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Specialty: Cytology
Therapy: Stem Cell Therapy
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Total 198 results found since Jan 2013.
Prognostic Signature for Human Umbilical Cord Mesenchymal Stem Cell Treatment of Ischemic Cerebral Infarction by Integrated Bioinformatic Analysis
Biomed Res Int. 2022 Dec 13;2022:9973232. doi: 10.1155/2022/9973232. eCollection 2022.ABSTRACTIn recent studies, stem cell-based therapy is a potential new approach in the treatment of stroke. The mechanism of human umbilical cord mesenchymal stem cell (hUMSC) transplantation as one of the new approaches in the treatment of ischemic stroke is still unclear. The aim of this study was to determine the traits of immune responses during stroke progression after treatment with human umbilical cord blood MSCs by bioinformatics, to predict potential prognostic biomarkers that could lead to sex differences, and to reveal potential...
Source: Cell Research - December 23, 2022 Category: Cytology Authors: Zhifeng Wen Fangxi Liu Xinyu Lin Shanshan Zhong Xiuchun Zhang Zhike Zhou Jukka Jolkkonen Chang Liu Chuansheng Zhao Source Type: research
Overexpression of vascular endothelial growth factor enhances the neuroprotective effects of bone marrow mesenchymal stem cell transplantation in ischemic stroke
Neural Regen Res. 2023 Jun;18(6):1286-1292. doi: 10.4103/1673-5374.358609.ABSTRACTAlthough bone marrow mesenchymal stem cells (BMSCs) might have therapeutic potency in ischemic stroke, the benefits are limited. The current study investigated the effects of BMSCs engineered to overexpress vascular endothelial growth factor (VEGF) on behavioral defects in a rat model of transient cerebral ischemia, which was induced by middle cerebral artery occlusion. VEGF-BMSCs or control grafts were injected into the left striatum of the infarcted hemisphere 24 hours after stroke. We found that compared with the stroke-only group and the ...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Cui Liu Zhi-Xiang Yang Si-Qi Zhou Ding Ding Yu-Ting Hu Hong-Ning Yang Dong Han Shu-Qun Hu Xue-Mei Zong Source Type: research
Combination of indirect revascularization and endothelial progenitor cell transplantation improved cerebral perfusion and ameliorated tauopathy in a rat model of bilateral ICA ligation
CONCLUSION: The results of this study suggested that indirect revascularization ameliorated the cerebral ischemic changes. EPCs played a key role in augmenting the effect of indirect revascularization in the treatment of chronic cerebral ischemia.PMID:36371197 | DOI:10.1186/s13287-022-03196-1
Source: Cell Research - November 12, 2022 Category: Cytology Authors: Kuo-Chuan Wang Ling-Yu Yang Jing-Er Lee Vicent Wu Te-Fu Chen Sung-Tsang Hsieh Meng-Fai Kuo Source Type: research
Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process
Eur J Med Res. 2022 Nov 4;27(1):232. doi: 10.1186/s40001-022-00833-6.ABSTRACTAngiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorder...
Source: Cell Research - November 5, 2022 Category: Cytology Authors: Ahmad Hoseinzadeh Hamed Ghoddusi Johari Mohammad Hossein Anbardar Lobat Tayebi Ehsan Vafa Milad Abbasi Ahmad Vaez Ali Golchin Ali Mohammad Amani Ali Jangjou Source Type: research
MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1
CONCLUSION: Collectively, exosomal miR-145-derived from MSCs was able to attenuate cerebral I/R injury through downregulation of FOXO1. These studies may serve as a potential approach for treating of cerebral I/R injury.PMID:36206599 | DOI:10.1016/j.bbrc.2022.09.089
Source: Cell Research - October 7, 2022 Category: Cytology Authors: Hai Zhou Jing Zhou Hongwei Teng Hua Yang Jinsong Qiu Xiangdong Li Source Type: research
Dental Pulp Stem Cell-Derived Conditioned Medium Alleviates Subarachnoid Hemorrhage-Induced Microcirculation Impairment by Promoting M2 Microglia Polarization and Reducing Astrocyte Swelling
This study aimed to investigate whether dental pulp stem cell conditioned medium (DPSC-CM) ameliorates SAH-induced microcirculation impairment and the underlying mechanisms. SAH was induced via intrathecal injection of fresh autologous blood in Wistar male adult rat. DPSC-CM or DPSC-CM + insulin growth factor-1 (IGF-1) antibody was randomly administered by intrathecal route 5 min after SAH induction. To evaluate the underlying mechanisms of DPSC-CM in the treatment of SAH, primary rat astrocyte and microglia co-cultures were challenged with hemolysate or SAH-patient CSF in the presence or absence of DPSC-CM. The results sh...
Source: Cell Research - October 1, 2022 Category: Cytology Authors: Ling-Yu Yang Yong-Ren Chen Jing-Er Lee Kuo-Wei Chen Hui-Tzung Luh Yi-Tzu Chen Kuo-Chuan Wang Sung-Tsang Hsieh Source Type: research
Substance P Reduces Infarct Size and Mortality After Ischemic Stroke, Possibly Through the M2 Polarization of Microglia/Macrophages and Neuroprotection in the Ischemic Rat Brain
Cell Mol Neurobiol. 2022 Sep 16. doi: 10.1007/s10571-022-01284-7. Online ahead of print.ABSTRACTSubstance-P (SP) is an 11 amino acid neuropeptide that is known to stimulate the peripheral mobilization of bone marrow mesenchymal stem cells and M2 polarization in monocytes/macrophages in a variety of acute and chronic tissue injuries. To examine the role of SP in protection and recovery from acute ischemic brain injury, experimental ischemic stroke was induced by transient middle cerebral artery occlusion (tMCAo) in rats for 1 h with subsequent reperfusion. Two injections of SP, immediately and one day post-tMCAo, resulted i...
Source: Cellular and Molecular Neurobiology - September 16, 2022 Category: Cytology Authors: Woosung Ahn Guangfan Chi Sumin Kim Youngsook Son Mingzi Zhang Source Type: research
Human Oral Mucosa Stem Cells Increase Survival of Neurons Affected by In Vitro Anoxia and Improve Recovery of Mice Affected by Stroke Through Time-limited Secretion of miR-514A-3p
Cell Mol Neurobiol. 2022 Sep 9. doi: 10.1007/s10571-022-01276-7. Online ahead of print.ABSTRACTThe success rate of regenerative medicine largely depends on the type of stem cells applied in such procedures. Consequently, to achieve the needed level for clinical standardization, we need to investigate the viability of accessible sources with sufficient quantity of cells. Since the oral region partly originates from the neural crest, which naturally develops in niche with decreased levels of oxygen, the main goal of this work was to test if human oral mucosa stem cells (hOMSC) might be used to treat neurons damaged by anoxia...
Source: Cellular and Molecular Neurobiology - September 9, 2022 Category: Cytology Authors: Paula Stan čin Min Suk Song Ivan Alajbeg Dinko Mitre čić Source Type: research
Endogenous Neural Stem Cell-induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives
Transl Stroke Res. 2022 Sep 3. doi: 10.1007/s12975-022-01078-5. Online ahead of print.ABSTRACTIschemic stroke is a very common cerebrovascular accident that occurred in adults and causes higher risk of neural deficits. After ischemic stroke, patients are often left with severe neurological deficits. Therapeutic strategies for ischemic stroke might mitigate neuronal loss due to delayed neural cell death in the penumbra or seek to replace dead neural cells in the ischemic core. Currently, stem cell therapy is the most promising approach for inducing neurogenesis for neural repair after ischemic stroke. Stem cell treatments i...
Source: Cell Research - September 3, 2022 Category: Cytology Authors: Hailiang Tang Yao Li Weijun Tang Jianhong Zhu Graham C Parker John H Zhang Source Type: research
Muse cells: ushering in a new era of stem cell-based therapy for stroke
Stem Cell Res Ther. 2022 Aug 19;13(1):421. doi: 10.1186/s13287-022-03126-1.ABSTRACTStem cell-based regenerative therapies have recently become promising and advanced for treating stroke. Mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) have received the most attention for treating stroke because of the outstanding paracrine function of MSCs and the three-germ-layer differentiation ability of iPSCs. However, the unsatisfactory homing ability, differentiation, integration, and survival time in vivo limit the effectiveness of MSCs in regenerative medicine. The inherent tumorigenic property of iPSCs ren...
Source: Cell Research - August 19, 2022 Category: Cytology Authors: Han Li Jinghui Wei Xuejia Liu Ping Zhang Juntang Lin Source Type: research
