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Orexin-A alleviates astrocytic apoptosis and inflammation via Inhibiting OX1R-mediated NF- κB and MAPK signaling pathways in cerebral ischemia/reperfusion injury
Biochim Biophys Acta Mol Basis Dis. 2021 Aug 3:166230. doi: 10.1016/j.bbadis.2021.166230. Online ahead of print.ABSTRACTOrexin-A (OXA) is a neuropeptide with neuroprotective effect by reducing cerebral ischemia/reperfusion injury (CIRI). Inflammation and apoptosis mediated by astrocyte activation are the key pathological mechanisms for CIRI. We thus attempted to confirm neuroprotective effects of OXA on astrocytic inflammation and apoptosis in CIRI and clarify the relative mechanisms. A middle cerebral artery occlusion and reperfusion (MCAO/R) rat model and U251 glioma cells model subjected to oxygen glucose deprivation an...
Source: Biochimica et Biophysica Acta - August 6, 2021 Category: Biochemistry Authors: Dandan Xu Tingting Kong Ziqi Shao Minghui Liu Rumin Zhang Shengnan Zhang Qingxia Kong Jing Chen Baohua Cheng Chunmei Wang Source Type: research

Small Peptide and Protein-based Molecular Probes for Imaging Neurological Diseases.
Abstract Neurologic disorders are prevalent diseases in the population and represent a major cause of death and disability. Despite the advances made during recent decades, the early diagnosis of these diseases remains a challenge. Determining the pathophysiology of such disorders is also challenging and is a requirement for the development of new drugs and treatments. Molecular neuroimaging studies can help fill these gaps in knowledge by providing clinicians with the tools necessary to diagnose and monitor treatment response and by providing data to help researchers understand the mechanisms of disease. Molecula...
Source: Current Protein and Peptide Science - January 1, 2016 Category: Biochemistry Authors: Venturin GT, Cheng Z Tags: Curr Protein Pept Sci Source Type: research

Hypoxia-induced miR-497 decreases glioma cell sensitivity to TMZ by inhibiting apoptosis
Hypoxia is a common characteristic of rapidly growing tumors [1]. Hypoxic conditions induce many different types of physiological or pathophysiological responses, including high-altitude adaptation, stroke, wound healing, myocardial infarction, and cancer [2]. These changes are carefully controlled by a large number of hypoxia-inducible genes [2]. Among these genes, hypoxia-inducible factor 1α (HIF1α) is the key transcription factor induced by hypoxia, increasing the expression of many genes that are involved in metastasis, tumor recurrence, and angiogenesis [3–5].
Source: FEBS Letters - July 28, 2014 Category: Biochemistry Authors: Jin Lan, Yajun Xue, Huairui Chen, Sanhu Zhao, Zhijian Wu, Jun Fang, Cong Han, Meiqing Lou Source Type: research