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Source: Cell Transplantation
Therapy: Stem Cell Therapy

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Total 87 results found since Jan 2013.

Mesenchymal Stem Cells Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research.
Abstract Exogenous stem cell therapy (SCT) has been recognized recently as a promising neuroregenerative strategy to augment recovery in stroke survivors. Mesenchymal stem cells (MSCs) are the primary source of stem cells used in the majority of both pre-clinical and clinical studies in stroke. In the absence of evidence-based guidelines on the use of SCT in stroke patients, understanding the progress of MSC research across published studies will assist researchers and clinicians in better achieving success in translating research. We conducted a systematic review on published literature using MSCs in both pre-cli...
Source: Cell Transplantation - October 22, 2018 Category: Cytology Authors: Zheng H, Zhang B, Chhatbar PY, Dong Y, Alawieh A, Lowe F, Hu X, Feng W Tags: Cell Transplant Source Type: research

Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke.
Abstract Stroke is a major disease that leads to high mortality and morbidity. Given the ageing population and the potential risk factors, the prevalence of stroke and socioeconomic burden associated with stroke are expected to increase. During the past decade, both prophylactic and therapeutic strategies for stroke have made significant progress. However, current therapies still cannot adequately improve the outcomes of stroke and may not apply to all patients. One of the significant advances in modern medicine is cell-derived neurovascular regeneration and neuronal repair. Progress in stem cell biology has great...
Source: Cell Transplantation - September 25, 2018 Category: Cytology Authors: Wang F, Tang H, Zhu J, Zhang JH Tags: Cell Transplant Source Type: research

Placenta-Derived Cells for Acute Brain Injury.
Abstract Acute brain injury resulting from ischemic/hemorrhagic or traumatic damage is one of the leading causes of mortality and disability worldwide and is a significant burden to society. Neuroprotective options to counteract brain damage are very limited in stroke and traumatic brain injury (TBI). Given the multifaceted nature of acute brain injury and damage progression, several therapeutic targets may need to be addressed simultaneously to interfere with the evolution of the injury and improve the patient's outcome. Stem cells are ideal candidates since they act on various mechanisms of protection and repair...
Source: Cell Transplantation - January 1, 2018 Category: Cytology Authors: Pischiutta F, Sammali E, Parolini O, Carswell HVO, Zanier ER Tags: Cell Transplant Source Type: research

Human Umbilical Cord Mesenchymal Stem Cells Preserve Adult Newborn Neurons and Reduce Neurological Injury after Cerebral Ischemia by Reducing the Number of Hypertrophic Microglia/Macrophages.
Abstract Microglia are the first source of a neuroinflammatory cascade, which seems to be involved in every phase of stroke-related neuronal damage. Two weeks after transient middle cerebral artery occlusion (MCAO), vehicle-treated rats displayed higher numbers of total ionized calcium-binding adaptor molecule 1 (Iba-1)-positive cells, greater cell body areas of Iba-1-positive cells, and higher numbers of hypertrophic Iba-1-positive cells (with a cell body area over 80 μm2) in the ipsilateral ischemic brain regions including the frontal cortex, striatum, and parietal cortex. In addition, MCAO decreased the number...
Source: Cell Transplantation - November 1, 2017 Category: Cytology Authors: Lin W, Hsuan YC, Lin MT, Kuo TW, Lin CH, Su YC, Niu KC, Chang CP, Lin HJ Tags: Cell Transplant Source Type: research

In Vivo Long-Term Tracking of Neural Stem Cells Transplanted into an Acute Ischemic Stroke model with Reporter Gene-Based Bimodal MR and Optical Imaging.
Abstract Transplantation of neural stem cells (NSCs) is emerging as a new therapeutic approach for stroke. Real-time imaging of transplanted NSCs is essential for successful cell delivery, safety monitoring, tracking cell fate and function, and understanding the interactions of transplanted cells with the host environment. Magnetic resonance imaging (MRI) of magnetic nanoparticle-labeled cells has been the most widely used means to track stem cells in vivo. Nevertheless, it does not allow for the reliable discrimination between live and dead cells. Reporter gene-based MRI was considered as an alternative strategy ...
Source: Cell Transplantation - October 1, 2017 Category: Cytology Authors: Zhang F, Duan X, Lu L, Zhang X, Chen M, Mao J, Cao M, Shen J Tags: Cell Transplant Source Type: research

Neuronal Cell Sheets of Cortical Motor Neuron Phenotype Derived from Human iPSCs.
Abstract Transplantation of stem cells that differentiate into more mature neural cells brings about functional improvement in preclinical studies of stroke. Previous transplant approaches in the diseased brain utilized injection of the cells in a cell suspension. In addition, neural stem cells were preferentially used for grafting. However, these cells had no specific relationship to the damaged tissue of stroke and brain injury patients. The injection of cells in a suspension destroyed the cell-cell interactions that are suggested to be important for promoting functional integrity of cortical motor neurons. In o...
Source: Cell Transplantation - August 1, 2017 Category: Cytology Authors: Suzuki N, Arimitsu N, Shimizu J, Takai K, Hirotsu C, Ueda Y, Wakisaka S, Fujiwara N, Suzuki T Tags: Cell Transplant Source Type: research

Evaluation of Parametric Response Mapping to Assess Therapeutic Response to Human Mesenchymal Stem Cells after Experimental Stroke.
Abstract Stroke is the leading cause of disability in adults. After the very narrow time frame during which treatment by thrombolysis and mechanical thrombectomy is possible, cell therapy has huge potential for enhancing stroke recovery. Accurate analysis of the response to new therapy using imaging biomarkers is needed to assess therapeutic efficacy. The aim of this study was to compare 2 analysis techniques: the parametric response map (PRM), a voxel-based technique, and the standard whole-lesion approach. These 2 analyses were performed on data collected at 4 time points in a transient middle cerebral artery oc...
Source: Cell Transplantation - August 1, 2017 Category: Cytology Authors: He R, Moisan A, Detante O, Rémy C, Krainik A, Barbier EL, Lemasson B Tags: Cell Transplant Source Type: research

Evaluation of parametric response mapping to assess therapeutic response to human mesenchymal stem cells after experimental stroke.
Abstract Stroke is the leading cause of disability in adults. After the very narrow time frame during which treatment by thrombolysis and mechanical thrombectomy is possible, cell therapy has huge potential for enhancing stroke recovery. Accurate analysis of the response to new therapy, using imaging biomarkers, is needed to assess therapeutic efficacy. The aim of this study is to compare two analysis techniques: the parametric response map (PRM), a voxel-based technique, and the standard whole-lesion approach. These two analyses were performed on data collected at 4 time points in a transient middle cerebral arte...
Source: Cell Transplantation - May 9, 2017 Category: Cytology Authors: He R, Moisan A, Detante O, Rémy C, Krainik A, Barbier EL, Lemasson B Tags: Cell Transplant Source Type: research

Neuronal cell sheet of cortical motor neuron phenotype derived from human iPS cells.
Abstract <p>Transplantation of stem cells which differentiate into more mature neural cells brings about functional improvement in pre-clinical studies of stroke. Previous transplant approaches in diseased brain have utilized injection of the cells in a cell suspension. In addition, neural stem cells were preferentially used as graft. However, these cells had no specific relationship to the damaged tissue of stroke patients and brain injury. The injection of cells in a suspension destroyed the cell-cell interactions that are suggested to be important for promoting functional integrity as cortical motor neuro...
Source: Cell Transplantation - March 17, 2017 Category: Cytology Authors: Suzuki N, Arimitsu N, Shimizu J, Takai K, Hirotsu C, Takada E, Ueda Y, Wakisaka S, Fujiwara N, Suzuki T Tags: Cell Transplant Source Type: research

GSK-3 β Inhibition Induced Neuroprotection, Regeneration and Functional Recovery after Intracerebral Hemorrhagic Stroke.
GSK-3β Inhibition Induced Neuroprotection, Regeneration and Functional Recovery after Intracerebral Hemorrhagic Stroke. Cell Transplant. 2017 Feb 14;: Authors: Zhao Y, Wei ZZ, Zhang JY, Zhang Y, Won S, Sun J, Yu SP, Li J, Wei L Abstract Hemorrhagic stroke is a devastating disease that lacks effective therapies. In the present investigation, we tested 6-bromoindirubin-3'-oxime (BIO) as a selective glycogen synthase kinase-3β (GSK-3β) inhibitor in a mouse model of intracerebral hemorrhage (ICH). ICH was induced by injection of collagenase IV into the striatum of 8 to 10-week old C57BL/6 mice. BIO (8 ...
Source: Cell Transplantation - February 13, 2017 Category: Cytology Authors: Zhao Y, Wei ZZ, Zhang JY, Zhang Y, Won S, Sun J, Yu SP, Li J, Wei L Tags: Cell Transplant Source Type: research

Human dental pulp stem cells are more effective than human bone marrow-derived mesenchymal stem cells in cerebral ischemic injury.
Abstract We compared the therapeutic effects and mechanism of transplanted human dental pulp stem cells (hDPSCs) and human bonemarrow-derived mesenchymal stem cells (hMSCs) in a stroke model of rats and an &lt;i&gt;in vitro&lt;/i&gt; ischemic model. Both hDPSCs- and hMSCs- intravenously injected rats 24&amp;#8201;h after middle cerebral artery occlusion showed improved functional recovery and reduced infarct volume versus control rats, but the hDPSCs group showed greater reduction in infarct volume than hMSCs. The positive area for the endothelial cell marker was greater in the lesion boundary ...
Source: Cell Transplantation - January 19, 2017 Category: Cytology Authors: Song M, Lee JH, Bae J, Bu Y, Kim EC Tags: Cell Transplant Source Type: research

Novel therapeutic transplantation of induced neural stem cells for stroke.
In this study, we used a mouse model of transient middle cerebral artery occlusion (tMCAO). iNSCs (5 × 105) were injected directly into the ipsilateral striatum and cortex 24 hours after tMCAO. Histological analysis was performed at 7 days, 28 days, and 8 months after tMCAO. We found that iNSC transplantation successfully improved the survival rate of stroke model mice with significant functional recovery from the stroke. The fate of engrafted iNSCs was that the majority of iNSCs had differentiated into astroglial cells but not into neural cells in both the sham-operated brain and the post-stroke brain without forming a t...
Source: Cell Transplantation - September 19, 2016 Category: Cytology Authors: Yamashita T, Liu W, Matsumura Y, Miyagi R, Zhai Y, Kusaki M, Hishikawa N, Ohta Y, Kim SM, Kwak TH, Han DW, Abe K Tags: Cell Transplant Source Type: research

Amelioration of Ischemic Brain Injury in Rats with Human Umbilical Cord Blood Stem Cells: Mechanisms of Action.
Abstract Despite the high prevalence and devastating outcome, there remain few options for treatment of ischemic stroke. Currently available treatments are limited by a short time window for treatment and marginal efficacy when used. We have tested a human umbilical cord blood-derived stem cell line that has shown both a significant reduction in stroke infarct volume as well as improved functional recovery following stroke in the rat. In the present study we address the mechanism of action and compared therapeutic efficacy of high vs. low passage non-hematopoietic umbilical cord blood stem cells (nh-UCBSCs). Using...
Source: Cell Transplantation - March 17, 2016 Category: Cytology Authors: Stone LL, Xiao F, Rotshafer J, Nan Z, Juliano M, Sanberg CD, Sanberg PR, Kuzmin-Nichols N, Grande A, Cheeran MC, Low WC Tags: Cell Transplant Source Type: research

Intravenous injection of clinical grade human MSCs after experimental stroke: functional benefit and microvascular effect.
Abstract Stroke is the leading cause of disability in adults. Many current clinical trials use an intravenous (IV) administration of human mesenchymal stromal/stem cells (hMSCs). This autologous graft requires a delay for ex vivo expansion of cells. We followed microvascular effects and mechanisms of action involved after an IV injection of hMSCs at a subacute phase of stroke. Rats underwent a transient middle cerebral artery occlusion (MCAo) or a surgery without occlusion (sham) at day 0 (D0). At D8, rats received an IV injection of 3 million hMSCs or PBSglutamine. In a longitudinal behavioral follow-up, we showe...
Source: Cell Transplantation - February 26, 2016 Category: Cytology Authors: Moisan A, Favre I, Rome C, De Fraipont F, Grillon E, Coquery N, Mathieu H, Mayan V, Naegele B, Hommel M, Richard MJ, Barbier EL, Remy C, Detante O Tags: Cell Transplant Source Type: research

Breaking the blood brain barrier to aid stem cell therapeutics in the chronic stroke brain.
Abstract Blood brain barrier (BBB) permeabilizers, such as mannitol, can facilitate peripherally delivered stem cells to exert the therapeutic benefits on the stroke brain. Although this BBB permeation-aided stem cell therapy has been demonstrated in the acute stage of stroke, such BBB permeation in the chronic stage of the disease remains to be examined. Adult Sprague-Dawley rats initially received sham surgery or experimental stroke via the one-hour middle cerebral artery occlusion (MCAo) model. At one month after the MCAo surgery, stroke animals were randomly assigned to receive human umbilical cord stem cells ...
Source: Cell Transplantation - February 15, 2016 Category: Cytology Authors: Tajiri N, Lee JY, Acosta S, Sanberg PR, Borlongan CV Tags: Cell Transplant Source Type: research