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Hyperbaric oxygen and focused rehabilitation program: a feasibility study in improving upper limb motor function after stroke
Applied Physiology, Nutrition, and Metabolism, Ahead of Print. Neuroplasticity and recovery after stroke can be enhanced by a rehabilitation program pertinent to upper limb motor function exercise and mental imagery (EMI) as well as hyperbaric oxygen therapy (HBOT). We assessed feasibility and safety of the combined approach utilizing both HBOT and EMI, and to derive preliminary estimates of its efficacy. In this randomized controlled trial, 27 patients with upper extremity hemiparesis at 3 –48 months after stroke were randomized to receive either a complementary rehabilitation program of HBOT-EMI (intervention group), o...
Source: Applied Physiology, Nutrition, and Metabolism - June 23, 2020 Category: Physiology Authors: S. Schiavo D. Richardson D. Santa Mina S. Buryk-Iggers J. Uehling J. Carroll H. Clarke C. Djaiani M. Gershinsky R. Katznelson Source Type: research

Hyperbaric oxygenation and 20 ‐hydroxyeicosatetreanoic acid inhibition reduce stroke volume in female diabetic Sprague–Dawley rats
New Findings What is the central question of this study? Is there a beneficial effect and what are the mechanisms of acute and multiple hyperbaric oxygenation (HBO2) exposures on the outcome of cerebral tissue injury induced by a transient middle cerebral artery occlusion model in diabetic female rats? Are 20‐hydroxyeicosatetreanoic acid and epoxyeicosatrienoic acids involved? What is the main finding and its importance? Equal reduction of cortical and total infarct size in rats treated with HBO2 and HET0016 (20‐hydroxyeicosatetreanoic acid production inhibitor) and significant mRNA upregulation of epoxyeicosatrienoic...
Source: Experimental Physiology - November 2, 2017 Category: Physiology Authors: Mihael Mi šir, Marija Renić, Sanja Novak, Martina Mihalj, Anita Ćosić, Monika Vesel, Ines Drenjančević Tags: Research Paper Source Type: research

Sirt1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats.
Abstract Hyperbaric oxygen preconditioning (HBO-PC) has been proposed as a safe and practical approach for neuroprotection in ischemic stroke. However, it is not known whether HPO-PC can improve cognitive deficits induced by cerebral ischemia, and the mechanistic basis for any beneficial effects remains unclear. We addressed this in the present study using rats subjected to middle cerebral artery occlusion (MCAO) as an ischemic stroke model following HBO-PC. Cognitive function and expression of phosphorylated neurofilament heavy polypeptide (pNF-H) and doublecortin (DCX) in the hippocampus were evaluated 14 days a...
Source: Physiological Research - September 22, 2017 Category: Physiology Authors: Ding P, Ren D, He S, He M, Zhang G, Chen Y, Sang H, Peng Z, Yan W Tags: Physiol Res Source Type: research

Hyperbaric oxygenation and 20 ‐HETE inhibition reduce stroke volume in female diabetic Sprague–Dawley rats
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Source: Experimental Physiology - September 1, 2017 Category: Physiology Authors: Mihael Mi šir, Marija Renić, Sanja Novak, Martina Mihalj, Anita Ćosić, Monika Vesel, Ines Drenjančević Tags: Research Paper Source Type: research

Breathing 100% oxygen during water immersion improves postimmersion cardiovascular responses to orthostatic stress
This study was conducted to compare hemodynamic responses to postural stress following exposure to WI alone (Air WI), hyperbaric oxygen alone in a hyperbaric chamber (O2 HC), and WI combined with hyperbaric oxygen (O2 WI), all at a depth of 1.35 ATA, and to determine whether hyperbaric oxygen is protective of orthostatic tolerance. Thirty‐two healthy men underwent up to 15 min of 70° head‐up tilt (HUT) testing before and after a single 6‐h resting exposure to Air WI (N = 10), O2 HC (N = 12), or O2 WI (N = 10). Heart rate (HR), blood pressure (BP), cardiac output (Q), stroke volume (SV), forearm blood flow (FB...
Source: Physiological Reports - December 15, 2016 Category: Physiology Authors: John P. Florian, Ki H. Chon, Luca Faes, Barbara E. Shykoff Tags: Original Research Source Type: research

Brain perfusion SPECT provides new insight on neurobiological effects of hyperbaric hyperoxia
This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - June 25, 2013 Category: Physiology Authors: Silvia Morbelli, Dario Arnaldi Tags: Editorial Source Type: research

Neurobiological insight into hyperbaric hyperoxia
ConclusionsThe present study firstly confirmed the rCBF distribution increase during HBO in sensory‐motor and visual cortices and it showed for the first time a higher perfusion tracer distribution in areas encompassed in dorsal attention system and in default mode network. These findings unfold both the externally directed cognition performance improvement related to the HBO and the internally directed cognition states during resting state conditions, suggesting possible beneficial effects in TBI and stroke patients.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - May 21, 2013 Category: Physiology Authors: Alessandro Micarelli, Hans Jacobsson, Stig A Larsson, Cathrine Jonsson, Marco Pagani Tags: Regular Paper Source Type: research