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Source: Cell Transplantation
Therapy: Stem Cell Therapy
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Total 87 results found since Jan 2013.
Coating-Free Culture Medium for Establishing and Maintaining Human Induced Pluripotent Stem Cells
In this study, we develop an innovative coating-free medium for expanding hPSCs. The xenofree medium supports the weekend-free culture and competitive growth of hPSCs on several cell culture plastics without an additional pre-coating process. The pluripotent stemness of the expanded cells is stably sustained for more than 10 passages, featured with high pluripotent marker expressions, normal karyotyping, and differentiating capacity for three germ layers. The expression levels of some integrins are reduced, compared with those of the hPSCs on Matrigel. This medium also successfully supports the clonal expansion and induced...
Source: Cell Transplantation - September 12, 2023 Category: Cytology Authors: Chih-Yao Lin Yu-Yun Ching Shih-Fang Wu Yi-Ko Lee Hueng-Chuen Fan Liang-Yu Su Su-Yi Tsai Yu-Ching Chen Ching-I Shen Hong-Lin Su Source Type: research
Comparative Analysis of the Results of Stroke Treatment With Multiple Administrations of Wharton's Jelly Mesenchymal Stem Cells-Derived HE-ATMP and Standard Conservative Treatment: Case Series Study
Cell Transplant. 2023 Jan-Dec;32:9636897231195145. doi: 10.1177/09636897231195145.ABSTRACTStroke remains still the leading cause of long-term disability worldwide. Although interventions such as early reperfusion, intravenous thrombolysis, and endovascular revascularization have shown neurological benefit in stroke patients, there is still lack of effective treatment enabling regeneration of nervous tissue after cerebral ischemic episodes. Cell therapy is an evolving opportunity for stroke survivors with residual neurological deficits. The purpose of this study was to evaluate safety and potential efficacy of multiple admi...
Source: Cell Transplantation - August 30, 2023 Category: Cytology Authors: Olga Milczarek Jakub Swad źba Patrycja Swad źba Anna Starowicz-Filip Roger M Krzy żewski Stanis ław Kwiatkowski Marcin Majka Source Type: research
Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review
Cell Transplant. 2023 Jan-Dec;32:9636897231184596. doi: 10.1177/09636897231184596.ABSTRACTThe immense neuroinflammation induced by multiple sclerosis (MS) promotes a favorable environment for ischemic stroke (IS) development, making IS a deadly complication of MS. The overlapping inflammation in MS and IS is a prelude to the vascular pathology, and an inherent cell death mechanism that exacerbates neurovascular unit (NVU) impairment in the disease progression. Despite this consequence, no therapies focus on reducing IS incidence in patients with MS. To this end, the preclinical and clinical evidence we review here argues f...
Source: Cell Transplantation - July 29, 2023 Category: Cytology Authors: Molly Monsour Jonah Gordon Gavin Lockard Cesar V Borlongan Source Type: research
Stem Cell Therapies for Intracerebral Hemorrhage: Review of Preclinical and Clinical Studies
Cell Transplant. 2023 Jan-Dec;32:9636897231158153. doi: 10.1177/09636897231158153.ABSTRACTDespite recent developments in the treatments for ischemic stroke, such as tissue plasminogen activator (t-PA) and thrombectomy, effective therapies for intracerebral hemorrhage (ICH) remain scarce. Stem cell therapies have attracted considerable attention owing to their potential neuro-regenerative ability; preclinical and clinical studies have been conducted to explore strategies for achieving functional recovery following ICH. In this review, we summarize the findings of preclinical studies on stem cell therapies of ICH, with a foc...
Source: Cell Transplantation - February 24, 2023 Category: Cytology Authors: Soichiro Takamiya Masahito Kawabori Miki Fujimura Source Type: research
Exosomes Derived From Mesenchymal Stem Cells Pretreated With Ischemic Rat Heart Extracts Promote Angiogenesis via the Delivery of DMBT1
Cell Transplant. 2022 Jan-Dec;31:9636897221102898. doi: 10.1177/09636897221102898.ABSTRACTMesenchymal stem cell-derived exosomes (MSC-Exos) have been shown to promote angiogenesis. Treating MSCs with ischemic rat brain extracts was sufficient to augment their benefits in stroke. However, no similar analyses of ischemic heart extracts have been performed to date. We aim to determine whether MSC-Exos derived from MSCs pretreated with ischemic rat heart extract were able to promote angiogenesis and to clarify underlying mechanisms. ELISA (enzyme-linked immunosorbent assay) of heart extracts revealed a significant increase of ...
Source: Cell Transplantation - June 21, 2022 Category: Cytology Authors: Yi Xiao Ye Zhang Yuzhang Li Nanyin Peng Qin Liu Danyang Qiu Justin Cho Cesario V Borlongan Guolong Yu Source Type: research
Final Results of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells in Acute Ischemic Stroke (AMASCIS): A Phase II, Randomized, Double-Blind, Placebo-Controlled, Single-Center, Pilot Clinical Trial
We report the final trial results after 24 months of follow-up. Recruitment began in December 2014 and stopped in December 2017 after 19 of 20 planned patients were included. Six patients did not receive study treatment: two due to technical issues and four for acquiring exclusion criteria after randomization. The final study sample was composed of 13 patients (4 receiving AD-MSCs and 9 placebo). One patient in the placebo group died within the first week after study treatment delivery due to sepsis. Two non-treatment-related serious AEs occurred in the AD-MSC group and nine in the placebo group. The total number of AEs an...
Source: Cell Transplantation - March 18, 2022 Category: Cytology Authors: Elena de Celis-Ruiz Blanca Fuentes Mar ía Alonso de Leciñana Mar ía Gutiérrez-Fernández Alberto M Borobia Raquel Guti érrez-Zúñiga Gerardo Ruiz-Ares Laura Otero-Ortega Fernando Laso-Garc ía Mari Carmen G ómez-de Frutos Exuperio D íez-Tejedor Source Type: research
