• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Positive Phase III results for Roche ’s OCREVUS (ocrelizumab) twice a year, 10-minute subcutaneous injection in patients with multiple sclerosis
Phase III OCARINA II trial met primary and secondary endpointsOCREVUS twice a year, 10-minute injection has the potential to further improve the treatment experience and expand OCREVUS usage in MS centres with IV capacity limitations or without IV infrastructureOCREVUS remains the first and only therapy approved for both RMS and PPMS, and more than 300,000 people have been treated globallyBasel, 13 July 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that the Phase III OCARINA II trial evaluating OCREVUS ® (ocrelizumab) as a twice a year 10-minute subcutaneous injection met its primary and secondary endpoints in...
Source: Roche Media News - July 13, 2023 Category: Pharmaceuticals Source Type: news

GABAergic neurons differentiated from BDNF- and Dlx2-modified neural stem cells restore disrupted neural circuits in brainstem stroke
CONCLUSIONS: These findings demonstrated that BDNF- and Dlx2-modified NSCs differentiated into GABAergic neurons, integrated into and reconstituted the host neural networks, and alleviated the ischemic injury. It thus provided a potential therapeutic strategy for brainstem stroke.PMID:37365654 | DOI:10.1186/s13287-023-03378-5
Source: Cell Research - June 26, 2023 Category: Cytology Authors: Xiangyue Tang Li Wu Juehua Zhu Mindong Xu Shaojun Li Guanfeng Zeng Shuanggen Zhu Yongjun Jiang Source Type: research

A Novel Rat Model of Embolic Cerebral Ischemia Using a Cell-Implantable Radiopaque Hydrogel Microfiber
We present a novel rat model of focal infarct restricted to the middle cerebral artery territory using a radiopaque hydrogel microfiber positioned under fluoroscopic guidance. By comparing the use of stem cell-containing versus non-containing fibers in this stroke model, it would be possible to determine the efficacy of "pure" cell transplantation in treating stroke.PMID:36867349 | DOI:10.1007/s12975-023-01144-6
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Teppei Komatsu Hiroki Ohta Naoki Takakura Junichi Hata Tomomichi Kitagawa Yuta Kurashina Hiroaki Onoe Hirotaka James Okano Yasuyuki Iguchi Source Type: research

Vitality ‐Enhanced Dual‐Modal Tracking System Reveals the Dynamic Fate of Mesenchymal Stem Cells for Stroke Therapy
Intravenously transplanted bioengineered mesenchymal stem cell (MSC) achieve high vitality in a harsh environment. With the help of an extracellular antioxidative layer, vitality-enhanced MSCs remodel the microenvironment and improve the therapeutic outcomes. A magnetic resonance imaging and near-infrared fluorescence dual-mode tracking system reveals that MSCs prefer livable niches to maintain high vitality for therapeutic purposes and behave intelligently during the development of pathology and recovery. AbstractMesenchymal stem cell (MSC) therapy via intravenous transplantation exhibits great potential for brain tissue ...
Source: Small - October 1, 2022 Category: Nanotechnology Authors: Jianpei Xu, Yuwen Zhang, Yipu Liu, Yang You, Fengan Li, Yu Chen, Laozhi Xie, Shiqiang Tong, Songlei Zhou, Kaifan Liang, Yukun Huang, Gan Jiang, Qingxiang Song, Ni Mei, Fenfen Ma, Xiaoling Gao, He Wang, Jun Chen Tags: Research Article Source Type: research

Infarct-preconditioning exosomes of umbilical cord mesenchymal stem cells promoted vascular remodeling and neurological recovery after stroke in rats
CONCLUSIONS: Our results demonstrated that infarct-preconditioned exosomes promoted neurological recovery after stroke by enhancing vascular endothelial remodeling, suggested that infarct-preconditioned exosomes could be a novel way to alleviate brain damage following a stroke.PMID:35902882 | DOI:10.1186/s13287-022-03083-9
Source: Cell Research - July 28, 2022 Category: Cytology Authors: Yi-Chao Ye Zhe-Han Chang Peng Wang You-Wei Wang Jun Liang Chong Chen Jing-Jing Wang Hong-Tao Sun Yi Wang Xiao-Hong Li Source Type: research

Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke
Transl Stroke Res. 2022 Jul 28. doi: 10.1007/s12975-022-01057-w. Online ahead of print.ABSTRACTCompromised adult human mesenchymal stem cells (hMSC) can impair cell therapy efficacy and further reverse ischemic recovery. However, in vitro assays require extended passage to characterize cells, limiting rapid assessment for therapeutic potency. Multinuclear magnetic resonance imaging and spectroscopy (MRI/S) provides near real-time feedback on disease progression and tissue recovery. Applied to ischemic stroke, 23Na MRI evaluates treatment efficacy within 24 h after middle cerebral artery occlusion, showing recovery of sodiu...
Source: Cell Research - July 28, 2022 Category: Cytology Authors: Shannon Helsper Xuegang Yuan F Andrew Bagdasarian Jacob Athey Yan Li Cesario V Borlongan Samuel C Grant Source Type: research

Magnetic Nanobubble Mechanical Stress Induces the Piezo1 ‐Ca2+‐BMP2/Smad Pathway to Modulate Neural Stem Cell Fate and MRI/Ultrasound Dual Imaging Surveillance for Ischemic Stroke
Magnetic nanobubbles (MNBs) assembled from magnetic nanoparticles are fabricated. When interacting with neural stem cells (NSCs), these MNB nanostructures can contract and expand with volumetric oscillation, leading to a change in intramembrane mechanical properties. Therefore, MNBs can serve as acoustic sensors to transduce Piezo1-Ca2+- triggered BMP2/Smad signals regulating NSC development and can be tracked using magnetic resonance and ultrasound dual imaging. AbstractNeural stem cells (NSCs) are used to treat various nervous system diseases because of their self-renewal ability and multidirectional differentiation pote...
Source: Small - June 9, 2022 Category: Nanotechnology Authors: Jing Li, Yao Zhang, Zhichao Lou, Mingxi Li, Lin Cui, Zhenrong Yang, Lijuan Zhang, Yu Zhang, Ning Gu, Fang Yang Tags: Research Article Source Type: research

Erratum to: Stem cell-derived extracellular vesicle therapy for acute brain insults and neurodegenerative diseases
This article was republished on 30 April 2022, to correct the online version of the article which displayed an incorrect References. After online publication of this article, the authors noticed an error in the missing reference section for the page 21 and the Figure 1. The correct statement of this article should have read as below. 1. Our pre-specified biomarker sub-study showed that circulating EVs were markedly increased immediately after intravenous injection of MSCs (10). In this study, the number of the circulating EVs varied among patients after the application of the same dose of MSCs, and was associated with moto...
Source: BMB Reports - April 27, 2022 Category: Biochemistry Authors: Oh Young Bang Ji-Eun Kim Source Type: research

Pages: 1  2  3  4  5  6