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Real-world effectiveness of lipid-lowering medications on outcomes after stroke: potential implications of the new-user design
Introduction: Observational studies are increasingly being used to provide evidence on the real-world effectiveness of medications for preventing vascular diseases, such as stroke. We investigated whether the real-world effectiveness of treatment with lipid-lowering medications after ischemic stroke is affected by prevalent user bias. Methods: An observational cohort study of 90-day survivors of ischemic stroke, using person-level data from the Australian Stroke Clinical Registry (2012-2016; 45 hospitals) linked to administrative (pharmaceutical, hospital, death) records. Use of, and adherence to (proportion of days covered
Source: Neuroepidemiology - July 21, 2022 Category: Epidemiology Source Type: research

Impact of COVID-19 lockdowns on hospital presentations and admissions in the context of low community transmission: evidence from time series analysis in Melbourne, Australia
Conclusions Our analyses suggest citizens were willing and able to present with life-threatening conditions during Melbourne’s lockdowns, and that switching to telemedicine did not cause widespread spill-over from primary care into ED. During a pandemic, lockdowns may not inhibit appropriate hospital attendance where rates of infectious disease are low.
Source: Journal of Epidemiology and Community Health - March 10, 2022 Category: Epidemiology Authors: Collyer, T. A., Athanasopoulos, G., Srikanth, V., Tiruvoipati, R., Matthews, C., Mcinnes, N., Menon, S., Dowling, J., Braun, G., Krivitsky, T. A., Cooper, H., Andrew, N. E. Tags: COVID-19 Original research Source Type: research

Optimal measures for primary care physician encounters after stroke and association with survival: a data linkage study
Conclusions: Our persistence measure of regularity or composite measure may be useful when measuring physician encounters following stroke.
Source: Neuroepidemiology - December 22, 2021 Category: Epidemiology Source Type: research

A Multicentre Study Comparing Cerebrovascular Disease Profiles in Pacific Islander and Caucasian Populations Presenting with Stroke and Transient Ischaemic Attack
Conclusion: Distinct cerebrovascular disease profiles are identifiable in PI-born patients who present with TIA or stroke symptoms in Australia. These may be used in the future to direct targeted approaches to stroke prevention and care in culturally and linguistically diverse populations.Neuroepidemiology
Source: Neuroepidemiology - December 1, 2021 Category: Epidemiology Source Type: research

Feasibility of national living guideline methods: the Australian Stroke Guidelines
Key findingsIt is feasible to produce living evidence-based guidelines covering a wide range of topics related to management of stroke or transient ischaemic attack.What this adds to what is knownLiving evidence synthesis methods are becoming more common particularly in response to the COIVD-19 crisis. However, whether these methods can be applied to a large national guideline was unclear. This work shows that it is possible to develop rigorous living guidelines and update them by considering all major randomised trials and systematic reviews each month.
Source: Journal of Clinical Epidemiology - November 13, 2021 Category: Epidemiology Authors: Kelvin Hill, Coralie English, Bruce C.V. Campbell, Steve McDonald, Loyal Pattuwage, Peta Bates, Chris Lassig, Living Stroke Guidelines Executive Group and Content Development Group Source Type: research

Treatment with Multiple Therapeutic Classes of Medication is Associated with Survival after Stroke
Conclusion: Treatment with all three classes of guideline-recommended medications within 90 days post-discharge was associated with better survival. Ongoing efforts are required to ensure optimal pharmacological intervention for secondary prevention of stroke.
Source: Neuroepidemiology - November 10, 2021 Category: Epidemiology Source Type: research

Risk of Hemorrhagic Stroke in Patients Exposed to Nonsteroidal Anti-Inflammatory Drugs: A Meta-Analysis of Observational Studies
Conclusion: Our results indicated that the use of NSAIDs is significantly associated with a higher risk of developing hemorrhagic stroke. These results should be interpreted with caution because they may be confounded owing to the observational design of the individual studies. Nevertheless, we recommend that NSAIDs should be used judiciously, and their efficacy and safety should be monitored proactively.Neuroepidemiology 2018;51:166 –176
Source: Neuroepidemiology - September 2, 2018 Category: Epidemiology Source Type: research

Treatment and Outcomes of Working Aged Adults with Stroke: Results from a National Prospective Registry
Conclusions: Younger stroke patients exhibited distinct differences from their older counterparts with respect to demographic and clinical characteristics, prescription of antihypertensive medications and residual health status.Neuroepidemiology 2017;49:113 –120
Source: Neuroepidemiology - November 14, 2017 Category: Epidemiology Source Type: research