Neuropharmacology of Poststroke Motor and Speech Recovery

This article summarizes the published literature for pharmacologic agents used for the enhancement of motor and speech recovery after stroke. Amphetamine, levodopa, selective serotonin reuptake inhibitors, and piracetam were the most commonly used drugs. Pharmacologic augmentation of stroke motor and speech recovery seems promising but systematic, adequately powered, randomized, and double-blind clinical trials are needed. At this point, the use of these pharmacologic agents is not supported by class I evidence.
Source: Physical Medicine and Rehabilitation Clinics of North America - Category: Rehabilitation Authors: Source Type: research

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Source: Headlines - Category: Radiology Source Type: news
Conditions:   Chronic Subdural Hematoma;   Anticoagulant-induced Bleeding;   Antithrombotic Drugs [Platelet-aggregation Inhibitors] Causing Adverse Effects in Therapeutic Use;   Thromboembolic Stroke;   Cardiovascular Stroke Intervention:   Procedure: CSDH evacuation Sponsor:   University Hospital of Ferrara Recruiting
Source: - Category: Research Source Type: clinical trials
OBJECTIVE: Previously it was found that balance self-efficacy mediated the relationship between physical capacity and participation after stroke. The effect of other factors that influence participation, such as depression, on this relationship has not bee...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Stumbling during gait is commonly encountered in patients who suffer from mild to serious walking problems, e.g., after stroke, in osteoarthritis, or amputees using a lower leg prosthesis. Instead of self-reporting, an objective assessment of the number of...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
Conclusion: MT performed on the SP angiosuite tended to prolong the time for guiding catheter placement. However, there was no difference in the overall procedure time, recanalization rate, or outcome between BP and SP angiosuites. Therefore, if the BP angiosuite is not available, the use of the SP angiosuite should be encouraged.Cerebrovasc Dis Extra 2021;11:112 –117
Source: Cerebrovascular Diseases Extra - Category: Neurology Source Type: research
J Rehabil Med. 2021 Oct 15. doi: 10.2340/jrm.v53.367. Online ahead of print.ABSTRACTOBJECTIVE: To investigate associations between pre-stroke physical activity and mobility, walking ability, and self-perceived upper extremity function during stroke unit care.DESIGN: A longitudinal, registry-based study with a consecutively collected cohort.SUBJECTS/PATIENTS: A total of 1,092 adults with stroke admitted to 3 Swedish stroke units between 2017 and 2018.METHODS: Logistic mixed effects regression models were performed to investigate associations (adjusted for age and sex). Pre-stroke physical activity was assessed with Saltin-G...
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Authors: Source Type: research
Am J Transl Res. 2021 Sep 15;13(9):10837-10842. eCollection 2021.ABSTRACTOBJECTIVE: To explore the clinical value of intermittent pneumatic compression (IPC) combined with an electric stimulator in the prevention of venous thromboembolism in stroke patients.METHODS: 58 stroke patients with hemiplegia admitted to the Department of Neurology in our hospital were recruited as the study cohort and randomly placed into a control group or an observation group, with 29 patients in each group. The control group was administered routine care and IPC, and the observation group was administered electric stimulation in addition to the...
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
CONCLUSION: The application of clinical nursing pathway can improve the disease cognition and quality of life of elderly patients with hypertension and cerebral infarction, and promote their recovery.PMID:34650739 | PMC:PMC8506990
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
J Sports Med Phys Fitness. 2021 Oct 15. doi: 10.23736/S0022-4707.21.12823-3. Online ahead of print.ABSTRACTBACKGROUND: Hypertension is highly prevalent in stroke patients and reducing blood pressure is a priority. Aerobic exercise is known to induce post-exercise hypotensive responses, but limited studies have documented this concept in stroke patients. The purpose was to investigate the effect of a single bout of moderate intensity continuous training (MICT) and high intensity interval training (HIIT) on post-exercise ambulatory blood pressure with patients with prior ischemic stroke or transient ischemic attack (TIA).MET...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Authors: Source Type: research
Conclusion: In ACCORD, the effect of BPv on adverse cardiovascular (but not cerebrovascular) outcomes is modified by baseline blood pressure and prior CVD. Recognizing these more nuanced relationships may help improve risk stratification and blood pressure management decisions as well as provide insight into potential underlying mechanisms.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Blood pressure measurement Source Type: research
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