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Specialty: Cardiology
Condition: Heart Attack
Drug: Insulin
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Total 78 results found since Jan 2013.
Steady solution and its stability of a mathematical model of diabetic atherosclerosis
J Biol Dyn. 2023 Dec;17(1):2257734. doi: 10.1080/17513758.2023.2257734.ABSTRACTAtherosclerosis is a leading cause of death worldwide. Making matters worse, nearly 463 million people have diabetes, which increases atherosclerosis-related inflammation. Diabetic patients are twice as likely to have a heart attack or stroke. In this paper, we consider a simplified mathematical model for diabetic atherosclerosis involving LDL, HDL, glucose, insulin, free radicals (ROS), β cells, macrophages and foam cells, which satisfy a system of partial differential equations with a free boundary, the interface between the blood flow and th...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Xuming Xie Source Type: research
Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland
Conclusions: Patients diagnosed with NFAIs, despite normal cortisol inhibition in the 1 mg dexamethasone test, still presented a number of metabolic abnormalities. The assessment of IMT may proove valuable in indicate the presence of early vascular remodelling in asymptomatic patients. The underlying mechanisms of these findings are still unknown, hence further studies are required.PMID:37510727 | PMC:PMC10380859 | DOI:10.3390/jcm12144612
Source: Atherosclerosis - July 29, 2023 Category: Cardiology Authors: Magdalena Szychli ńska Magdalena Rzeczkowska Katarzyna Gontarz-Nowak Wojciech Matuszewski El żbieta Bandurska-Stankiewicz Source Type: research
New insights on the cardiovascular effects of IGF-1
DISCUSSION: We anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.PMID:36843588 | PMC:PMC9947133 | DOI:10.3389/fendo.2023.1142644
Source: Atherosclerosis - February 27, 2023 Category: Cardiology Authors: Mirjana Macvanin Zoran Gluvic Jelena Radovanovic Magbubah Essack Xin Gao Esma R Isenovic Source Type: research
How dysregulation of the immune system promotes diabetes mellitus and cardiovascular risk complications
Front Cardiovasc Med. 2022 Sep 29;9:991716. doi: 10.3389/fcvm.2022.991716. eCollection 2022.ABSTRACTDiabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin resistance or failure to produce insulin. Patients with DM develop microvascular complications that include chronic kidney disease and retinopathy, and macrovascular complications that mainly consist in an accelerated and more severe atherosclerosis compared to the general population, increasing the risk of cardiovascular (CV) events, such as stroke or myocardial infarction by 2- to 4-fold. DM is commonly associate...
Source: Atherosclerosis - October 17, 2022 Category: Cardiology Authors: Diane Girard Claire Vandiedonck Source Type: research
Well-posedness of a mathematical model of diabetic atherosclerosis with advanced glycation end-products
Appl Anal. 2022;101(11):3989-4013. doi: 10.1080/00036811.2022.2060210. Epub 2022 Apr 6.ABSTRACTAtherosclerosis is a leading cause of death worldwide; it emerges as a result of multiple dynamical cell processes including hemodynamics, endothelial damage, innate immunity and sterol biochemistry. Making matters worse, nearly 463 million people have diabetes, which increases atherosclerosis-related inflammation, diabetic patients are twice as likely to have a heart attack or stroke. The pathophysiology of diabetic vascular disease is generally understood. Dyslipidemia with increased levels of atherogenic LDL, hyperglycemia, ox...
Source: Atherosclerosis - October 3, 2022 Category: Cardiology Authors: Xuming Xie Source Type: research
Heterogeneity of outcomes within diabetic patients with atrial fibrillation on edoxaban: a sub-analysis from the ETNA-AF Europe registry
ConclusionsIn a real-world cohort of AF patients on edoxaban, diabetes requiring insulin therapy, rather than the presence of diabetes per se, appears to be an independent factor affecting the occurrence of thromboembolic events during follow-up. Regardless of the diabetes type, diabetic patients had a lower survival compared with those without diabetes.Graphical abstract
Source: Clinical Research in Cardiology - August 17, 2022 Category: Cardiology Source Type: research
Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study
CONCLUSIONS: In this large, community-based cohort, higher meat intake associated with incident ASCVD, partly mediated by microbiota-derived metabolites of L-carnitine, abundant in red meat. These novel findings support biochemical links between dietary meat, gut microbiome pathways, and ASCVD.PMID:35912635 | DOI:10.1161/ATVBAHA.121.316533
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 1, 2022 Category: Cardiology Authors: Meng Wang Zeneng Wang Yujin Lee Heidi T M Lai Marcia C de Oliveira Otto Rozenn N Lemaitre Amanda Fretts Nona Sotoodehnia Matthew Budoff Joseph A DiDonato Barbara McKnight W H Wilson Tang Bruce M Psaty David S Siscovick Stanley L Hazen Dariush Mozaffarian Source Type: research
Causal Association of Type 2 Diabetes Mellitus and Glycemic Traits With Cardiovascular Diseases and Lipid Traits: A Mendelian Randomization Study
CONCLUSION: We provided evidence for the causal effects of T2DM and glycemic traits on the risk of CVDs and dyslipidemia. Further investigations to elucidate the underlying mechanisms are warranted.PMID:35528012 | PMC:PMC9072667 | DOI:10.3389/fendo.2022.840579
Source: Atherosclerosis - May 9, 2022 Category: Cardiology Authors: Mingkai Huang Loum-Davadi Laina-Nicaise Lingfeng Zha Tingting Tang Xiang Cheng Source Type: research
Heart health in polycystic ovary syndrome: time to act on the data
Fertil Steril. 2022 May;117(5):885-886. doi: 10.1016/j.fertnstert.2022.03.014.ABSTRACTPolycystic ovary syndrome (PCOS), first described over 80 years ago, is a chronic condition with gynecologic, metabolic, and psychologic manifestations. Both hyperandrogenism and insulin resistance are associated with the high prevalence of cardiometabolic risk factors described in this population. Although robust data in reproductive-age women demonstrate a high rate of obesity, impaired glucose tolerance, hypertension, dyslipidemia, and metabolic syndrome, studies show mixed results in the adolescent and menopausal age groups. There is ...
Source: Atherosclerosis - May 5, 2022 Category: Cardiology Authors: Anuja Dokras Source Type: research
