Filtered By:
Specialty: Physiology
Condition: Ischemic Stroke

This page shows you your search results in order of date.

Order by Relevance | Date

Total 313 results found since Jan 2013.

Astrocytes in functional recovery following central nervous system injuries
J Physiol. 2023 Sep 13. doi: 10.1113/JP284197. Online ahead of print.ABSTRACTAstrocytes are increasingly recognised as partaking in complex homeostatic mechanisms critical for regulating neuronal plasticity following central nervous system (CNS) insults. Ischaemic stroke and traumatic brain injury are associated with high rates of disability and mortality. Depending on the context and type of injury, reactive astrocytes respond with diverse morphological, proliferative and functional changes collectively known as astrogliosis, which results in both pathogenic and protective effects. There is a large body of research on the...
Source: The Journal of Physiology - September 13, 2023 Category: Physiology Authors: Qasim M Alhadidi Ghaith A Bahader Oiva Arvola Philip Kitchen Zahoor A Shah Mootaz M Salman Source Type: research

Differential effect of gold nanoparticles on cerebrovascular function and biomechanical properties
This study provides the first evidence that GNPs affect the structure and function of the cerebrovasculature, which may be important for their development and use in biomedical applications.
Source: Physiological Reports - August 22, 2023 Category: Physiology Authors: Ryan D. Hunt, Omid Sedighi, Wayne M. Clark, Amber L. Doiron, Marilyn  J. Cipolla Tags: ORIGINAL ARTICLE Source Type: research

Sitagliptin therapy improves myocardial perfusion and arteriolar collateralization in chronically ischemic myocardium: A pilot study
In conclusion, in chronically ischemic myocardium, sitagliptin improves myocardial perfusion and arteriolar collateralization via the activation of pro-arteriogenic signaling pathways.
Source: Physiological Reports - June 11, 2023 Category: Physiology Authors: Sharif A. Sabe, Dwight Douglas Harris, Mark Broadwin, Mohamed Sabra, Cynthia M. Xu, Debolina Banerjee, M. Ruhul Abid, Frank W. Sellke Tags: ORIGINAL ARTICLE Source Type: research

Perlecan: A Review of its Role in Neurologic and Musculoskeletal Disease
Perlecan is a 500 kDa proteoglycan residing in the extracellular matrix of endothelial basement membranes with five distinct protein domains and three heparan sulfate chains. The complex structure of perlecan and the interaction it has with its local environment accounts for its various cellular and tissue-related effects, to include cartilage, bone, neural and cardiac development, angiogenesis, and blood brain barrier stability. As perlecan is a key contributor to extracellular matrix health involved in many tissues and processes throughout the body, dysregulation of perlecan has the potential to contribute to various neu...
Source: Frontiers in Physiology - May 30, 2023 Category: Physiology Source Type: research

Investigating spatial variations in dynamic cerebral autoregulation through a computational model of stenosis
Objective. Dynamic cerebral autoregulation (dCA) is a well-established mechanism that acts to maintain cerebral blood flow (CBF) reasonably constant in response to short-term fluctuations in blood pressure. It is known to be impaired in many clinical conditions, including stenosis, which is also a major risk factor for ischaemic stroke. However, it is not yet well understood whether impairment in dCA in one brain region is independent or not on dCA impairment in other brain regions, for example, whether there are spatial effects of stenosis on dCA. This is due to the complex blood flow environment and the lack of physiolog...
Source: Physiological Measurement - April 18, 2023 Category: Physiology Authors: Zheng Tong and Stephen J Payne Source Type: research

Concurrent validity of machine learning-classified functional upper extremity use from accelerometry in chronic stroke
Conclusion: Our machine learning approach provides a valid measure of functional UE use. The accuracy, validity, and small footprint of this machine learning approach makes it feasible for measurement of UE recovery in stroke rehabilitation trials.
Source: Frontiers in Physiology - March 22, 2023 Category: Physiology Source Type: research

Repair of traumatic lesions to the plasmalemma of neurons and other cells: Commonalities, conflicts, and controversies
We describe current research gaps and potential future developments, such as much more extensive correlations of biochemical/biophysical measures with sub-cellular micromorphology. We compare and contrast naturally occurring sealing with recently-discovered artificially-induced plasmalemmal sealing by polyethylene glycol (PEG) that bypasses all natural pathways for membrane repair. We assess other recent developments such as adaptive membrane responses in neighboring cells following injury to an adjacent cell. Finally, we speculate how a better understanding of the mechanisms involved in natural and artificial plasmalemmal...
Source: Frontiers in Physiology - March 15, 2023 Category: Physiology Source Type: research

Sex Differences in Cardiovascular Disease and Dysregulation in Down Syndrome
Am J Physiol Heart Circ Physiol. 2023 Feb 17. doi: 10.1152/ajpheart.00544.2022. Online ahead of print.ABSTRACTThis scoping review and retrospective medical record review is focused on potential sex differences in cardiovascular diseases in patients with Down syndrome. We limited our review to peer-reviewed, primary articles in the English language, in the PubMed and Web of Science databases from 1965-2021. Four categorical domains were identified and searched using additional keywords: 1) congenital heart disease, 2) baseline physiology and risk factors, 3) heart disease and hypertension, and 4) stroke and cerebrovascular ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 17, 2023 Category: Physiology Authors: Melissa L Bates Anastasiia Vasileva Laura D M Flores Yana Pryakhina Michelle Buckman Michael H Tomasson Lara R DeRuisseau Source Type: research

Embolic occlusion of internal carotid artery in conscious rats: Immediate effects of cerebral ischemia
In a refinement of the embolic clot stroke model, injection of different length blood clots into the internal carotid artery of unanesthetized rats produced graded increases in arterial blood pressure, brain water content, neurological deficits, and infarct volume. The increase in arterial pressure correlated with the eventual volume of infarcted brain tissue. AbstractIn most preclinical models of focal ischemic stroke, vascular occlusion is performed under general anesthesia. However, anesthetic agents exert confounding effects on mean arterial blood pressure (MABP), cerebrovascular tone, oxygen demand, and neurotransmitt...
Source: Physiological Reports - February 17, 2023 Category: Physiology Authors: Thomas J. K. Toung, Noah Mehr, Marek Mirski, Raymond C. Koehler Tags: ORIGINAL ARTICLE Source Type: research