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Association of Angiotensin II Type 1 Receptor (AT1R) Gene Polymorphism with Angiotensin II Serum Levels in Patients with Essential Hypertension
This study aimed to determine genotype and allele frequencies of A1166C polymorphism of AT1R gene in Indian patients with EH and correlated with serum levels of Angiotensin II. A total of 200 patients with EH and 200 age- and gender-matched control individuals were included in this study from the General Medicine Department Outpatient at Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India. Patients with systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg were considered as hypertensive. The findings of this study revealed significantly increased risk of C/A heteroz...
Source: Clinical Biochemistry - January 23, 2023 Category: Biochemistry Authors: M Prasad D Rajarajeswari K Ramlingam R Viswakumar B Suneel Jyothi Conjeevaram P Aruna Nusrath Fathima Sandeep Kumar Vishwakarma Aleem Ahmed Khan Source Type: research

Role of Brain Biomarker in Predicting Clinical Outcome in Hypertensive Cerebrovascular Ischemic Stroke
This study was undertaken to evaluate the role of serum neuron specific enolase (NSE) in prediction of disability and neurological worsening in hypertensive ischemic cerebrovascular stroke. 80 hypertensive ischemic stroke patients diagnosed by a neurologist as per WHO definition along with radiological findings suggestive of cerebrovascular stroke and differentiating from hemorrhagic stroke and 60 controls having essential hypertension coming to hospital because of regular checkup or headache but with no neurological disease were included in the study. Neurological disability was assessed by NIHSS at the time of admission ...
Source: Indian Journal of Clinical Biochemistry - April 1, 2018 Category: Biochemistry Source Type: research

Correlation of Serum Nitric Oxide (NO) with Glasgow Coma Scale (GCS) in Acute Ischemic Stroke Patient: A Study in North India
AbstractNitric oxide (NO) is one of the key players in the pathogenesis of ischemic stroke. Limited reports are available about the serum level of NO and their correlation with Glasgow Coma Scale (GCS) score in acute (<24  h) ischemic stroke (AIS) patients. A hospital based, cross sectional study was done in North Indian population to find out correlation of serum NO and GCS in AIS patients. 50 patients of AIS and 25 healthy controls were chosen for the study. Serum NO level was measured by ELISA and GCS scores were assessed by a neurologist. Pearson correlation coefficients were analyzed to look for the relationship b...
Source: Indian Journal of Clinical Biochemistry - July 5, 2017 Category: Biochemistry Source Type: research

Blood ‐based protein biomarkers for stroke differentiation: A systematic review
Computed tomography (CT) scan is the mainstay for diagnosis of stroke; but the facility of CT scan is not easily available. A blood‐based biomarker approach is required to distinguish ischemic stroke (IS) from hemorrhagic stroke (HS) in pre‐hospital settings.To conduct a systematic review of diagnostic utility of blood biomarkers for differential diagnosis of stroke.A comprehensive literature search was carried out till March 7, 2017 in PubMed, Cochrane, Medline, OVID, and Google Scholar databases. Methodological quality of each study was assessed using the modified Quality Assessment of Diagnostic Accuracy Studies que...
Source: Proteomics. Clinical Applications - May 29, 2017 Category: Biochemistry Authors: Shubham Misra, Amit Kumar, Pradeep Kumar, Arun K Yadav, Dheeraj Mohania, Awadh K Pandit, Kameshwar Prasad, Deepti Vibha Tags: Review Source Type: research

Redox status in acute ischemic stroke: correlation with clinical outcome.
This study was aimed to assess redox state (through measurement of oxidative stress markers) of patients with acute ischemic stroke during different stages of follow-up period, and to find association between values of mentioned markers and clinical outcome. The investigation was conducted on 60 patients (both sexes, aged 75.90 ± 7.37 years) who were recruited in intensive care units at the Special Hospital for Cerebrovascular Diseases "Sveti Sava," Belgrade. After verification of AIS, patients were followed up in four interval of time: (1) at admission, (2) within 24 h after AIS, (3) within 72 h after AIS, and (4) 7...
Source: Molecular and Cellular Biochemistry - April 28, 2015 Category: Biochemistry Authors: Paspalj D, Nikic P, Savic M, Djuric D, Simanic I, Zivkovic V, Jeremic N, Srejovic I, Jakovljevic V Tags: Mol Cell Biochem Source Type: research

Admission clinical characteristics and early clinical outcomes among acute ischemic stroke patients
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Xin Gao , Jintao Zhang , Ying Peng , Huanqing Fan , Mei Chen , Tan Xu , Yonghong Zhang The purpose of the present study was to investigate the association between admission clinical characteristics and outcomes at discharge among acute ischemic stroke patients in the Chinese population. A total of 2,673 patients with acute ischemic stroke were included in the present study. The clinical characteristics at admission and other study variables were collected for all patients. The study outcome was defined as neurological deficien...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research