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Specialty: Cytology
Therapy: Stem Cell Therapy
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Total 198 results found since Jan 2013.
Stem Cell Implants: Emerging Innovation for Stroke Recovery
J Neuro Oncol Res. 2023;3(1):3102. Epub 2023 Apr 30.ABSTRACTStroke is a debilitating neurovascular injury that those effects hundreds of thousands of Americans each year. Despite the high prevalence, disease morbidity and mortality, options for stroke intervention and rehabilitation are still limited. Stem cells have shown promise in stroke treatment due to their ability to self-renew and differentiate into different cell types. The primary sources of stem cells used today are bone marrow and fetal brain tissue, with mesenchymal stem cells, bone marrow stem cells and neural stem cells being particularly well-studied. By se...
Source: Cell Research - May 25, 2023 Category: Cytology Authors: Reid Colliander Kaitlyn Alleman Michael Diaz Med Jimenez Patrick King Pranav Mirpuri Christopher Cutler Brandon Lucke-Wold Source Type: research
Correction: Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke
Stem Cell Res Ther. 2023 May 8;14(1):123. doi: 10.1186/s13287-023-03362-z.NO ABSTRACTPMID:37158966 | DOI:10.1186/s13287-023-03362-z
Source: Cell Research - May 9, 2023 Category: Cytology Authors: Satoru Yabuno Takao Yasuhara Takayuki Nagase Satoshi Kawauchi Chiaki Sugahara Yosuke Okazaki Kakeru Hosomoto Susumu Sasada Tatsuya Sasaki Naoki Tajiri Cesar V Borlongan Isao Date Source Type: research
Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the Therapeutic of ischemic stroke
Curr Stem Cell Res Ther. 2023 May 5. doi: 10.2174/1574888X18666230505103407. Online ahead of print.ABSTRACTIschemic stroke is the leading cause of death and disability worldwide, with increasing incidence and mortality, imposing a significant social and economic burden on patients and their families. However, cerebral vascular occlusion leads to acute loss of neurons and destruction of synaptic structures. The limited treatment options cannot adequately address intra-neuronal mitochondrial dysfunction due to stroke. Therefore, stem cell-derived mitochondria transplantation plays an important role in neuronal protection and...
Source: Cell Research - May 8, 2023 Category: Cytology Authors: Yidong Liao Jiang Ming Wenxue Song Guangtang Chen Junshuan Cui Longcai He Zili Wang Xudong Wang Mingsong Xiong Hua Yang Kaya Xu Source Type: research
Stem Cell Therapy for Ischemic Brain Injury: Early Intranasal Delivery after Cardiac Arrest
Transl Stroke Res. 2023 Apr 4. doi: 10.1007/s12975-023-01150-8. Online ahead of print.ABSTRACTGlobal ischemic brain injury is the leading cause of mortality and long-term disability in patients resuscitated from cardiac arrest. Hypothermia and neuroprotective agents are two strategies partially improve neurological outcomes following resuscitation. However, the therapeutic effects of these treatments are inconsistently reported. Stem cell therapy has emerged as a promising protective strategy due to its potential for proliferation and differentiation into functional neural cells. This editorial reviews the current status o...
Source: Cell Research - April 4, 2023 Category: Cytology Authors: Xiao Liu Xiaofeng Jia Source Type: research
Therapeutic potential of stem cell extracellular vesicles for ischemic stroke in preclinical rodent models: a meta-analysis
CONCLUSION: The present meta-analysis confirmed that SC-EV therapy could improve neuron function and reduce infarct volume in a preclinical rodent ischemic stroke model, providing helpful clues for human clinical trials on SC-EVs.PMID:37013588 | DOI:10.1186/s13287-023-03270-2
Source: Cell Research - April 4, 2023 Category: Cytology Authors: Jing Zhao Huiyin Deng Chengfeng Xun Chunli Chen Zhiping Hu Lite Ge Zheng Jiang Source Type: research
A Novel Rat Model of Embolic Cerebral Ischemia Using a Cell-Implantable Radiopaque Hydrogel Microfiber
We present a novel rat model of focal infarct restricted to the middle cerebral artery territory using a radiopaque hydrogel microfiber positioned under fluoroscopic guidance. By comparing the use of stem cell-containing versus non-containing fibers in this stroke model, it would be possible to determine the efficacy of "pure" cell transplantation in treating stroke.PMID:36867349 | DOI:10.1007/s12975-023-01144-6
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Teppei Komatsu Hiroki Ohta Naoki Takakura Junichi Hata Tomomichi Kitagawa Yuta Kurashina Hiroaki Onoe Hirotaka James Okano Yasuyuki Iguchi Source Type: research
Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: expression changes of NMDA receptor subunits and NT-3
This study was designed to discover the effect of MSCs injection in the nucleus accumbens (NAc) on the reinstatement of behavior in morphine-induced conditioned place preference (CPP) in male rats. The CPP was induced via intra-peritoneal (i.p.) morphine injection (5mg/kg) for three consecutive days. After being tested for CPP induction, animals received MSCs or culture medium (DMEM F-12) in their NAc using stereotaxic surgery. Following extinction, a priming dose of morphine (2mg/kg) was administered to induce reinstatement. Expression of GluN1, GluN2A, and GluN2B subunits of the NMDA receptor and the NT-3 gene in the NAc...
Source: Cell Research - February 28, 2023 Category: Cytology Authors: Parviz Dousti Kataj Nasim Vousooghi Mahmoud Reza Hadjighassem Maryam Farahmandfar Somayeh Ebrahimi-Barough Source Type: research
Stem Cell Therapies for Intracerebral Hemorrhage: Review of Preclinical and Clinical Studies
Cell Transplant. 2023 Jan-Dec;32:9636897231158153. doi: 10.1177/09636897231158153.ABSTRACTDespite recent developments in the treatments for ischemic stroke, such as tissue plasminogen activator (t-PA) and thrombectomy, effective therapies for intracerebral hemorrhage (ICH) remain scarce. Stem cell therapies have attracted considerable attention owing to their potential neuro-regenerative ability; preclinical and clinical studies have been conducted to explore strategies for achieving functional recovery following ICH. In this review, we summarize the findings of preclinical studies on stem cell therapies of ICH, with a foc...
Source: Cell Transplantation - February 24, 2023 Category: Cytology Authors: Soichiro Takamiya Masahito Kawabori Miki Fujimura Source Type: research
Hepatocyte growth factor-modified hair follicle stem cells ameliorate cerebral ischemia/reperfusion injury in rats
CONCLUSION: Our results indicate for the first time that HGF modified HFSCs can reduce I/R injury and promote the neurological recovery by inhibiting inflammatory response, protecting blood-brain barrier and promoting angiogenesis.PMID:36782269 | DOI:10.1186/s13287-023-03251-5
Source: Cell Research - February 14, 2023 Category: Cytology Authors: Hao Tang Xuemei Zhang Xiaojun Hao Haitong Dou Chendan Zou Yinglian Zhou Bing Li Hui Yue Duo Wang Yifei Wang Chunxiao Yang Jin Fu Source Type: research
Exosomal ZEB1 Derived from Neural Stem Cells Reduces Inflammation Injury in OGD/R-Treated Microglia via the GPR30-TLR4-NF- κB Axis
Neurochem Res. 2023 Jan 30. doi: 10.1007/s11064-023-03866-3. Online ahead of print.ABSTRACTIschemic stroke (IS) is the most common type of stroke and the second leading cause of death overall. Neural stem cells play protective roles in IS, but the underlying mechanism remains to be determined. Neural stem cells (NSC) were obtained from the fetal brain tissue of C57BL/6J mice. NSC-derived exosomes (NSC-Exos) were identified in the conditioned medium. Internalization of NSC-Exos was analyzed by fluorescence microscopy. In vitro microglia ischemic stroke injury model was induced using oxygen glucose deprivation/re-oxygenation...
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Jun Peng Zhengtao Yu Rongjun Xiao Xiqi Hu Ying Xia Source Type: research
Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke
CONCLUSIONS: This study suggests that combination therapy of intracerebral transplantation SB623 cells and voluntary exercise with RW achieves robust neurological recovery and synergistically promotes endogenous neurogenesis and angiogenesis after cerebral ischemia, possibly through a mechanism involving the up-regulation of BDNF and VEGF.PMID:36691091 | DOI:10.1186/s13287-023-03236-4
Source: Cell Research - January 23, 2023 Category: Cytology Authors: Satoru Yabuno Takao Yasuhara Takayuki Nagase Satoshi Kawauchi Chiaki Sugahara Yosuke Okazaki Kakeru Hosomoto Susumu Sasada Tatsuya Sasaki Naoki Tajiri Cesar V Borlongan Isao Date Source Type: research
Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling
Cell Stress Chaperones. 2023 Jan 9. doi: 10.1007/s12192-022-01319-4. Online ahead of print.ABSTRACTApoptosis mediated by endoplasmic reticulum (ER) stress plays a crucial role in several neurovascular disorders, including ischemia/reperfusion injury (I/R injury). Previous in vitro and in vivo studies have suggested that following I/R injury, ER stress is vital for mediating CCAT-enhancer-binding protein homologous protein (CHOP) and caspase-12-dependent apoptosis. However, its modulation in the presence of stem cells and the underlying mechanism of cytoprotection remains elusive. In vivo studies from our lab have reported ...
Source: Cell Stress and Chaperones - January 9, 2023 Category: Cytology Authors: Harpreet Kaur Deepaneeta Sarmah Aishika Datta Anupom Borah Dileep R Yavagal Pallab Bhattacharya Source Type: research
Exosome therapies improve outcome in rodents with ischemic stroke; Meta-analysis
This study systematically evaluated the efficacy of exosome therapy in ischemic stroke based on preclinical studies in rodent models.METHODS: We reviewed existing literature on exosome therapy in rodent stroke models from various databases, and reviewed the interventional measures, and outcome measures systematically, with changes in the infarct volume and functional scores as outcome parameters. Seventeen homogeneous studies were found qualitatively acceptable for meta-analysis. The study used software RevMan 5.3 to conduct the meta-analysis (PROSPERO Register Number: CRD42022314138) RESULTS: Compared to placebo, exosomes...
Source: Cell Research - January 2, 2023 Category: Cytology Authors: Simy Grace Cherian Sunil K Narayan Murugesan Arumugam Source Type: research
