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Total 1021 results found since Jan 2013.

How To Avoid China ’ s Medicine Monopoly
I want to share a shocking statistic with you… Around 80% of all the pharmaceuticals sold in America — both prescription and over-the-counter — are manufactured in China. I’m talking about drugs for Parkinson’s and Alzheimer’s, blood pressure and blood thinners, diuretics, aspirin, antibiotics, and a big chunk of the world’s insulin and diabetes drugs — just to name a few.1 We don’t even make penicillin anymore. The last penicillin plant in the U.S. closed its doors in 2004. Americans who rely on medicine are now almost entirely at the mercy of a country whose relations with the U.S. have become more ...
Source: Al Sears, MD Natural Remedies - September 19, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Source Type: news

Atherosclerosis as a Risk Factor for IBD: A Population-Based Case-Control Study
CONCLUSIONS: A history of an atherosclerotic-related condition is associated with increased odds of developing IBD, particularly among older adults. Future studies should investigate whether drugs targeting atherosclerotic-related inflammation may prevent IBD in higher-risk individuals.PMID:37721310 | DOI:10.14309/ajg.0000000000002502
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Adam S Faye Jordan Axelrad Jiangwei Sun Jonas Halfvarson Jonas S öderling Ola Ol én Jonas F Ludvigsson Source Type: research

Association of Coronary Artery Calcium Detected by Routine Ungated CT Imaging With Cardiovascular Outcomes
CONCLUSIONS: Incidental CAC ≥100 was associated with an increased risk of all-cause death and adverse cardiovascular outcomes, beyond traditional risk factors. DL-CAC from routine non-ECG-gated CTs identifies patients at increased cardiovascular risk and holds promise as a tool for opportunistic screening to facilitate earlier intervention.PMID:37704309 | DOI:10.1016/j.jacc.2023.06.040
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Allison W Peng Ramzi Dudum Sneha S Jain David J Maron Bhavik N Patel Nishith Khandwala David Eng Akshay S Chaudhari Alexander T Sandhu Fatima Rodriguez Source Type: research

Microfluidic-to-macrofluidic: A simple < em > in vitro < /em > model of atherosclerosis induced by fluidic stimulation
Biomicrofluidics. 2023 Aug 29;17(4):044106. doi: 10.1063/5.0155267. eCollection 2023 Jul.ABSTRACTAtherosclerosis is the narrowing of the arteries due to the formation of fatty plaques, which is the main cause of myocardial infarction and stroke. It is important to develop an in vitro model that can combine multiple-type cell co-culture, vessel wall-like structure, and fluid condition to simulate the processes of atherosclerosis. Herein, we used a simple microfluidic chip made of three polydimethylsiloxane layers to co-culture endothelial and smooth muscle cells in a flat rectangular microchannel. After being connected with...
Source: Atherosclerosis - September 4, 2023 Category: Cardiology Authors: Jingang Cui Wei Jiang Jilei Su Jiazhen Zhang Yongliang Yu Yongsheng Ding Source Type: research

Silent Myocardial Infarction: A Case Report
We present a case of a 59-year-old overweight woman with prediabetes, primary hypertension, and hypercholesterolemia who presented for herpes zoster (HZ) follow-up; she reported having skipped heartbeats and heart rate fluctuations during the review of systems. On further workup, ECG revealed low voltage QRS complexes, flat QRS complexes, flat T waves, and pathological Q waves, suggesting the diagnosis of SMI. Based on the identified risk factors, including high BMI, prediabetes, primary hypertension, hypercholesterolemia, HZ, and newly diagnosed SMI, the patient was advised to continue with lisinopril 20 mg daily, prescri...
Source: Herpes - August 28, 2023 Category: Infectious Diseases Authors: Maria V Kolesova Suzanne Minor Source Type: research

Fixed dose combination therapies in primary cardiovascular disease prevention in different groups: an individual participant meta-analysis
Conclusions In participants with intermediate cardiovascular risk, FDCs produce larger cardiovascular benefits in older individuals, which appear greater with aspirin. Trial registration number HOPE-3, NCT00468923; TIPS-3, NCT016464137; PolyIran, NCT01271985.
Source: Heart - August 24, 2023 Category: Cardiology Authors: Dagenais, G. R., Pais, P., Gao, P., Roshandel, G., Malekzadeh, R., Joseph, P., Yusuf, S. Tags: Cardiac risk factors and prevention Source Type: research

Evaluation of Large-Scale Proteomics for Prediction of Cardiovascular Events
CONCLUSIONS AND RELEVANCE: A protein risk score was significantly associated with ASCVD events in primary and secondary event populations. When added to clinical risk factors, the protein risk score and polygenic risk score both provided statistically significant but modest improvement in discrimination.PMID:37606673 | DOI:10.1001/jama.2023.13258
Source: Atherosclerosis - August 22, 2023 Category: Cardiology Authors: Hannes Helgason Thjodbjorg Eiriksdottir Magnus O Ulfarsson Abhishek Choudhary Sigrun H Lund Erna V Ivarsdottir Grimur Hjorleifsson Eldjarn Gudmundur Einarsson Egil Ferkingstad Kristjan H S Moore Narimon Honarpour Thomas Liu Huei Wang Thomas Hucko Marc S S Source Type: research

Association between Non-Lipid Residual Risk Factors and Cardiovascular Events in Patients with Stable Coronary Artery Disease Treated with Pitavastatin: An Observation from the REAL-CAD Study
CONCLUSIONS: In patients with stable CAD treated with pitavastatin and who achieved guidelines-directed levels of LDL-C, eGFR and HbA1c were independently associated with adverse events, suggesting that renal function and glycemic control could be residual non-lipid therapeutic targets after statin therapy.PMID:37574272 | DOI:10.5551/jat.64304
Source: Journal of Atherosclerosis and Thrombosis - August 13, 2023 Category: Cardiology Authors: Kiwamu Kamiya Makoto Takei Toshiyuki Nagai Toru Miyoshi Hiroshi Ito Yoshihiro Fukumoto Hitoshi Obara Tatsuyuki Kakuma Ichiro Sakuma Hiroyuki Daida Satoshi Iimuro Hiroaki Shimokawa Takeshi Kimura Ryozo Nagai Toshihisa Anzai REAL-CAD study investigators Source Type: research

Low-Dose Colchicine for Secondary Prevention of Coronary Artery Disease: JACC Review Topic of the Week
J Am Coll Cardiol. 2023 Aug 15;82(7):648-660. doi: 10.1016/j.jacc.2023.05.055.ABSTRACTAmong statin-treated patients, inflammation assessed by means of high-sensitivity C-reactive protein (hsCRP) is a more powerful determinant of cardiovascular death and all-cause mortality than low-density-lipoprotein cholesterol (LDL-C). Several therapies that target residual inflammatory risk significantly reduce vascular event rates. For coronary artery disease patients already taking guideline-directed medical care, including statins, low-dose colchicine (0.5 mg/d orally) has been shown to safely lower major adverse cardiovascular even...
Source: Atherosclerosis - August 9, 2023 Category: Cardiology Authors: Kyle Nelson Valentin Fuster Paul M Ridker Source Type: research