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The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions
AbstractThe molecular mechanisms of angiogenesis have been intensely studied, but many genes that control endothelial behavior and fate still need to be described. Here, we characterize the role ofApold1 (Apolipoprotein L domain containing 1) in angiogenesis in vivo and in vitro. Single-cell analyses reveal that - across tissues - the expression ofApold1 is restricted to the vasculature and thatApold1 expression in endothelial cells (ECs) is highly sensitive to environmental factors. UsingApold1−/− mice, we find thatApold1 is dispensable for development and does not affect postnatal retinal angiogenesis nor alters the ...
Source: Angiogenesis - March 18, 2023 Category: Molecular Biology Source Type: research

Elevated TGF β Signaling Contributes to Cerebral Small Vessel Disease in Mouse Models of Gould Syndrome
CONCLUSIONS: This study identifies a novel biological role for collagen α1α1α2(IV) as a regulator of TGFβ signaling and demonstrates that elevated TGFβ signaling contributes to CNS vascular pathologies caused by Col4a1 mutations. Our findings suggest that pharmacologically suppressing TGFβ signaling could reduce the severity of CSVD, and potentially other manifestations associated with Gould syndrome and have important translational implications that could extend to idiopathic forms of CSVD.PMID:36435425 | DOI:10.1016/j.matbio.2022.11.007
Source: Matrix Biology - November 26, 2022 Category: Molecular Biology Authors: Kayla Branyan Cassandre Labelle-Dumais Xiaowei Wang Genki Hayashi Bryson Lee Zoe Peltz Se án Gorman Bo Qiao Li Mao Mao Douglas B Gould Source Type: research

Retina as a window to cerebral dysfunction following studies with circRNA signature during neurodegeneration
Conclusions: This study provides molecular evidence that the retina is window of the brain from circRNA perspective. cGLIS3 is a common regulator and diagnostic marker of cerebral neurodegeneration and retinal neurodegeneration.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Qin Jiang, Dong-Yuan Su, Zhen-Zhen Wang, Chang Liu, Ya-Nan Sun, Hong Cheng, Xiu-Miao Li, Biao Yan Tags: Research Paper Source Type: research

Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection
We present an overview of how a) NPD1 selectively mediates preconditioning rescue of RPE and PR cells; b) NPD1 restores aberrant neuronal networks in experimental epileptogenesis; c) the decreased ability to biosynthesize NPD1 in memory hippocampal areas of early stages of Alzheimer's disease takes place; d) NPD1 protection of dopaminergic circuits in an in vitro model using neurotoxins; and e) bioactivity elicited by DHA and NPD1 activate a neuroprotective gene-expression program that includes the expression of Bcl-2 family members affected by Aβ42, DHA, or NPD1. In addition, we highlight ELOVL4 (ELOngation of Very Long ...
Source: Molecular Aspects of Medicine - October 5, 2018 Category: Molecular Biology Source Type: research