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Revisiting Transcranial Light Stimulation as a Stroke Therapeutic —Hurdles and Opportunities
AbstractNear-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are many lingering questions and lessons that can be learned. In this review, we summarize the putative mechanism of light stimulation in the setting of stroke, highlight barriers, and challenges during the translational process, and evaluate light stimulation parameters, dosages and safety issues, choice of outcomes, effect size, and patient selection criteria. In the e...
Source: Translational Stroke Research - November 12, 2022 Category: Neurology Source Type: research

A Novel Method to Promote Behavioral Improvement and Enhance Mitochondrial Function Following An Embolic Stroke.
This study demonstrates that the combination of TLT-tPA enhances ATP production, and suggests that tPA-induced reperfusion in combination with TLT neuroprotection therapy may optimally protect viable cells in the cortex measured using ATP levels as a marker. PMID: 27180104 [PubMed - as supplied by publisher]
Source: Brain Research - May 10, 2016 Category: Neurology Authors: Lapchak PA, Boitano PD Tags: Brain Res Source Type: research

Current Therapeutic Options in Sturge Weber Syndrome
Sturge-Weber syndrome is a vascular malformation syndrome consisting of a facial port-wine birthmark associated with malformed leptomeningeal blood vessels and a choroid “angioma” of the eye. It is a rare neurocutaneous disorder that occurs sporadically, is not inherited, and is caused by a somatic mosaic mutation in GNAQ. Patients with Sturge-Weber syndrome brain involvement typically present in infancy with seizures, strokes and stroke-like episodes, and a range of neurological impairments. Standard treatment includes laser therapy for the birthmark, control of glaucoma through eye drops or surgery, and the use of anticonvulsants.
Source: Seminars in Pediatric Neurology - October 29, 2015 Category: Neurology Authors: Anne Comi Source Type: research

Transcranial Laser Therapy in Acute Stroke Treatment: Results of Neurothera Effectiveness and Safety Trial 3, a Phase III Clinical End Point Device Trial Major Clinical Trial
Conclusions— Once the results of the interim futility analysis became available, all study support was immediately withdrawn by the capital firms behind PhotoThera, and the company was dissolved. Proper termination of the trial was difficult but was finally achieved through special efforts by former employees of PhotoThera, the CRO Parexel and members of the steering and the safety committees. We conclude that transcranial laser therapy does not have a measurable neuroprotective effect in patients with acute ischemic stroke when applied within 24 hours after stroke onset. Clinical Trial Registration— URL: http...
Source: Stroke - October 27, 2014 Category: Neurology Authors: Hacke, W., Schellinger, P. D., Albers, G. W., Bornstein, N. M., Dahlof, B. L., Fulton, R., Kasner, S. E., Shuaib, A., Richieri, S. P., Dilly, S. G., Zivin, J., Lees, K. R., for the NEST 3 Committees and Investigators, Broderick, Ivanova, Johnston, Norrvin Tags: Acute Cerebral Infarction Major Clinical Trial Source Type: research

Stroke: Transcranial laser therapy for stroke fails futility analysis
Nature Reviews Neurology 10, 611 (2014). doi:10.1038/nrneurol.2014.200 A phase III trial of transcranial laser therapy has been discontinued after an interim analysis found no effect of laser therapy on patients' disability after ischaemic stroke. The transcranial laser device used in the trial was purported to provide energy to hypoxic mitochondria via near-infrared
Source: Nature Reviews Neurology - October 21, 2014 Category: Neurology Tags: Research Highlight Source Type: research

Safety of tPA + Transcranial Emission of Low-Energy Lasers for Acute Stroke Recovery - Results (P4.219)
Conclusion: Transcranial Laser in this small exploratory study was well tolerated in combination with IV tPA. Larger studies are needed to explore if the combination of LASER therapy plus tPA is safe and shows better outcome than IV tPA alone.Study supported by NIH Grant P50 NS044148Clinical Trial Registry: NCT01220739Disclosure: Dr. Hemmen has nothing to disclose. Dr. Raman has nothing to disclose. Dr. Sen has received personal compensation for activities with Genentech Inc., Sanofi Aventis Pharmaceutical Inc., Bristol-Myers Squibb Co., and Boehringer Ingelheim Pharmaceuticals Inc. Dr. Sen has received research support fr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Hemmen, T., Raman, R., Sen, S., Geraghty, M., Rapp, K., Richeri, S., Meyer, B., Zivin, J., Fanale, C. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Thrombolysis Source Type: research

Transcranial Laser Therapy and Infarct Volume Brief Reports
Conclusions— TLT was not associated with a reduction in overall or cortical infarct volume as measured on computed tomography in the subacute phase.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Kasner, S. E., Rose, D. Z., Skokan, A., Walker, M. G., Shi, J., Streeter, J., the NEST-2 Steering Committee and Investigators Tags: Acute Cerebral Infarction, Neuroprotectors Brief Reports Source Type: research