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Pneumatosis cystoides intestinalis mimicking free intraabdominal air following chemotherapy for relapsed acute myeloblastic leukemia in a transplanted neutropenic child: a case report
CONCLUSIONS: PI is an uncommon complication, and direct radiography/computed tomography scans are very helpful in making the diagnosis in suspicious cases. PI, should be kept in mind, especially in transplanted or relapsed leukemia patients receiving intensive chemotherapy.PMID:37661686 | DOI:10.24953/turkjped.2023.116
Source: The Turkish Journal of Pediatrics - September 4, 2023 Category: Pediatrics Authors: Utku Ayg üneş Barbaros Şahin Karagün İlgen Şaşmaz Kamuran Tutu ş Önder Özden B ülent Antmen Source Type: research
Malignant hypercalcemia revealing a diffuse large B ‐cell lymphoma in a patient with a previous diagnosis of chronic myelomonocytic leukemia: An uncommon hematological coexistence
Key Clinical MessageA 76-year-old patient previously admitted to the cardiology department for replacement of a right ventricular lead on a double-chamber pacemaker was admitted to the internal medicine department 15 days after for bronchopneumopathy. His past medical history was relevant for Type 2 diabetes mellitus, heart failure due to dilated hypokinetic heart disease, transcatheter aortic valve implantation (TAVI), and chronic myelomonocytic leukemia (CMML-0) diagnosed in 2021. Twenty-four hours after ad mission, the patient's general condition deteriorated abruptly, with the onset of drowsiness and psychomotor ret...
Source: Clinical Case Reports - September 4, 2023 Category: General Medicine Authors: Alpha Oumar Diallo,
Amelie Marcou,
J érémie Lespinasse,
Zaida Cordoba‐Sosa,
Emmanuel Andrès,
Léa Docquier,
Noel Lorenzo‐Villalba Tags: CASE REPORT Source Type: research
Potential applications of using tissue-specific EVs in targeted therapy and vaccinology
In conclusion, recently published works have shown that EVs could become biomarkers and modern vehicles of advanced drug forms.PMID:37660644 | DOI:10.1016/j.biopha.2023.115308
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 3, 2023 Category: Drugs & Pharmacology Authors: Tomasz P Lehmann Marta Golik Jolanta Olejnik Marianna Łukaszewska Dominika Markowska Martyna Dro żdżyńska Aleksander Kotecki Maciej G łowacki Pawe ł P Jagodziński Source Type: research
Tetrahydro- β-carboline derivatives as potent histone deacetylase 6 inhibitors with broad-spectrum antiproliferative activity
Eur J Med Chem. 2023 Aug 30;260:115776. doi: 10.1016/j.ejmech.2023.115776. Online ahead of print.ABSTRACTA series of tetrahydro-β-carboline (THβC)-based hydroxamic acids were rationally designed and synthesized as novel selective HDAC6 inhibitors (sHDAC6is) by the application of scaffold hopping strategy. Several THβC analogues were highly potent (IC50 < 5 nM) and selective against HDAC6 enzyme and exhibited good antiproliferative activity against human multiple myeloma (MM) cell. Molecular docking interpreted the structure activity relationship (SAR). Target engagement of HDAC6 was confirmed in RPMI-8226 cells using...
Source: European Journal of Medicinal Chemistry - September 3, 2023 Category: Chemistry Authors: Xin Chen Jiayun Wang Peng Zhao Baiyun Dang Ting Liang Raphael R Steimbach Aubry K Miller Jia Liu Xin Wang Tongtong Zhang Xiaofa Luan Jiadong Hu Jinming Gao Source Type: research
