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Therapy: Thrombolytic Therapy
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Total 1360 results found since Jan 2013.
Thrombolysis ImPlementation in Stroke (TIPS): evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care
DiscussionTIPS will trial a comprehensive, multi-component and multidisciplinary collaborative approach to improving thrombolysis rates at multiple sites. The trial has the potential to identify methods for optimal care which can be implemented for stroke patients during the acute phase. Study findings will include barriers and solutions to effective thrombolysis implementation and trial outcomes will be published whether significant or not.Trial registration: Australian New Zealand Clinical Trials Registry: ACTRN12613000939796
Source: Implementation Science - March 25, 2014 Category: Health Management Authors: Christine PaulChristopher LeviCatherine D¿EsteMark ParsonsChristopher BladinRichard LindleyJohn AttiaFrans HenskensErin LalorMark LongworthSandy MiddletonAnnika RyanErin KerrRobert Sanson-Fisher Source Type: research
Baseline Body Temperature:Paradoxical Association with Severity and Non-Modification of Treatment Benefit in the NINDS TPA Stroke Trials (P3.101)
CONCLUSIONS: In hyperacute stroke patients, higher presenting temperatures are associated with less severe stroke deficits and final infarct volumes. Presenting temperature does not modify the benefit of tPA on good functional outcome at 3 months.Disclosure: Dr. Kim has nothing to disclose. Dr. Saver has received personal compensation for activities with the University of California, BrainsGate, CoAxia, ev3, Talecris, PhotoThera, Sygnis, and Stryker. Dr. Saver has received research support from the University of California, and the National Institutes of Health.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Kim, S. H., Saver, J. Tags: Cerebrovascular Disease and Interventional Neurology: t-PA Source Type: research
"Tele" Phone Medicine - Is Hearing Enough? (P7.121)
CONCLUSIONS: "Tele"-phone medicine used to initiate IV thrombolytic treatment in our population shows a higher rate than expected of hemorrhagic transformation and should be monitored closely. Telemedicine, health provider education, and organization of systems of care could help reduce complication rates in this patient population.Disclosure: Dr. Sugg has received personal compensation for activities with Genentech Inc. Dr. Jessica has nothing to disclose. Dr. Auchus has received personal compensation for activities with Novartis as a speaker. Dr. Auchus has received research support from Eisai Inc., and Elan Corporation.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Sugg, R., Jessica, M., Auchus, A. Tags: Cerebrovascular Disease and Interventional Neurology: Issues in Acute Stroke Treatment Source Type: research
Differences in the survival after an episode of stroke treated with thrombolytic therapy. Study Ebrictus.
CONCLUSIONS: After stroke episode treated with thrombolytic therapy, men have 12% higher risk of dying than women and don't be treated with secondary cardiovascular prevention rise 7.7 times the mortality risk.
PMID: 24953174 [PubMed - as supplied by publisher]
Source: Atencion Primaria - June 18, 2014 Category: Primary Care Authors: Clua-Espuny JL, Ripolles-Vicente R, Lopez-Pablo C, Panisello-Tafalla A, Lucas-Noll J, Calduch-Noll C, González-Henares MA, Queralt-Tomas ML Tags: Aten Primaria Source Type: research
Combined thrombolysis in posterior circulation stroke caused by bilateral vertebral artery dissection in squash player.
CONCLUSIONS: Vertebral artery dissection should be taken into consideration in differential diagnosis of posterior circulation stroke or TIA in young patients with a history of even as subtle precipitating events as forceful head movements. Combined thrombolytic therapy may provide safe and effective treatment of stroke-complicated cases. This case report shows that expanded diagnostic protocol for acute ischemic stroke, including computed tomography perfusion study and angiography of cervical and cranial vessels, assures rapid and correct diagnosis.
PMID: 25168332 [PubMed - indexed for MEDLINE]
Source: Neurologia i Neurochirurgia Polska - October 26, 2014 Category: Neurology Authors: Frankowska E, Brzozowski K, Staszewski J, Kolmaga N, Stępień A, Bogusławska-Walecka R Tags: Neurol Neurochir Pol Source Type: research
The rtPA increases MMP-9 activity in serum during ischaemic stroke.
CONCLUSIONS: Thrombolysis applied for IS treatment increases MMP-9 activity in serum, however, rtPA does not facilitate the conversion of pro-MMP-9 into the active form. Our results also suggest the involvement of MMP-3 to the biochemical processes occurring during acute phase of IS.
PMID: 25440008 [PubMed - in process]
Source: Neurologia i Neurochirurgia Polska - December 8, 2014 Category: Neurology Authors: Gołąb P, Boguszewska-Czubara A, Kiełbus M, Kurzepa J Tags: Neurol Neurochir Pol Source Type: research
Improvement in Rates of Thrombolytic Therapy in Acute Stroke by a Telestroke Program in Rural Northern Wisconsin (P1.011)
Conclusion: Following development of a Telestroke program in northern Wisconsin, rural stroke patients benefited from dramatic increases in access to neurological expertise and acute thrombolytic treatment. Patients and providers have embraced the program with plans to expand Telestroke to other remote access hospitals.Disclosure: Dr. Kartje has nothing to disclose. Dr. Klemm has nothing to disclose. Dr. Heil has nothing to disclose. Dr. Antoniotti has nothing to disclose. Dr. Martin has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kartje, R., Klemm, S., Heil, L., Antoniotti, N., Martin, T. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research
Balancing Autonomy and Beneficence in Acute Stroke Therapy: Neurologist Attitudes Toward Delaying Thrombolysis in Order to Obtain Informed Consent (P7.332)
CONCLUSIONS: Vascular neurologists indicate they emphasize beneficence over autonomy in deciding when to forego further attempts to reach consent providers to proceed with thrombolytic therapy under the doctrine of presumed consent. Their preference for rapid intervention is magnified when decisions are framed in person failure to benefit and neuron loss, compared with simple chronologic time.Disclosure: Dr. Kaplan has nothing to disclose. Dr. Cranston has nothing to disclose. Dr. Saver has received personal compensation for activities with the University of California, BrainsGate, CoAxia, eV3, Talecris Biotherapeutics Inc...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kaplan, B., Cranston, J., Saver, J. Tags: Practice, Policy, and Ethics Source Type: research
A Novel Method for Measuring Oxidative Stress in Patients with Stroke Symptoms (S52.005)
CONCLUSIONS: These results demonstrate the ability of ORP to identify oxidative stress and amount of antioxidant reserves in a stroke population. We propose ORP monitoring as a potentially useful tool in evaluation of acute stroke patients.Disclosure: Dr. Wagner has received personal compensation for activities with Genentech, Inc. Dr. Salottolo has nothing to disclose. Dr. Fanale has received personal compensation for activities with Genentech, Inc. as a speaker. Dr. Whaley has nothing to disclose. Dr. McCarthy has nothing to disclose. Luoxis Diagnostics, Inc,
Source: Neurology - April 8, 2015 Category: Neurology Authors: Wagner, J., Salottolo, K., Fanale, C., Whaley, M., McCarthy, K., BarOr, D. Tags: General Neurology: Neural Networks and Neuromodulation Source Type: research
Assessment of acute stroke cerebral CT examinations by anaesthesiologists
ConclusionsThis study suggests that anaesthesiologists who are experienced in pre‐hospital care may be quickly trained to assess cerebral CT examinations in acute stroke patients with regard to radiological contraindications for thrombolytic therapy.
Source: Acta Anaesthesiologica Scandinavica - May 1, 2015 Category: Anesthesiology Authors: M. R. Hov, T. Nome, E. Zakariassen, D. Russell, J. Røislien, H. M. Lossius, C. G. Lund Tags: Original Article Source Type: research
Stroke of a cardiac myxoma origin
Conclusion: Cardiac myxoma stroke is rare. Often does it affect young females. For an improved diagnostic accuracy, magnetic resonance imaging of the brain and echocardiography are imperative for young stroke patients in identifying the cerebral infarct and determining the stroke of a cardiac origin. Immediate thrombolytic therapy may completely resolve the cerebral stroke and improve the neurologic function of the patients. An early surgical resection of cardiac myxoma is recommended in patients with not large territory cerebral infarct. Resumo Objetivo: As características clínicas do acidente vascular cerebral causado ...
Source: Revista Brasileira de Cirurgia Cardiovascular - June 19, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research
Functional Outcome of Hemorrhagic Transformation after Thrombolysis for Ischemic Stroke: A Prospective Study
Conclusion: HT after thrombolysis is very frequent on SWI, but the initial stroke severity is an important predictor to assess the role of HT for patient outcome.Cerebrovasc Dis Extra 2015;5:103-106
Source: Cerebrovascular Diseases Extra - October 9, 2015 Category: Neurology Source Type: research
A clinical decision support tool to screen health records for contraindications to stroke thrombolysis–a pilot study
Conclusions:
By screening health records for relevant contraindications, the use of a CDS tool may reduce the time needed to review medical records and reduce the number of missed contraindications for stroke thrombolysis.
Source: BMC Medical Informatics and Decision Making - December 14, 2015 Category: Information Technology Authors: Mu-Chien SunJo-Ann Chan Source Type: research
Risk of pneumonia associated with zero‐degree head positioning in acute ischemic stroke patients treated with intravenous tissue plasminogen activator
ConclusionsZero‐degree head of bed positioning in the first 24 h following an acute ischemic stroke treated with IV‐tPA was associated with acceptable rates of pneumonia. Rates for pneumonia may be further reduced by eliminating use of a 0° protocol in intubated/mechanically ventilated patients.
A zero‐degree head of bed position is recommended to increase cerebral perfusion in nonhypoxic acute ischemic stroke patients able to tolerate lying flat. However, this is not uniformly applied in clinical practice, most likely due to concerns of aspiration pneumonia. In our retrospective descriptive study, zero‐degree p...
Source: Brain and Behavior - December 1, 2015 Category: Neurology Authors: Paola Palazzo, Amy Brooks, David James, Randy Moore, Andrei V. Alexandrov, Anne W. Alexandrov Tags: Original Research Source Type: research
Fifty years of stroke researches in India
Tapas Kumar Banerjee, Shyamal Kumar DasAnnals of Indian Academy of Neurology 2016 19(1):1-8Currently, the stroke incidence in India is much higher than Western industrialized countries. Large vessel intracranial atherosclerosis is the commonest cause of ischemic stroke in India. The common risk factors, that is, hypertension, diabetes, smoking, and dyslipidemia are quite prevalent and inadequately controlled; mainly because of poor public awareness and inadequate infrastructure. Only a small number of ischemic stroke cases are able to have the benefit of thrombolytic therapy. Benefits from stem cell therapy in established ...
Source: Annals of Indian Academy of Neurology - February 2, 2016 Category: Neurology Authors: Tapas Kumar BanerjeeShyamal Kumar Das Source Type: research
