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Thymosin alpha 1 - Reimagine its broader applications in the immuno-oncology era
Int Immunopharmacol. 2023 Mar 3;117:109952. doi: 10.1016/j.intimp.2023.109952. Online ahead of print.ABSTRACTThymosin alpha 1 (Tα1) is a highly conserved 28 amino-acid peptide naturally occurring in the thymus and plays critical roles in T cell maturity and differentiation. Its synthetic form, thymalfasin, has been approved by various regulatory agencies in the treatment of hepatitis B viral infection and as an enhancer of vaccine response in immune-compromised populations. In China, it has also widely utilized in patients with cancer and severe infections, as well as the emergency use during (Severe Acute Respiratory Syn...
Source: International Immunopharmacology - March 5, 2023 Category: Allergy & Immunology Authors: Li Mao Source Type: research

Highlights into historical and current immune interventions for cancer
Int Immunopharmacol. 2023 Feb 27;117:109882. doi: 10.1016/j.intimp.2023.109882. Online ahead of print.ABSTRACTImmunotherapy is an additional pillar when combined with traditional standards of care such as chemotherapy, radiotherapy, and surgery for cancer patients. It has revolutionized cancer treatment and rejuvenated the field of tumor immunology. Several types of immunotherapies, including adoptive cellular therapy (ACT) and checkpoint inhibitors (CPIs), can induce durable clinical responses. However, their efficacies vary, and only subsets of cancer patients benefit from their use. In this review, we address three goal...
Source: International Immunopharmacology - February 27, 2023 Category: Allergy & Immunology Authors: Kathryn Cole Zaid Al-Kadhimi James E Talmadge Source Type: research

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Next-Generation Cancer Immunotherapy Targeting Glypican-3
This study was supported in part by the National Cancer Center Research and Development Fund (25-A-7 and 28-A-8); Health and Labor Science Research Grants for Clinical Research, Japan; and joint research funding from Takeda Pharmaceutical Co, Ltd.; Noile-Immune Biotech Inc.; Ono Pharmaceutical Co., Ltd.; BrightPath Biotherapeutics Co., Ltd.; and Sysmex Co., Ltd. This study was performed as part of a research program of the Project for Development of Innovative Research on Cancer Therapeutics (P-Direct), Ministry of Education, Culture, Sports, Science and Technology of Japan. Conflict of Interest Statement TN, TS, and TY ...
Source: Frontiers in Oncology - April 9, 2019 Category: Cancer & Oncology Source Type: research

Management of hepatocellular carcinoma
Conclusions In spite of significant advancement in HCC management, its incidence continues to rise. There remains an urgent need to continue refining understanding of HCC and develop strategies to increase utilization of the available preventive measures and curative treatment modalities for HCC.
Source: Journal of Cancer Research and Clinical Oncology - April 11, 2015 Category: Cancer & Oncology Source Type: research

Can Gingko and Turmeric Help Stop Ebola?
Summary There is no known pharmaceutical currently available that specifically treats Ebola disease. One treatment modality that should be considered is the use of herbal medicines, which have both centuries old anecdotal success as well as recent modern biochemical and formal research rationales for their use. Five areas of action that could be addressed by the herbal medicines as it relates to Ebola would be: VP24/immune system evasion GP protein/replicatio; herbal strategies effective against similar hemorrhagic disease beneficial modulation of patient immune and inflammatory response systems prophylactic use for heal...
Source: Inside Surgery - August 1, 2014 Category: Surgery Authors: Editor Tags: Infectious Disease ayurvedic baicalen cathepsin b dengue Ebola gingko herb Quercetin resveratrol rosemary sage st johns work turmeric Source Type: blogs