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Specialty: Biology
Condition: Ischemic Stroke
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Total 194 results found since Jan 2013.
Computational modeling of multiscale collateral blood supply in a whole-brain-scale arterial network
In this study, a computational model of multiscale anastomoses in whole-brain-scale cerebral arterial networks was developed and used to evaluate collateral blood supply by anastomoses during middle cereb ral artery occlusion. Morphologically validated cerebral arterial networks were constructed by combining medical imaging data and mathematical modeling. Sparse intermediate anastomoses were assigned between adjacent main arterial branches; the pial arterial network was modeled as a dense network str ucture. Blood flow distributions in the arterial network during middle cerebral artery occlusion simulations were computed. ...
Source: PLoS Computational Biology - September 8, 2023 Category: Biology Authors: Tomohiro Otani Source Type: research
Overexpression of Circ_0005585 Alleviates Cerebral Ischemia Reperfusion Injury via Targeting MiR-16-5p
Circular RNAs are implicated in the pathogenesis of ischemic stroke. In this work, we explored the modulation and potential mechanisms of action of circ_0005585 in ischemic stroke. Expression of circ_0005585 and miR-16-5p was assessed by quantitative real-time reverse transcription PCR. Ischemic stroke was modeled in mice by middle cerebral artery occlusion (MCAO). The infarct volume was assessed by triphenyl tetrazolium chloride staining. Neurological deficits were evaluated according to Neurological Severity Score. The permeability of the blood —brain barrier was assessed by Evan’s blue leakage and brain water conten...
Source: Bulletin of Experimental Biology and Medicine - August 11, 2023 Category: Biology Source Type: research
Hyperglycemia exacerbates ischemic stroke not through increased generation of hydrogen peroxide
Free Radic Biol Med. 2023 Aug 3:S0891-5849(23)00576-2. doi: 10.1016/j.freeradbiomed.2023.08.004. Online ahead of print.ABSTRACTDiabetes is one of the significant risk factors for ischemic stroke. Hyperglycemia exacerbates the pathogenesis of stroke, leading to more extensive cerebral damage and, as a result, to more severe consequences. However, the mechanism whereby the hyperglycemic status in diabetes affects biochemical processes during the development of ischemic injury is still not fully understood. In the present work, we record for the first time the real-time dynamics of H2O2 in the matrix of neuronal mitochondria ...
Source: Free Radical Biology and Medicine - August 5, 2023 Category: Biology Authors: Daria A Kotova Alexandra D Ivanova Matvei S Pochechuev Ilya V Kelmanson Yulia V Khramova Alisa Tiaglik Mark A Sudoplatov Arina P Trifonova Anna Fedotova Kseniia Morozova Veronika A Katrukha Anastasia D Sergeeva Roman I Raevskii Mariia P Pestriakova Maxim Source Type: research
Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization
by Pinyi Liu, Yan Chen, Zhi Zhang, Zengqiang Yuan, Jian-Guang Sun, Shengnan Xia, Xiang Cao, Jian Chen, Cun-Jin Zhang, Yanting Chen, Hui Zhan, Yuexinzi Jin, Xinyu Bao, Yue Gu, Meijuan Zhang, Yun Xu
Microglia-mediated neuroinflammation is involved in various neurological diseases, including ischemic stroke, but the endogenous mechanisms preventing unstrained inflammation is still unclear. The anti-inflammatory role of transcription factor nuclear receptor subfamily 4 group A member 1 (NR4A1) in macrophages and microglia has previously been identified. However, the endogenous mechanisms that how NR4A1 restricts unstrained in...
Source: PLoS Biology: Archived Table of Contents - July 24, 2023 Category: Biology Authors: Pinyi Liu Source Type: research
Lithium Co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3 β activity in a rat model
Free Radic Biol Med. 2023 Jul 4:S0891-5849(23)00522-1. doi: 10.1016/j.freeradbiomed.2023.07.004. Online ahead of print.ABSTRACTCerebral ischemic stroke is one of the leading causes of adult disability worldwide. Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we investigated the efficacy of rutin and lithium co-treatment in improving post-stroke neurological outcomes in a transient global cerebral ischemia-reperfusion injury rat model. Middle-aged male rats were subjected to transient global cerebral ischemia-reperfusion. NORT and Y-maze were used to assess the cognitive process...
Source: Free Radical Biology and Medicine - July 6, 2023 Category: Biology Authors: Anil Kumar Rana Rajneesh Kumar Durgesh Nandan Shukla Damanpreet Singh Source Type: research
Therapeutic Efficacy and Migration of Mesenchymal Stem Cells after Intracerebral Transplantation in Rats with Experimental Ischemic Stroke
We studied therapeutic efficacy and migration characteristics of mesenchymal stem cells isolated from the human placenta after their intracerebral (stereotactic) administration to rats with the experimental ischemic stroke. It was shown that cell therapy significantly improved animal survival rate and reduced the severity of neurological deficit. New data on the migration pathways of transplanted cells in the brain were obtained.
Source: Bulletin of Experimental Biology and Medicine - June 19, 2023 Category: Biology Source Type: research
Identification of three potential novel biomarkers for early diagnosis of acute ischemic stroke via plasma lipidomics
ConclusionsOur work provides valuable information on the pathophysiology of AIS and constitutes an important step toward clinical application of blood-based biomarkers for diagnosing AIS.
Source: Metabolomics - March 30, 2023 Category: Biology Source Type: research
Nootropic Activity of Prospekta in a Blind Placebo-Controlled Study in a Model of Focal Cerebral Ischemia in Rats
Analysis of the pharmacological activity of the original drug Prospekta in a rat model of focal cerebral ischemia revealed its nootropic effect: course treatment in the post-ischemic period led to recovery of the neurological status of animals at the peak of neurological deficit. Evaluation of the therapeutic potential of the drug in morphological and functional CNS disorders allowed us to conclude that it is advisable to carry out further studies of its biological activity at the preclinical stage (the results obtained in animals were successfully confirmed in a clinical trial of drug efficacy in the treatment of moderate...
Source: Bulletin of Experimental Biology and Medicine - March 9, 2023 Category: Biology Source Type: research
Altered trafficking of miRNAs at mitochondria modulates mitochondrial functions and cell death in brain ischemia
Free Radic Biol Med. 2023 Feb 11:S0891-5849(23)00053-9. doi: 10.1016/j.freeradbiomed.2023.02.004. Online ahead of print.ABSTRACTStroke is one of the major causes of death and disabilities worldwide. The rapid induction of cell death by necrosis and apoptosis is observed at the ischemic core, while long lasting apoptosis and brain inflammation continue in the penumbra. The emerging evidence suggests a critical role of mitochondria in acute and chronic inflammation and cell death. Mitochondrial dysfunction may result in the release of mitokines and/or mitochondrial DNA into the cytoplasm and activate multiple cytosolic pathw...
Source: Free Radical Biology and Medicine - February 13, 2023 Category: Biology Authors: Dhruv Gohel Shatakshi Shukla Wenson David Rajan Bartosz Wojtas Bozena Kaminska Rajesh Singh Source Type: research
