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A new era of macrophage-based cell therapy
Experimental & Molecular Medicine, Published online: 01 September 2023; doi:10.1038/s12276-023-01068-zTreating disease with the white blood cells called macrophages, in some cases genetically modified, could become an effective clinical option for a range of diseases. Macrophages are cells of the innate (non-specific) immune system that can destroy diseased cells or damaging materials. They can also enhance tissue repair by releasing growth factors and anti-inflammatory molecules. Seung Hyeok Seok and colleagues at Seoul National University in South Korea review the laboratory research and clinical trials that are inve...
Source: Experimental and Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Yi Rang Na Sang Wha Kim Seung Hyeok Seok Source Type: research

Induction of Nanog in neural progenitor cells for adaptive regeneration of ischemic brain
Experimental & Molecular Medicine, Published online: 14 November 2022; doi:10.1038/s12276-022-00880-3The NANOG regulatory protein promotes neuronal regeneration by prompting the self-renewal of progenitor cells following a stroke due to blood vessel blockage (ischemic stroke). NANOG is involved in cellular plasticity and reprogramming, including the maintenance of pluripotent stem cells. Gyung-Ah Jung at the Catholic University of Korea in Seoul, South Korea, and co-workers have demonstrated that NANOG is also critical to the brain’s adaptive response to ischemic stroke. They found that NANOG is preferentially expres...
Source: Experimental and Molecular Medicine - November 14, 2022 Category: Molecular Biology Authors: Gyung-Ah Jung Jin-A Kim Hwan-Woo Park Hyemi Lee Mi-Sook Chang Kyung-Ok Cho Byeong-Wook Song Hyun-Ju Kim Yunhee Kim Kwon Il-Hoan Oh Source Type: research

Blood Flow Restriction Exercise Attenuates the Exercise-Induced Endothelial Progenitor Cell Response in Healthy, Young Men
Conclusion In summary, this is the first study to show that BFR exercise did not augment EPC response to exercise, and in fact blunted the EPC response to low load unilateral KE exercise in young, healthy males. Ethics Statement This study was carried out in accordance with the recommendations of Edinburgh Napier University Research and Ethics Governance Committee. The study was ethically approved by Edinburgh Napier University Research and Ethics Governance Committee. All participants gave written informed consent in accordance with the Declaration of Helsinki. Author Contributions MR, RM, AP, CW, GF-J designed the s...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Combining Human Umbilical Cord Blood Cells With Erythropoietin Enhances Angiogenesis/Neurogenesis and Behavioral Recovery After Stroke
In conclusion, our results suggest that hUCBC infusion in combination with EPO administration demonstrates therapeutic efficacy in the treatment of stroke-induced injury by promoting neurogenesis and angiogenesis. Further research that delineates the therapeutic mechanism of systemically administered hUCBC and EPO is required. Ethics Statement All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the U. S. National Institutes of Health and were approved by CHA University Institutional Animal Care & Use Com...
Source: Frontiers in Neurology - April 9, 2019 Category: Neurology Source Type: research