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Specialty: Stem Cells
Therapy: Stem Cell Therapy
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Total 184 results found since Jan 2013.
Clinical Translation of Cell Therapies in Stroke (CT2S) Checklist —a pragmatic tool to accelerate development of cell therapy products
Cell therapies present an exciting potential but there is a long history of expensive translational failures in stroke research. Researchers engaged in cell therapy research would benefit from a practical fram...
Source: Stem Cell Research and Therapy - January 29, 2021 Category: Stem Cells Authors: Anjali Nagpal, Austin G. Milton, Simon A. Koblar and M. Anne Hamilton-Bruce Tags: Method Source Type: research
The role of small extracellular vesicles in cerebral and myocardial ischemia —Molecular signals, treatment targets, and future clinical translation
Extracellular vesicle (EV) ‐based therapeutic strategies. (a) EVs can be modified by adding peptides in order to increase the targeting ability or stability. (b) Stem cell‐derived EVs can be used directly because of their low immunogenicity and cell affinity. (c) Bioengineering of stem cells that secret enriched target pr oteins or miRNAs within EVs can increase their therapeutic effects. AbstractThe heart and the brain mutually interact with each other, forming a functional axis that is disturbed under conditions of ischemia. Stem cell ‐derived extracellular vesicles (EVs) show great potential for the treatment of i...
Source: Stem Cells - January 12, 2021 Category: Stem Cells Authors: Xuan Zheng,
Dirk M. Hermann,
Mathias B ähr,
Thorsten R. Doeppner Tags: Translational and Clinical Research Source Type: research
Bone marrow ‐derived myeloid progenitors in the leptomeninges of adult mice
This study identified a heterogeneous population of myeloid progenitors in the leptomeninges of adult mice, which gave rise to all major myelo ‐erythroid lineages in clonogenic assays. Lineage tracing and bone marrow transplantation showed that the progenitors were derived from adult hematopoietic stem cells and most likely continuously replaced via cell trafficking. Their numbers were diminished in the context of neuroinflammation. AbstractAlthough the bone marrow contains most hematopoietic activity during adulthood, hematopoietic stem and progenitor cells can be recovered from various extramedullary sites. Cells with ...
Source: Stem Cells - December 11, 2020 Category: Stem Cells Authors: Tobias Koeniger,
Luisa Bell,
Anika Mifka,
Michael Enders,
Valentin Hautmann,
Subba Rao Mekala,
Philipp Kirchner,
Arif B. Ekici,
Christian Schulz,
Philipp W örsdörfer,
Stine Mencl,
Christoph Kleinschnitz,
Süleyman Ergün,
Stefanie Kuerten Tags: Tissue ‐Specific Stem Cells Source Type: research
Protective effects of mesenchymal stem cells on ischemic brain injury: therapeutic perspectives of regenerative medicine
AbstractCerebral ischemic injury as the main manifestation of stroke can occur in stroke patients (70 –80%). Nowadays, the main therapeutic strategy used for ischemic brain injury treatment aims to achieve reperfusion, neuroprotection, and neurorecovery. Also, angiogenesis as a therapeutic approach maybe represents a promising tool to enhance the prognosis of cerebral ischemic stroke. Unfortunatel y, although many therapeutic approaches as a life-saving gateway for cerebral ischemic injuries like pharmacotherapy and surgical treatments are widely used, they all fail to restore or regenerate damaged neurons in the brain. ...
Source: Cell and Tissue Banking - November 24, 2020 Category: Stem Cells Source Type: research
Momordica charantia polysaccharides modulate the differentiation of neural stem cells via SIRT1/ Β-catenin axis in cerebral ischemia/reperfusion
Stroke is the leading cause of long-term motor disability and cognitive impairment. Recently, neurogenesis has become an attractive strategy for the chronic recovery of stroke. It is important to understand th...
Source: Stem Cell Research and Therapy - November 16, 2020 Category: Stem Cells Authors: Zhaoli Hu, Fengying Li, Xiaoling Zhou, Feng Zhang, Linyan Huang, Bing Gu, Jiangang Shen and Suhua Qi Tags: Research Source Type: research
miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway
We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in hemorrhagic stroke have not been investigated. ...
Source: Stem Cell Research and Therapy - October 26, 2020 Category: Stem Cells Authors: Yuchen Li, Jinju Wang, Shuzhen Chen, Pei Wu, Shancai Xu, Chunlei Wang, Huaizhang Shi and Ji Bihl Tags: Research Source Type: research
Establishment of variant free-iPSC (UOMi003-A) line from patient with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes
Publication date: Available online 3 August 2020Source: Stem Cell ResearchAuthor(s): Glen Lester Sequiera, Cheryl Rockman-Greenberg, Sanjiv Dhingra
Source: Stem Cell Research - August 5, 2020 Category: Stem Cells Source Type: research
Ischemia-Induced Multipotent Stem Cells Isolated from Stroke Patients Exhibit Higher Neurogenic Differentiation Potential than Bone Marrow-Derived Mesenchymal Stem Cells
Stem Cells and Development, Ahead of Print.
Source: Stem Cells and Development - July 1, 2020 Category: Stem Cells Authors: Saujanya Rajbhandari Mikiya Beppu Toshinori Takagi Akiko Nakano-Doi Nami Nakagomi Tomohiro Matsuyama Takayuki Nakagomi Shinichi Yoshimura Source Type: research
Transplantation of Stem Cells as a Potential Therapeutic Strategy in Neurodegenerative Disorders.
Abstract
Stem cells are considered to have significant capacity to differentiate into various cell types in humans or animals. Unlike specialized cells, these cells can proliferate several times to produce millions of cells. Nowadays, pluripotent stem cells are important candidates to provide a renewable source for replacement of cells in tissues of interest. The damage to neurons and glial cells in the brain or spinal cord is present in neurological disorders such as Amyotrophic lateral sclerosis, stroke, Parkinson's disease, multiple sclerosis, Alzheimer's disease, Huntington's disease, spinal cord injury, lysos...
Source: Current Stem Cell Research and Therapy - June 27, 2020 Category: Stem Cells Authors: Ebrahimi T, Abasi M, Seifar F, Eyvazi S, Hejazi MS, Tarhriz V, Montazersaheb S Tags: Curr Stem Cell Res Ther Source Type: research
Stem cell-based therapies for ischemic stroke: a systematic review and meta-analysis of clinical trials
Recently, extensive researches about stem cell-based therapies for ischemic stroke have been published; our review evaluated the efficacy and safety of stem cell-based therapies for ischemic stroke. Our review...
Source: Stem Cell Research and Therapy - June 26, 2020 Category: Stem Cells Authors: Zhonghao Li, Xiaoke Dong, Min Tian, Chongchong Liu, Kaiyue Wang, Lili Li, Zunjing Liu and Jinmin Liu Tags: Review Source Type: research
Intra-carotid arterial transfusion of circulatory-derived autologous endothelial progenitor cells in rodent after ischemic stroke —evaluating the impact of therapeutic time points on prognostic outcomes
This study tested the optimal time point for left intra-carotid arterial (LICA) administration of circulatory-derived autologous endothelial progenitor cells (EPCs) for improving the outcome in rat after acute...
Source: Stem Cell Research and Therapy - June 5, 2020 Category: Stem Cells Authors: Kun-Chen Lin, Han-Tan Chai, Kuan-Hung Chen, Pei-Hsun Sung, John Y. Chiang, Pei-Lin Shao, Chi-Ruei Huang, Yi-Chen Li, Sheung-Fat Ko and Hon-Kan Yip Tags: Research Source Type: research
