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Drug overdose and the risk of cardiovascular diseases: a nested case –control study
ConclusionsDrug overdose appears to be associated with increased risk of cardiovascular diseases.Graphic abstract
Source: Clinical Research in Cardiology - October 15, 2021 Category: Cardiology Source Type: research

Opioid Use and Its Relationship to Cardiovascular Disease and Brain Health: A Presidential Advisory From the American Heart Association
Circulation. 2021 Aug 19:CIR0000000000001007. doi: 10.1161/CIR.0000000000001007. Online ahead of print.ABSTRACTThe misuse of opioids continues to be epidemic, resulting in dependency and a recent upsurge in drug overdoses that have contributed to a significant decrease in life expectancy in the United States. Moreover, recent data suggest that commonly used opioids for the management of pain may produce undesirable pharmacological actions and interfere with critical medications commonly used in cardiovascular disease and stroke; however, the impact on outcomes remains controversial. The American Heart Association developed...
Source: Circulation - August 19, 2021 Category: Cardiology Authors: Sheryl L Chow Comilla Sasson Ivor J Benjamin Robert M Califf Wilson M Compton Elizabeth M Oliva Chester Robson Eduardo J Sanchez American Heart Association Source Type: research

Exosomes in atrial fibrillation: therapeutic potential and role as clinical biomarkers
AbstractAtrial fibrillation (AF), the most common cardiac arrhythmia, is a global epidemic. AF can cause heart failure and myocardial infarction and increase the risk of stroke, disability, and thromboembolic events. AF is becoming increasingly ubiquitous and is associated with increased morbidity and mortality at higher ages, resulting in an increasing threat to human health as well as substantial medical and social costs. Currently, treatment strategies for AF focus on controlling heart rate and rhythm with medications to restore and maintain sinus rhythm, but this approach has limitations. Catheter ablation is not entir...
Source: Heart Failure Reviews - July 12, 2021 Category: Cardiology Source Type: research

Anti-diabetic drugs for preventing atrial fibrillation: a new revolution?
Type 2 diabetes mellitus (DM) and atrial fibrillation (AF) are two of the great epidemics of our time. DM affects and estimated 8.5% of adults in the US1, and is associated with an increased risk of cardiovascular events, including AF.2 AF in turn affects an estimated up to 12.5% of adults over age 65 years in the US, decreases quality of life and increases the risks of heart failure, stroke and death 3,4. In 2015, the EMPA-REG OUTCOME randomized controlled trial (RCT), assessing a sodium glucose co-transporter 2 inhibitor (SGLT-2i), sparked interest in the therapeutic potential for oral anti-diabetic agents to reduce card...
Source: Heart Rhythm - April 7, 2021 Category: Cardiology Authors: William F. McIntyre, Jeff S. Healey Source Type: research

Antidiabetic drugs for preventing atrial fibrillation: A new revolution?
Type 2 diabetes mellitus (DM) and atrial fibrillation (AF) are 2 of the great epidemics of our time. DM affects an estimated 8.5% of adults in the United States1 and is associated with an increased risk of cardiovascular events, including AF.2 AF in turn affects up to an estimated 12.5% of adults older than 65 years in the United States, decreases quality of life, and increases the risks of heart failure, stroke, and death.3,4 In 2015, the EMPA-REG OUTCOME (BI 10773 [Empagliflozin] Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients) randomized controlled trial (RCT), which assessed the sodium glucose c...
Source: Heart Rhythm - April 7, 2021 Category: Cardiology Authors: William F. McIntyre, Jeff S. Healey Tags: Editorial Commentary Source Type: research

Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic?
Circ Res. 2021 Apr 2;128(7):908-933. doi: 10.1161/CIRCRESAHA.121.318052. Epub 2021 Apr 1.ABSTRACTElevated cardiovascular risk including stroke, heart failure, and heart attack is present even after normalization of blood pressure in patients with hypertension. Underlying immune cell activation is a likely culprit. Although immune cells are important for protection against invading pathogens, their chronic overactivation may lead to tissue damage and high blood pressure. Triggers that may initiate immune activation include viral infections, autoimmunity, and lifestyle factors such as excess dietary salt. These conditions ac...
Source: Circulation Research - April 1, 2021 Category: Cardiology Authors: Meena S Madhur Fernando Elijovich Matthew R Alexander Ashley Pitzer Jeanne Ishimwe Justin P Van Beusecum David M Patrick Charles D Smart Thomas R Kleyman Justin Kingery Robert N Peck Cheryl L Laffer Annet Kirabo Source Type: research

Bending the Curve in Cardiovascular Disease Mortality: Bethesda + 40 and Beyond
This report summarizes the relevant research, policy, and practice opportunities discussed at the symposium.PMID:33617315 | DOI:10.1161/CIRCULATIONAHA.120.046501
Source: Circulation - February 22, 2021 Category: Cardiology Authors: David Calvin Goff Sadiya Sana Khan Donald Lloyd-Jones Donna K Arnett Mercedes R Carnethon Darwin R Labarthe Matthew Shane Loop Russell V Luepker Michael V McConnell George A Mensah Mahasin S Mujahid Martin Enrique O'Flaherty Dorairaj Prabhakaran V éroniq Source Type: research

Comparison of Frequency of Atrial Fibrillation in Blacks versus Whites and the Utilization of Race in a Novel Risk Score
Atrial fibrillation (AF) is the most prevalent sustained arrhythmia in the world, with over 30 million people affected as of 2010.1 The number of patients projected to develop AF will double over the next decade.2 AF is independently associated with an increased risk of stroke,3 heart failure (HF),4 and mortality.5 It is not surprising, thus, that AF assumes a sizeable share of health care expenditure and its magnitude is reaching epidemic proportions.6 Blacks despite having a higher prevalence of traditional risk factors for AF, such as HF, hypertension, and diabetes mellitus, have been shown to have a lower incidence of AF.
Source: The American Journal of Cardiology - August 27, 2020 Category: Cardiology Authors: Gurukripa N. Kowlgi, Sampath Gunda, Santosh K. Padala, Jayanthi N. Koneru, Abhishek J. Deshmukh, Kenneth A. Ellenbogen Source Type: research

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