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Many Researchers and Companies Will Aim to Produce Small Molecule Reprogramming Therapies
The typical path for any program in biomedical research and development is to first demonstrate interesting results in animal studies using forms of genetic engineering or gene therapy, and then find small molecules that adjust the same mechanism. Small molecules are never as good as genetic manipulations, the size of the effect is always smaller, usually much smaller, and there are inevitably side-effects. Small molecule development is much easier to conduct, however, more familiar to investors and regulators and program managers, a well-trodden path. Thus while the future of medicine is gene therapy, in search of large e...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A cardiovascular polypill for secondary stroke prevention in a tertiary centre in Ghana (SMAART): a phase 2 randomised clinical trial
Lancet Glob Health. 2023 Oct;11(10):e1619-e1628. doi: 10.1016/S2214-109X(23)00347-9.ABSTRACTBACKGROUND: A cardiovascular polypill containing generic drugs might facilitate sustained implementation of and adherence to evidence-based treatments, especially in resource-limited settings. However, the impact of a cardiovascular polypill in mitigating atherosclerotic risk among stroke survivors has not been assessed. We aimed to compare a polypill regimen with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke.METHODS: In SMAART, a phase 2 parallel, open-label, assessor-masked, randomised clini...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Fred Stephen Sarfo Jenifer Voeks Sheila Adamu Benedict Apaw Agyei Manolo Agbenorku Nyantakyi Adu-Darko Mercy Adomah Oteng Vida Obese Rexford Adu Gyamfi Nathaniel Adusei Mensah Raelle Tagge Michael Ampofo Samuel Amoabeng Kontoh Samuel Blay Nguah Bruce Ovbi Source Type: research

Federal Funding Cuts Loom for Immunization Programs
Am J Nurs. 2023 Oct 1;123(10):15. doi: 10.1097/01.NAJ.0000979060.62602.d0.ABSTRACTStates may lose up to 10% of their budgets for vaccinations.PMID:37732660 | DOI:10.1097/01.NAJ.0000979060.62602.d0
Source: The American Journal of Nursing - September 21, 2023 Category: Nursing Source Type: research

Standardized nomenclature of oral microorganisms in Chinese: the 2023 update
Zhonghua Kou Qiang Yi Xue Za Zhi. 2023 Sep 20;58:1045-1055. doi: 10.3760/cma.j.cn112144-20230816-00079. Online ahead of print.ABSTRACTOral microbial community, as an important part of human microbial community, is closely related to oral and general health. Oral microbiological research has become the forefront of international microbiological research. Standardized and unified nomenclature for oral microorganisms in Chinese is of great significance to support the development of oral medicine research. Standardized translation of microbial names is the basis for writing canonical and authoritative professional textbooks an...
Source: Shanghai Journal of Stomatology - September 20, 2023 Category: Dentistry Authors: Y Q Li X Peng B Ren F H Yan Y P Pan F Chen W B Du J G Liu Q Feng D Q Yang X J Huang Y H Pan Z Z Huang P H Ding K K Zhang H X Liu X D Zhou Source Type: research

Healthcare IT Regulations – What Needs to Be Added and What Needs to Be Removed
There are a lot of rules and regulations in place in the world of healthcare. These are put into place in order to protect patients and organizations. However, the world of healthcare is constantly changing and evolving as we come up with new ideas and solutions. Have the regulations done the same though? Or are there areas that are missing regulations? Or are there areas in healthcare where past regulations are now too restrictive and are holding us back? In search of answers to these questions, we reached out to our incredibly beautiful Healthcare IT Today Community to see what areas they would add, remove, or update re...
Source: EMR and HIPAA - September 19, 2023 Category: Information Technology Authors: Grayson Miller Tags: Administration Ambulatory C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System LTPAC Regulations 1upHealth 4medica Amanda Heidemann Andrea Mazzoccoli Andrew Norden MD Bill Charnetski Cheryl Cheng Commur Source Type: blogs

Quality Contract for the Prevention of Postoperative Delirium
Anasthesiol Intensivmed Notfallmed Schmerzther. 2023 Sep;58(9):525-539. doi: 10.1055/a-2065-3806. Epub 2023 Sep 19.ABSTRACTDelirium is one of the most common postoperative complications. Delayed initiation of treatment leads to an increased mortality rate within the first 90 days and to an increased need for post-hospital care. Similarly, neurocognitive disorders (NCDs) occur in a quarter of affected patients over the long-term. The use of evidence-based guideline recommendations can reduce incidence rates of delirium, shorten delirium duration, and prevent complications. Implementing delirium management according to evide...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - September 19, 2023 Category: Intensive Care Authors: Fatima Y ürek Ursula Marschall Ursula Gaedigk Sinah Kr üger Moritz H öft Claudia Spies Source Type: research

International responses addressing the under-representation of older people in clinical research
This article provides an overview and critique of the current approaches to the inclusion of older people in clinical research and highlights policy gaps and limitations of current strategies.PMID:37724905 | DOI:10.1111/ajag.13234
Source: Australasian Journal on Ageing - September 19, 2023 Category: Geriatrics Authors: Susan C Markham Justin McNab Kate O'Loughlin Lindy Clemson Source Type: research

Ensuring Fairness in Medical Education Assessment
This study takes a first step in centering the margins as we as medical educators grow our understanding of the dynamics of promoting fairness in assessment. Future studies should explore feedback with intentional inclusion and involvement of diverse students, teachers, and researchers at every stage of the research process from conceptualization through dissemination and application of the new learning. We thank our participants for their time and candor discussing this sensitive topic and the Group on Educational Affairs for funding our work. Thank you for your time and attention and the focus that you’ll put on th...
Source: Academic Medicine Blog - September 18, 2023 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Academic Medicine podcast assessment equity Macy Foundation medical education Source Type: blogs

Ponderings on Peer Review: Part 3. Grant Critiques
The objective of stage 1 of the process is to establish the scientific merit of the grant proposal. For that phase, I discuss grant review panels, reviewer qualifications and responsibilities, how reviewers are identified and selected, pre-review meeting activities, activities during the review panel meeting, grant review criteria and scoring scales, and post-meeting activities. I also note 2 mechanisms that provide "pre-peer review" advice and recommendations for grant applications under development. I then describe the events associated with stage 2 of the peer review process in which grant funding agencies consider appl...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Douglas R Seals Source Type: research

Bacillus Calmette-Gu érin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial
EClinicalMedicine. 2023 Sep 11;64:102203. doi: 10.1016/j.eclinm.2023.102203. eCollection 2023 Oct.ABSTRACTBACKGROUND: Recurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether the bacille Calmette-Guérin (BCG) vaccine can attenuate cold sore recurrences through off-target immunomodulatory effects.METHODS: In this nested randomised controlled trial within the multicentre, phase 3 BRACE trial, 6828 healthcare workers were randomised in 36 sites in Australia, the Netherlands, Spain, the United Kingdom and Brazil, to receive BCG-Denmark ...
Source: Herpes - September 18, 2023 Category: Infectious Diseases Authors: Laure F Pittet Cecilia L Moore Ellie McDonald Simone Barry Marc Bonten John Campbell Julio Croda Margareth Dalcolmo Andrew Davidson Mark W Douglas Kaya Gardiner Amanda Gwee Bruno Jardim Marcus V G Lacerda Michaela Lucas David J Lynn Laurens Manning Robert Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

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