• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Safety and efficacy of recovery-promoting drugs for motor function after stroke: A systematic review of randomised controlled trials.
CONCLUSION: Candidate drug interventions promoting motor recovery post-stroke were identified, specifically selective serotonin reuptake inhibitors and levodopa; however, the high risk of bias in many trials is concerning. Drugs to improve motor function remain an important area of enquiry. Future research must focus on establishing the correct drug intervention to be administered at an optimal dose and time, combined with the most effective adjuvant physical therapy to drive stroke recovery. PMID: 30805655 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - February 27, 2019 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Combining Dopaminergic Facilitation with Robot-Assisted Upper Limb Therapy in Stroke Survivors: A Focused Review
ABSTRACT: Despite aggressive conventional therapy, lasting hemiplegia persists in a large percentage of stroke survivors. The aim of this article is to critically review the rationale behind targeting multiple sites along the motor learning network by combining robotic therapy with pharmacotherapy and virtual reality–based reward learning to alleviate upper extremity impairment in stroke survivors. Methods for personalizing pharmacologic facilitation to each individual’s unique biology are also reviewed. At the molecular level, treatment with levodopa was shown to induce long-term potentiation-like and practice-depende...
Source: American Journal of Physical Medicine and Rehabilitation - May 21, 2016 Category: Rehabilitation Tags: Literature Review Source Type: research

Neuropharmacology of Poststroke Motor and Speech Recovery
This article summarizes the published literature for pharmacologic agents used for the enhancement of motor and speech recovery after stroke. Amphetamine, levodopa, selective serotonin reuptake inhibitors, and piracetam were the most commonly used drugs. Pharmacologic augmentation of stroke motor and speech recovery seems promising but systematic, adequately powered, randomized, and double-blind clinical trials are needed. At this point, the use of these pharmacologic agents is not supported by class I evidence.
Source: Physical Medicine and Rehabilitation Clinics of North America - October 30, 2015 Category: Rehabilitation Authors: Zafer Keser, Gerard E. Francisco Source Type: research

Serotonin syndrome in stroke patients.
Conclusion: Because a considerable number of stroke patients have some limitation in communication, and serotonin syndrome is a potentially life-threatening condition, clinicians should pay particular attention to the potential for development of serotonin syndrome when prescribing these drugs to stroke patients. PMID: 25483226 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - December 12, 2014 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Role, indications and controversies of levodopa administration in chronic stroke patients.
Abstract Stroke leaves many patients disabled even after rehabilitative training, representing a major cause of disability. Several approaches to improve outcomes have been attempted in recent years, with only relative benefit. Emerging evidences show a potential role of pharmacological intervention to enhance motor recovery after stroke. Contrasting evidence are coming from experimental and clinical studies, so far, and pharmacological intervention during rehabilitation represents a major controversial in neurorehabilitation. Dopaminergic stimulation appears as one of the most promising way to improve motor recov...
Source: European Journal of Physical and Rehabilitation Medicine - April 5, 2013 Category: Rehabilitation Authors: Acler M, Manganotti P Tags: Eur J Phys Rehabil Med Source Type: research