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Initial experience with an electron FLASH research extension (FLEX) for the Clinac system
CONCLUSION: Our studies characterized the non-clinical Clinac-FLEX system as a viable solution to conduct FLASH research that could substantially increase access to ultra-high-dose-rate capabilities for scientists.PMID:37735808 | DOI:10.1002/acm2.14159
Source: Clinical Breast Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Kyuhak Oh Kyle J Gallagher Megan Hyun Diane Schott Sarah Wisnoskie Yu Lei Samuel Hendley Jeffrey Wong Shuo Wang Brendan Graff Christopher Jenkins Frank Rutar Md Ahmed Joshua McNeur Jeffrey Taylor Marty Schmidt Lasitha Senadheera Wendy Smith Donald Umstadt Source Type: research

CT-Guided Percutaneous Cryoablation for Lung Metastasis of Colorectal Cancer: A Case Series
CONCLUSION: Lung CA is a safe and well-tolerated treatment with a satisfactory local control rate for patients with lung metastases derived from mCRC.PMID:37735896 | DOI:10.1177/15330338231201508
Source: Technology in Cancer Research and Treatment - September 22, 2023 Category: Cancer & Oncology Authors: Fu-Ming Wang Rong Luo Jin-Ming Tian Hang Liu Ji-Jin Yang Source Type: research

Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Clinical Genitourinary Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research

Initial experience with an electron FLASH research extension (FLEX) for the Clinac system
CONCLUSION: Our studies characterized the non-clinical Clinac-FLEX system as a viable solution to conduct FLASH research that could substantially increase access to ultra-high-dose-rate capabilities for scientists.PMID:37735808 | DOI:10.1002/acm2.14159
Source: Clinical Genitourinary Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Kyuhak Oh Kyle J Gallagher Megan Hyun Diane Schott Sarah Wisnoskie Yu Lei Samuel Hendley Jeffrey Wong Shuo Wang Brendan Graff Christopher Jenkins Frank Rutar Md Ahmed Joshua McNeur Jeffrey Taylor Marty Schmidt Lasitha Senadheera Wendy Smith Donald Umstadt Source Type: research

Looking beyond the surface: Muir Torre syndrome
Arch Clin Cases. 2023 Sep 20;10(3):119-122. doi: 10.22551/2023.40.1003.10255. eCollection 2023.ABSTRACTMuir-Torre Syndrome (MTS) is associated with multiple visceral malignancies. Initial presentation may be a benign skin tumor mimicking a sebaceous cyst. This case report highlights the importance of early diagnosis, genetic testing, and multidisciplinary screening. A 67-year-old man was diagnosed with MTS following excision of a skin lesion (sebaceoma). He was declined both screening colonoscopy and genetic testing. Subsequently, advanced colon cancer was found following presentation with iron deficiency anemia, which ult...
Source: Clinical Colorectal Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Ekta Bagga David Innes Edmund Leung Source Type: research

Non-coding RNAs in cancer immunotherapy: Predictive biomarkers and targets
CONCLUSION: This review summarises important predictive ncRNA biomarkers that were reported in cancer patients treated with different immunotherapeutic modalities, including monoclonal antibodies, small molecule inhibitors, cancer vaccines and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilisation of immunomodulatory ncRNA biomarkers as predictive tools and therapeutic targets.PMID:37735815 | DOI:10.1002/ctm2.1425
Source: Clinical Colorectal Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Murad Alahdal Eyad Elkord Source Type: research

High-Throughput Screening of the Saccharomyces cerevisiae Genome for 2-Amino-3-Methylimidazo 4,5-f Quinoline Resistance Identifies Colon Cancer-Associated Genes
G3 (Bethesda). 2023 Sep 22:jkad219. doi: 10.1093/g3journal/jkad219. Online ahead of print.ABSTRACTHeterocyclic aromatic amines (HAAs) are potent carcinogenic agents found in charred meats and cigarette smoke. However, few eukaryotic resistance genes have been identified. We used Saccharomyces cerevisiae (budding yeast) to identify genes that confer resistance to 2-amino-3-methylimidazo[4,5-f] quinoline (IQ). CYP1A2 and NAT2 activate IQ to become a mutagenic nitrenium compound. Deletion libraries expressing human CYP1A2 and NAT2 or no human genes were exposed to either 400 or 800 µM IQ for five or ten generations. DNA barc...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Michael Dolan Nick St John Faizan Zaidi Francis Doyle Michael Fasullo Source Type: research

Oncologic outcomes of segmentectomy versus lobectomy for clinical T1c radiological pure-solid non-small cell lung cancer
CONCLUSIONS: In T1c radiological pure-solid non-small cell lung cancer, segmentectomy was significantly associated with worse survival and insufficient loco-regional cancer control. Lobectomy remains the standard surgical treatment; meanwhile, segmentectomy should be applied with great caution.PMID:37738593 | DOI:10.1093/icvts/ivad152
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Aritoshi Hattori Kazuya Takamochi Takeshi Matsunaga Mariko Fukui Kenji Suzuki Source Type: research

Paraneoplastic arthritis: a series of 92 cases
CONCLUSION: As a result, although PA is a rare condition, it can be confused with many rheumatological diseases. The most commonly involved joint is the knee joint, followed by the ankle and hand-wrist. Autoantibody negativity, high LDH level, and arthritis unresponsive to treatment constitute important clues for diagnosis.PMID:37738571 | DOI:10.1093/rheumatology/kead500
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: B ünyamin Kısacık Fatih Albayrak Mehmet Ali Balc ı Emrah Koc Source Type: research

Characterization of the Tumor Microenvironment of De Novo Oligometastatic Breast Cancer in a Nationwide Cohort
CONCLUSION: We identified tumor and ECM features in the primary tumor of patients with de novo OMBC that were associated with long-term survival. Our data should be validated in other patients with OMBC before they can be used in clinical practice.PMID:37738542 | DOI:10.1200/PO.22.00670
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Tessa G Steenbruggen Denise M Wolf Bram Thijssen Joyce Sanders Sten Cornelissen Roberto Salgado Lorenza Mittempergher Rajith Bhaskaran Annegien Broeks Esther H Lips Sabine Siesling Gabe S Sonke Hugo M Horlings Laura J van 't Veer Source Type: research

Projection of the number of new liver cancer cases in the world
Jpn J Clin Oncol. 2023 Sep 20:hyad126. doi: 10.1093/jjco/hyad126. Online ahead of print.NO ABSTRACTPMID:37738502 | DOI:10.1093/jjco/hyad126
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Kayo Nakata Sumiyo Okawa Source Type: research

A new method of estimating prevalence of childhood cancer survivors (POCCS): example of the 20-year prevalence in The Netherlands
CONCLUSIONS: Using the POCCS model and aggregated cancer data, our estimates of childhood cancer survivors limited-duration prevalence were consistent with those computed by a standard method requiring individual cancer records. The POCCS method provides relevant information for planning follow-up and care for childhood cancer survivors.PMID:37738448 | DOI:10.1093/ije/dyad124
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Andrea Gini Murielle Colombet Neimar de Paula Silva Otto Visser Danny Youlden Isabelle Soerjomataram Charles A Stiller Eva Steliarova-Foucher CRICCS Consortium Source Type: research

Definitive carbon ion re-irradiation with pencil beam scanning in the treatment of unresectable locally recurrent rectal cancer
In conclusion, definitive carbon ion re-irradiation with PBS provided superior oncologic results with tolerable toxicities and may be served as a curative treatment strategy in unresectable LRRC.PMID:37738440 | DOI:10.1093/jrr/rrad068
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Xin Cai Ping Li Jingfang Zhao Weiwei Wang Jingyi Cheng Guangyuan Zhang Sanjun Cai Zhen Zhang Guoliang Jiang Qing Zhang Zheng Wang Source Type: research

Pregnancy and progression of differentiated thyroid cancer: A propensity score-matched retrospective cohort study
CONCLUSIONS: Pregnancy seemed to be irrelevant to DTC progression-free survival before surgical treatment. Further prospective cohort studies are needed to translate this finding into clinical practice.PMID:37738427 | DOI:10.1210/clinem/dgad557
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Wu-Cai Xiao Xin Li Rui Shan Fang Mei Shi-Bing Song Jing Chen Bang-Kai Sun Chun-Hui Yuan Zheng Liu Source Type: research

Effects of Photobiomodulation Therapy on Lung Function and Inflammatory Factors in Patients with COVID-19 During Acute Stage
Conclusions: Application of photobiomodulation is recommended for treatment of respiratory problems in patients with COVID-19 to improve clinical signs and control inflammatory factors. Clinical Trial Registration: IRCT2017070934969N1.PMID:37738370 | DOI:10.1089/photob.2022.0157
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Fatemeh Ehsani Rasool Bagheri Mahbubeh Darban Maral Hemati Mohammad Bahrami Fatemeh Sharafieh Source Type: research