Juan Lasa Ezequiel Nazario Gonzalo De Sanctis Mar ía Fernández Recalde Juan Pereira Redondo Juan Monta ñana Fernando Spernanzoni Ignacio Zubiaurre Pablo A Olivera Source Type: research
The prevalence and prognosis of asymptomatic intracranial atherosclerosis in a community-based population: Results based on high-resolution magnetic resonance imaging
CONCLUSIONS: We found that ICAD detected using HR-MRI increases the long-term risk of a first-ever ischemic stroke in a stroke-free population, suggesting that the current primary prevention protocol of stroke awaits further optimization.PMID:37738517 | DOI:10.1111/ene.16057
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Shengde Li Mingyu Tang Dingding Zhang Fei Han Lixin Zhou Ming Yao Mingli Li Liying Cui Shuyang Zhang Bin Peng Zhengyu Jin Yicheng Zhu Jun Ni Source Type: research
Low-density lipoprotein subclasses over the menopausal transition and risk of coronary calcification and carotid atherosclerosis: the SWAN Heart and HDL ancillary studies
CONCLUSIONS: During the MT, women experience significant increases in LDL subclasses found to be related to greater cIMT levels and CAC prevalence. Whether these changes could better predict future risk of hard cardiovascular disease events beyond LDL-C remains a research question to address.PMID:37738035 | DOI:10.1097/GME.0000000000002245
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Samar R El Khoudary Xirun Chen Ziyuan Wang Maria M Brooks Trevor Orchard Sybil Crawford Imke Janssen Susan A Everson-Rose Daniel McConnell Karen Matthews Source Type: research
Assembling the anaerobic gamma-butyrobetaine to TMA metabolic pathway in < em > Escherichia fergusonii < /em > and confirming its role in TMA production from dietary < em > L- < /em > carnitine in murine models
mBio. 2023 Sep 22:e0093723. doi: 10.1128/mbio.00937-23. Online ahead of print.ABSTRACTTrimethylamine-N-oxide (TMAO) is a major pro-atherogenic and pro-thrombotic metaorganismal molecule produced through the initial conversion of the dietary L-carnitine and other precursors into trimethylamine (TMA). We recently identified a dual-microbe anaerobic pathway for the metabolism of L-carnitine into TMA, in which the widely distributed cai operon in Enterobacteriaceae converts L-carnitine into gamma-butyrobetaine (γBB), followed by the degradation of γBB into TMA by the relatively rare gamma-butyrobetaine utilization (gbu) gene...
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Mohammed Dwidar Jennifer A Buffa Zeneng Wang Akeem Santos Aaron N Tittle Xiaoming Fu Adeline M Hajjar Joseph A DiDonato Stanley L Hazen Source Type: research
Non-Calcified Coronary Artery Plaque on Coronary Computed Tomography Angiogram: Prevalence and Significance
CONCLUSIONS: NCP is the initial precursor of calcified plaque and serves as a prominent marker of early coronary atherosclerosis. By detecting NCP during early stages, several measures can be implemented which can alter the evolutionary course of the underlying disease. This can potentially lead to a lower incidence of cardiovascular events.PMID:37736993 | DOI:10.3390/tomography9050140
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Bandar Alyami Matthew Santer Karthik Seetharam Dhivya Velu Eswar Gadde Bansari Patel Yasmin S Hamirani Source Type: research
Sirt6 enhances macrophage lipophagy and improves lipid metabolism disorder by regulating the Wnt1/ β-catenin pathway in atherosclerosis
In this study, ApoE-/-: Sirt6-/- and ApoE-/-: Sirt6Tg mice were used and lipid droplets were analysed via transmission electron microscopy and Bodipy 493/503 staining in vitro. Atherosclerotic plaques in ApoE-/-: Sirt6-/- mice showed greater necrotic cores and lower stability score. Reconstitution of Sirt6 in atherosclerotic mice improved lipid metabolism disorder and prevented the progression of atherosclerosis. Furthermore, macrophages with Ac-LDL intervention showed more lipid droplets and increased expression of adipophilin and PLIN2. Reconstitution of Sirt6 recruited using SNF2H suppressed Wnt1 expression and improved...
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Tingting Wang Zheng Cheng Ran Zhao Jin Cheng He Ren Pengke Zhang Pengyun Liu Qimeng Hao Qian Zhang Xiaolei Yu Dongdong Sun Dongwei Zhang Source Type: research
Female-specific risk factors of parity and menopause age and risk of carotid plaque: the multi-ethnic study of atherosclerosis
CONCLUSION: In a multiethnic cohort, grand multiparity was independently associated with carotid plaque presence and progression. Early menopause, a known risk factor for CVD, was not captured by carotid plaque in this study. These findings may have implications for refining CVD risk assessment in women.PMID:37736349 | PMC:PMC10509453
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Carla P Rodriguez Oluseye Ogunmoroti Anum S Minhas Dhananjay Vaidya Brigitte Kazzi Olatokunbo Osibogun Seamus Whelton Lara C Kovell Colleen M Harrington Michael C Honigberg Ritu Thamman James H Stein Michael D Shapiro Erin D Michos Source Type: research
Human regulatory T cells turn into cytotoxic 'exT < sub > reg < /sub > ' cells in atherosclerosis
Nat Immunol. 2023 Sep 21. doi: 10.1038/s41590-023-01629-4. Online ahead of print.NO ABSTRACTPMID:37735595 | DOI:10.1038/s41590-023-01629-4
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Source Type: research
Circ_0068481 affects the human pulmonary artery smooth muscle cells' progression by miR-361-3p/KLF5 axis
CONCLUSION: Circ_0068481 knockdown ameliorated hypoxia-induced hPASMC proliferation, invasion and migration at least in part through the miR-361-3p/KLF5 axis.PMID:37738301 | DOI:10.1093/ajh/hpad028
Source: American Journal of Hypertension - September 22, 2023 Category: Cardiology Authors: Hai-Rong Li Guan-Liang Chen Xiao-Li Fang Xing-Jiu Cai Rong-Li Xu Dong-Dong Li Zhi-Wei Zhang Source Type: research
Pulse Check - Arterial Health after Preeclampsia
Am J Hypertens. 2023 Sep 20:hpad086. doi: 10.1093/ajh/hpad086. Online ahead of print.NO ABSTRACTPMID:37738220 | DOI:10.1093/ajh/hpad086
Source: American Journal of Hypertension - September 22, 2023 Category: Cardiology Authors: Mohammad A Salameh Andrea G Kattah Source Type: research
Testosterone Replacement Therapy and Cardiovascular Disease: Balancing Safety and Risks in Hypogonadal Men
Curr Cardiol Rep. 2023 Sep 21. doi: 10.1007/s11886-023-01935-1. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and adverse cardiovascular (CV) events. RECENT FINDINGS: A few published studies suggest a link between TRT and CV events. These studies contained flaws, and many other studies reveal a reduction in CV events. Hypogonadism is associated with increased mortality in men with CVD. TRT in hypogonadal men can improve many CVD risk factors, reduce QT interval prolongation, lead to better outcomes in heart failure patients,...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Kelli Blackwell Michele Blackwell Thomas Blackwell Source Type: research
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
bioRxiv. 2023 Sep 7:2023.09.05.556397. doi: 10.1101/2023.09.05.556397. Preprint.ABSTRACTTissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryonic yolk sac, fetal liver or bone marrow. Some of these TRM are known pathogenic participants in congenital and acquired diseases. Myeloablative conditioning and hematopoietic stem cell transplant can replace long-lived brain TRM resulting in clinical improvements in metabolic storage diseases. With the advent of antibody-drug-conjugate (ADC) targeted cell killing as a cell selective means of transplant conditioning, we asses...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Karin Gustafsson Catherine Rhee Vanessa Frodermann Elizabeth W Scadden Dan Li Yoshiko Iwamoto Rahul Palchaudhuri Sharon L Hyzy Anthony E Boitano Matthias Nahrendorf David T Scadden Source Type: research
Development and Characterization of Proteomic Aging Clocks in the Atherosclerosis Risk in Communities (ARIC) Study
We examined their associations with mortality from all-cause, cardiovascular disease (CVD), cancer, and lower respiratory disease (LRD) using Cox proportional hazards regression in all remaining participants irrespective of health. The model was adjusted for chronological age, smoking, body mass index (BMI), and other confounders. The ARIC PACs had a slightly stronger correlation with chronological age than published PACs in healthy participants at each time point. Associations with mortality were similar for the ARIC and published PACs. For late-life and midlife age acceleration for the ARIC PACs, respectively, hazard rat...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Authors Shuo Wang Zexi Rao Rui Cao Anne H Blaes Josef Coresh Corinne E Joshu Benoit Lehallier Pamela L Lutsey James S Pankow Sanaz Sedaghat Weihong Tang Bharat Thyagarajan Keenan A Walker Peter Ganz Elizabeth A Platz Weihua Guan Anna Prizment Source Type: research
The importance of baseline fractional flow reserve to detect significant coronary artery stenosis in different patient populations
CONCLUSION: The baseline FFR value could be used to predict critical coronary stenosis in our patients and had similar value for predicting lesion severity in all the subgroups.PMID:37733043 | DOI:10.5830/CVJA-2023-045
Source: Cardiovascular Journal of Africa - September 21, 2023 Category: Cardiology Authors: Ismet Zengin Alper Karakus Source Type: research
