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Molecular explanation of Wnt/ βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders
Mol Biol Rep. 2022 Sep 15. doi: 10.1007/s11033-022-07863-7. Online ahead of print.ABSTRACTThe symptoms of ageing are somewhat different and can lead to the altered role of the cardiovascular system at the levels of genetic, biochemical, tissue, organ, and systems. Ageing is an autonomous cardiovascular risk factor. In the ageing rat heart, oxidative and inflammatory stress, immune cell infiltration, increasing myeloperoxidase function, elevated caspase-3 activity, and protein fibronectins were detected and associated with ageing and cardiovascular disease. The intracellular Ca2 + homeostasis disturbed in an older heart dra...
Source: Molecular Biology Reports - September 15, 2022 Category: Molecular Biology Authors: Khalid Saad Alharbi Yogendra Singh Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Imran Kazmi Fahad A Al-Abbasi Sami I Alzarea Dinesh Kumar Chellappan Sachin Kumar Singh Kamal Dua Gaurav Gupta Source Type: research

Preserving mitochondrial function by inhibiting GRP75 ameliorates neuron injury under ischemic stroke
Mol Med Rep. 2022 May;25(5):165. doi: 10.3892/mmr.2022.12681. Epub 2022 Mar 16.ABSTRACTIschemic stroke is a life‑threatening disease, which is closely related to neuron damage during ischemia. Mitochondrial dysfunction is essentially involved in the pathophysiological process of ischemic stroke. Mitochondrial calcium overload contributes to the development of mitochondrial dysfunction. However, the underlying mechanisms of mitochondrial calcium overload are far from being fully revealed. In the present study, middle cerebral artery obstruction (MCAO) was performed in vivo and oxygen and glucose deprivation (OGD) in vitro...
Source: Molecular Medicine - March 16, 2022 Category: Molecular Biology Authors: Bin Wen Kai Xu Rui Huang Teng Jiang Jian Wang Jiehui Chen Juan Chen Benhong He Source Type: research

Role of Na < sup > + < /sup > /K < sup > + < /sup > -ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology
J Mol Med (Berl). 2021 Nov 27. doi: 10.1007/s00109-021-02143-6. Online ahead of print.ABSTRACTNa+/K+-ATPase (NKA) is a large transmembrane protein expressed in all cells. It is well studied for its ion exchanging function, which is indispensable for the maintenance of electrochemical gradients across the plasma membrane and herein neuronal excitability. The widely recognized pump function of NKA closely depends on its unique structure features and conformational changes upon binding of specific ions. Various Na+-dependent secondary transport systems are rigorously controlled by the ionic gradients generated by NKA and are ...
Source: Molecular Medicine - November 28, 2021 Category: Molecular Biology Authors: Mengyuan Zhu Haijian Sun Lei Cao Zhiyuan Wu Bin Leng Jinsong Bian Source Type: research

Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology
AbstractNa+/K+-ATPase (NKA) is a large transmembrane protein expressed in all cells. It is well studied for its ion exchanging function, which is indispensable for the maintenance of electrochemical gradients across the plasma membrane and herein neuronal excitability. The widely recognized pump function of NKA closely depends on its unique structure features and conformational changes upon binding of specific ions. Various Na+-dependent secondary transport systems are rigorously controlled by the ionic gradients generated by NKA and are essential for multiple physiological processes. In addition, roles of NKA as a signal ...
Source: Journal of Molecular Medicine - November 27, 2021 Category: Molecular Biology Source Type: research

β2SP/TET2 complex regulates gene 5hmC modification after cerebral ischemia
J Cell Mol Med. 2021 Nov 19. doi: 10.1111/jcmm.17060. Online ahead of print.ABSTRACTβII spectrin (β2SP) is encoded by Sptbn1 and is involved in the regulation of various cell functions. β2SP contributes to the formation of the myelin sheath, which may be related to the mechanism of neuropathy caused by demyelination. As one of the main features of cerebral ischemia, demyelination plays a key role in the mechanism of cerebral ischemia injury. Here, we showed that β2SP levels were increased, and this molecule interacted with TET2 after ischemic injury. Furthermore, we found that the level of TET2 was decreased in the nuc...
Source: J Cell Mol Med - November 20, 2021 Category: Molecular Biology Authors: Xiaohua Ma Meng Zhang Rui Yan Hainan Wu Bo Yang Zhigang Miao Source Type: research

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