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Source: Cell Transplantation
Therapy: Stem Cell Therapy

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Total 87 results found since Jan 2013.

Fibrinogen reduction and motor function improvement by hematopoietic growth factor treatment in chronic stroke in aged mice: a treatment frequency study.
This study provides new insight into understanding of the potential contribution of SCF+G-CSF in both reducing the risk of recurrent ischemic stroke and enhancing stroke recovery. PMID: 26817662 [PubMed - as supplied by publisher]
Source: Cell Transplantation - January 26, 2016 Category: Cytology Authors: Liu Y, Popescu M, Longo S, Gao M, Wang D, McGillis S, Zhao LR Tags: Cell Transplant Source Type: research

Therapeutic effect of ligustilide-stimulated adipose-derived stem cells in a mouse thromboembolic stroke model.
Abstract Stroke is a result of cerebral ischemia that triggers a cascade of both physiological and biochemical events. No effective treatment is available for stroke; however, stem cells have potential for use in rescue from the effects of stroke. Adipose-derived stem cells (ADSCs) are an abundant source of adult stem cells; therefore, ADSC therapy can be considered as a future strategy for regenerative medicine. However, more research is required to improve the effectiveness of transplanted ADSCs as a treatment for stroke in the mouse stroke model. Ligustilide isolated from the herb Angelica sinensis exhibits a n...
Source: Cell Transplantation - January 18, 2016 Category: Cytology Authors: Chi K, Fu RH, Huang YC, Chen SY, Lin SZ, Huang PC, Lin PC, Chang FK, Liu SP Tags: Cell Transplant Source Type: research

Induction of neurorestoration from endogenous stem cells.
Abstract Neural stem cells persist in the subventricular zone lining the ventricle of the adult brain. The resident stem/progenitor cells can be stimulated in vivo by neurotrophic factors, hematopoietic growth factors, magnetic stimulation and/or physical exercise. In both animals and humans, the differentiation and survival of neurons arising from the subventricular zone may be also regulated by the trophic factors. The presence of stem/progenitor cells in the adult brain and the fact that the production of new neurons occurs at specific sites suggest a possibility for the treatment of otherwise incurable neurolo...
Source: Cell Transplantation - January 18, 2016 Category: Cytology Authors: Yu JH, Seo JH, Lee JY, Lee MY, Cho SR Tags: Cell Transplant Source Type: research

Recent progress in therapeutic strategy for ischemic stroke.
Abstract Possible strategies for treating stroke include neuroprotection in the acute phase of cerebral ischemia, and stem cell therapy in the chronic phase of cerebral ischemia. First, we studied temporal and spatial expression pattern of c-fos, hypoxia inducible factor-1α (HIF-1α), heat shock protein 70 (HSP70), and annexin V after 90 min of transient middle cerebral occlusion in rats, and concluded that there is a time window for neuroprotection from 12 to 48 h after ischemia. Secondly, we estimated the neuroprotective effect of glial cell line-derived neurotrophic factor (GDNF) by injecting sendai viral vect...
Source: Cell Transplantation - January 18, 2016 Category: Cytology Authors: Yamashita T, Abe K Tags: Cell Transplant Source Type: research

Stroke serum priming modulates characteristics of mesenchymal stromal cells by controlling the expression miRNA-20a.
Abstract Transplantation of mesenchymal stem cells (MSCs), expanded with fetal bovine serum (FBS), has some limitations, including a long culture period required to obtain sufficient stem cells. Priming of MSCs with serum from patients with ischemic stroke (stroke serum) increased the proliferation rate and the neurorestorative capacity of MSCs. We hypothesized that this novel priming method increases the proliferation rate of MSCs via the regulation of microRNAs (miRs). Thus, we investigated miR profiling in stroke serum primed MSCs and tested whether the regulation of certain miRs may affect the proliferation ra...
Source: Cell Transplantation - January 13, 2016 Category: Cytology Authors: Kim EH, Kim DH, Kim HR, Kim SY, Kim HH, Bang OY Tags: Cell Transplant Source Type: research

Induction of endothelial phenotype from Warton Jelly-derived MSC and comparison of their vaso- and neuro-protective potential with primary WJ-MSC in CA1 hippocampal region ex vivo.
Abstract Ischemic stroke results in violent impairment of tissue homeostasis leading to severe perturbation within the neurovascular unit (NVU) during recovery period. The aim of study was to assess the potential of mesenchymal stem cells (MSC) originating from Wharton jelly (WJ) to differentiate into functionally competent cells of endothelial lineage (WJ-EPC). Protective effect of either primary WJ-MSC or induced WJ-EPC was investigated and compared after oxygen-glucose deprivation (OGD) of hippocampal organotypic slices (OHC) in the indirect co-culture model. WJ-EPC, primed in EGM-2 media under 5% O2, acquired ...
Source: Cell Transplantation - December 31, 2015 Category: Cytology Authors: Obtulowicz P, Lech W, Strojek L, Sarnowska A, Domanska-Janik K Tags: Cell Transplant Source Type: research

Melatonin as an Antioxidant for Stroke Neuroprotection.
Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a hormone derived from the pineal gland that has wide range of clinical application. While melatonin was originally assessed as a hormone specializing in regulation of the normal circadian rhythm in mammals, it now has been shown to be an effective free radical scavenger and antioxidant. Current research has focused on Central Nervous System (CNS) disorders, stroke in particular, for potential melatonin-based therapeutics. As of now, the realm of potential therapy regimens is focused on three main treatments: exogenously delivered melatonin, pineal gland graftin...
Source: Cell Transplantation - October 22, 2015 Category: Cytology Authors: Watson N, Diamandis T, Gonzales-Portillo C, Reyes S, Borlongan CV Tags: Cell Transplant Source Type: research

Bio-Distribution of Infused Human Umbilical Cord Blood Cells in Alzheimer's Disease-Like Murine Model.
In this report, we followed the bioavailability of HUCBCs in AD-like transgenic PSAPP mice and non-transgenic Sprague-Dawley rats. HUCBCs were injected in tail veins of mice or rats at a single dose of 1 x 10(6) or 2.2 x 10(6) cells, respectively, prior to harvesting of tissues at 24 hours, 7 days, and 30 days after injection. For determination of HUCBC distribution, tissues from both species were subjected to total DNA isolation and PCR amplification of the gene for human glycerol-3-phosphate dehydrogenase. Our results show a relatively similar bio-distribution and retention of HUCBCs in both mouse and rat organs. HUCBCs ...
Source: Cell Transplantation - September 25, 2015 Category: Cytology Tags: Cell Transplant Source Type: research

Optogenetic Stimulation of Neural Grafts Enhances Neurotransmission and Downregulates the Inflammatory Response in Experimental Stroke Model.
Abstract Compelling evidence suggests that transplantation of neural stem cells (NSCs) from multiple sources ameliorates motor deficits after stroke. However, it is currently unknown to what extent the electrophysiological activity of grafted neural stem cell progeny participates in the improvement of motor deficits and whether excitatory phenotypes of the grafted cells are beneficial or deleterious to sensorimotor performances. To address this question, we used optogenetic tools to drive the excitatory outputs of the grafted NSCs and assess the impact on local circuitry and sensorimotor performance. We geneticall...
Source: Cell Transplantation - June 30, 2015 Category: Cytology Authors: Daadi MM, Klausner JQ, Bajar B, Goshen I, Lee-Messer C, Lee SY, Winge MC, Ramakrishnan C, Lo M, Sun G, Deisseroth K Tags: Cell Transplant Source Type: research

No pain, no gain: Lack of exercise obstructs neurogenesis.
In this study, we discussed how immobilization-induced disuse atrophy, using the hindlimb suspension model, affects neurogenesis in rats. The overarching hypothesis is that immobilization suppresses neurogenesis by reducing the circulating growth or trophic factors, such as vascular endothelial growth factor or brain-derived neurotrophic factor. That immobilization alters neurogenesis and stem cell differentiation in the CNS requires characterization of the stem cell microenvironment by examining the trophic and growth factors, as well as stressrelated proteins that have been implicated in exercise-induced neurogenesis. Al...
Source: Cell Transplantation - March 24, 2015 Category: Cytology Authors: Watson N, Ji X, Yasuhara T, Date I, Kaneko Y, Tajiri N, Borlongan CV Tags: Cell Transplant Source Type: research

Transplantation of human placenta-derived multipotent stem cells reduces ischemic brain injury in adult rats.
In this study, we examined the protective effect of hPDMC transplants in a rodent model of stroke. Adult male Sprague-Dawley rats were anesthetized. hPDMCs labeled with a vital dye of fluorescing microparticles, Dil, or vehicle were transplanted into 3 cortical areas adjacent to the right middle cerebral artery (MCA). Five minutes after grafting, the right MCA was transiently occluded for 60 min. Stroke animals receiving hPDMCs showed a significant behavioral improvement and reduction in lesion volume examined by T2-weighted images 4 days post stroke. Brain tissues were collected one day later. Human specific marker HuNu i...
Source: Cell Transplantation - February 9, 2015 Category: Cytology Authors: Wu KJ, Yu SJ, Chiang CW, Cho KH, Lee YW, Yen BL, Kuo LW, Wang Y Tags: Cell Transplant Source Type: research

Intranasal Delivery of Bone Marrow Mesenchymal Stem Cells Improved Neurovascular Regeneration and Rescued Neuropsychiatric Deficits after Neonatal Stroke in Rats.
Abstract Neonatal stroke is a major cause of mortality and long-term morbidity in infants and children. Currently very limited therapeutic strategies are available to protect the developing brain against ischemic damage and promote brain repairs for pediatric patients. Moreover, children who experienced neonatal stroke often have developmental social behavior problems. Cellular therapy using bone marrow mesenchymal stem cells (BMSCs) has emerged as a regenerative therapy after stroke. In the present investigation, neonatal stroke of postnatal day 7 (P7) rat pups was treated with non-invasive and brain specific int...
Source: Cell Transplantation - February 2, 2015 Category: Cytology Authors: Wei ZZ, Gu X, Ferdinand A, Lee JH, Ji X, Ji XM, Yu SP, Wei L Tags: Cell Transplant Source Type: research

Adipose Tissue Derived Stem Cells in Neural Regenerative Medicine.
In this study, several human clinical trials using ADSCs for neuronal disorders were investigated. It is suggested that ADSCs are one of the choices among various stem cells for translating into clinical application in the near future. PMID: 25647067 [PubMed - as supplied by publisher]
Source: Cell Transplantation - February 2, 2015 Category: Cytology Authors: Yeh DC, Chan TM, Harn HJ, Chiou TW, Chen HS, Lin ZS, Lin SZ Tags: Cell Transplant Source Type: research

Intra-arterial delivery of human bone marrow mesenchymal stem cells is a safe and effective way to treat cerebral ischemia in rats.
In this study, the therapeutic effects of bone marrow stem cells (BMSCs) delivered by intra-arterial (IA) and intravenous (IV) injection in a rat transient middle cerebral artery occlusion model (MCAO) are compared. Histological analysis demonstrated that the IA route bypasses the pulmonary system and directs the cells to the ischemic parts of the brain more efficiently. The BMSCs delivered via the IA route promoted angiogenesis and improved functional recovery. The cerebral blood flow (CBF) of the rats was monitored during the IA injection process. No reduction in CBF or microstrokes was detected. Brain perfusion and meta...
Source: Cell Transplantation - November 4, 2014 Category: Cytology Authors: Du S, Guan J, Mao G, Liu Y, Ma S, Bao X, Gao J, Feng M, Li G, Ma W, Yang Y, Zhao RC, Wang R Tags: Cell Transplant Source Type: research

A two-year follow-up study of co-transplantation with neural stem/precursor cells and mesenchymal stromal cells in ischemic stroke patients.
Abstract Stem cell therapy is an emerging therapeutic modality in the treatment of stroke. We assessed the safety and feasibility of the co-transplantation of neural stem/precursor cells (NSPCs) and mesenchymal stromal cells (MSCs) in patients with ischemic stroke. Eight patients were enrolled in this study. All patients had a hemisphere with infarct lesions located on one side of the territories of the cerebral middle or anterior arteries as revealed with cranial magnetic resonance imaging (MRI). The patients received one of the following two types of treatment: the first treatment involved 4 intravenous injectio...
Source: Cell Transplantation - October 20, 2014 Category: Cytology Authors: Qiao LY, Huang FJ, Zhao M, Xie JH, Shi J, Wang J, Lin XZ, Zuo H, Wang YL, Geng TC Tags: Cell Transplant Source Type: research