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Specialty: Biomedical Science
Countries: Japan Health

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Total 28 results found since Jan 2013.

Vascular endothelial growth factor receptor 1 gene ( < em > FLT1 < /em > ) longevity variant increases lifespan by reducing mortality risk posed by hypertension
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.PMID:37178326 | DOI:10.18632/aging.204722
Source: Aging - May 13, 2023 Category: Biomedical Science Authors: Brian J Morris Randi Chen Timothy A Donlon Kalpana J Kallianpur Kamal H Masaki Bradley J Willcox Source Type: research

Reduction in medical costs for cardiovascular diseases through innovative health awareness projects in a rural area in Japan
by Ayako Shoji, Kennichi Kudo, Koichi Murashita, Shigeyuki Nakaji, Ataru Igarashi To promote health awareness and improve life expectancy in Hirosaki, a Japanese rural area, the Center of Healthy Aging Program (CHAP) was founded in 2013. The most important characteristic of CHAP is a personalized interview just after the checkup to discuss individual results. We evaluated the c linical and economic effects of CHAP by analyzing the cohort data of voluntary participants from annual health checkups since 2005 in the Iwaki district of Hirosaki. We calculated 10-year incidence risk scores for coronary heart diseases (CHDs) and...
Source: PLoS One - November 16, 2022 Category: Biomedical Science Authors: Ayako Shoji Source Type: research

Comparison of short-term clinical outcomes between low-dose prasugrel and clopidogrel as part of triple antithrombotic therapy in patients requiring oral anticoagulant therapy and percutaneous coronary intervention
ConclusionsCombination of low-dose prasugrel and DOAC was associated with lower incidence of MI, ischemic stroke, and blood transfusion. Low-dose prasugrel may be feasible as part of triple therapy in patients undergoing PCI.
Source: PLoS One - July 28, 2022 Category: Biomedical Science Authors: Hideki Kitahara Source Type: research

Association of C-reactive Protein with Cardiovascular Outcomes: A Mendelian Randomization Study in the Japanese Population
CONCLUSIONS: Suggestive evidence was found only in analysis of congestive heart failure; therefore, further studies are necessary. Furthermore, no causal association was found between CRP and the other three cardiovascular outcomes.PMID:35197177 | DOI:10.3967/bes2022.017
Source: Biomedical and Environmental Sciences : BES - February 24, 2022 Category: Biomedical Science Authors: Ming Yang Cao Di Liu Xiao Yu Zhang Qiu Yue Tian Qun Zhang You Xin Wang Source Type: research