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U.S. Primary Care Provider Needs: An Analysis of Workforce Projections and Policy Implications
Policy Polit Nurs Pract. 2023 Aug 21:15271544231190606. doi: 10.1177/15271544231190606. Online ahead of print.ABSTRACTThe primary care (PC) physician workforce has consistently been projected as requiring additional numbers to meet the needs of the U.S. The Health Resources and Service Administration (HRSA) has reported the PC nurse practitioner (NP) workforce to be 90,000 NPs more than required to meet the PC needs of the U.S. With both clinician types contributing to the PC workforce in the country, it is difficult to understand such an oversupply of NPs with continued deficit in PC physicians. The purpose of this study ...
Source: Policy, Politics, and Nursing Practice - August 22, 2023 Category: Nursing Authors: Jana Zwilling Barbara Wise Christine Pintz Mary Beth Bigley Brenda Douglass Tracie W Kirkland Stefanie La Manna Donna Lynch-Smith Sheryl L Mitchell Sharon L Stager Julia Steed Source Type: research
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Development of Two Korean IACUC Guidance Documents to Foster Implementation of the Three Rs
Altern Lab Anim. 2023 Aug 20:2611929231194309. doi: 10.1177/02611929231194309. Online ahead of print.ABSTRACTIn Korea, Institutional Animal Care and Use Committees (IACUCs) have been legally required to apply the Three Rs principles (i.e. replacement, reduction and refinement) and undertake the ethical review of animal study protocols, since 2008. According to Korean law, each IACUC is required to appoint at least one lay member recommended by a non-governmental animal protection organisation, who participates in the ethical review process as part of this role. Despite the importance of the Three Rs and the ethical review ...
Source: Alternatives to Laboratory Animals : ATLA - August 21, 2023 Category: Research Authors: Gwi Hyang Lee Heui-Jin Kim Young-Shin Joo Seung Yeon Kim Barney Reed Lynette A Hart Byung In Choe Source Type: research
Intermediate endpoints as surrogates for outcomes in cancer immunotherapy: a systematic review and meta-analysis of phase 3 trials
EClinicalMedicine. 2023 Aug 9;63:102156. doi: 10.1016/j.eclinm.2023.102156. eCollection 2023 Sep.ABSTRACTBACKGROUND: Cancer immunotherapy shows unique efficacy kinetics that differs from conventional treatment. These characteristics may lead to the prolongation of trial duration, hence reliable surrogate endpoints are urgently needed. We aimed to systematically evaluate the study-level performance of commonly reported intermediate clinical endpoints for surrogacy in cancer immunotherapy.METHODS: We searched the Embase, PubMed, and Cochrane databases, between database inception and October 18, 2022, for phase 3 randomised t...
Source: Cancer Control - August 21, 2023 Category: Cancer & Oncology Authors: Zhishan Zhang Qunxiong Pan Mingdong Lu Bin Zhao Source Type: research
