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Specialty: Pediatrics
Source: The Journal of Pediatrics
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Total 44 results found since Jan 2013.
Left Ventricular Function and Dimensions Are Altered Early in Infants Developing Brain Injury in the Setting of Neonatal Encephalopathy
We evaluated the association between left cardiac three-dimensional echocardiographic parameters and brain injury in a single-center prospective study of neonates with neonatal encephalopathy. On day 2 of life, neonates with brain injury had higher left ventricle end-diastolic and stroke volume, but also higher peak global circumferential strain detected by 3D-echocardiogram.
Source: The Journal of Pediatrics - June 22, 2023 Category: Pediatrics Authors: Pierre Elias, Anie Lapointe, Pia Wintermark, Shiran Sara Moore, Daniela Villegas Martinez, Jessica Simoneau, Gabriel Altit Tags: Brief Reports Source Type: research
Pediatric stroke codes need to grow up
Previously in The Journal, Harrar et al (J Pediatr 2020;216:136-41.e6. DOI: https://doi.org/10.1016/j.jpeds.2019.09.027) reported that the use of a pediatric stroke code system could decrease median time to just over an hour from emergency department arrival to neuroimaging. Timely diagnosis is prerequisite in order to initiate interventional therapies quickly and improve neurologic outcomes. Time is brain! However, this prior study analyzed data from only one advanced, tertiary children's hospital.
Source: The Journal of Pediatrics - February 22, 2022 Category: Pediatrics Authors: Paul G. Fisher Tags: The Editors' Perspectives Source Type: research
Pediatric Acute Stroke Protocols in the United States and Canada
To describe existing pediatric acute stroke protocols to understand better how pediatric centers might implement such pathways within the context of institution-specific structures.
Source: The Journal of Pediatrics - November 10, 2021 Category: Pediatrics Authors: Dana B. Harrar, Giulia M. Benedetti, Anuj Jayakar, Jessica L. Carpenter, Tara K. Mangum, Melissa Chung, Brian Appavu, International Pediatric Stroke Study Group, Pediatric Neurocritical Care Research Group Tags: Original Articles Source Type: research
Birth weight as destiny?
In 1989, Barker et al reported a correlation between lower birth weights and increased risk for death in adulthood from ischemic heart disease in men born between 1911-1930 in England (Lancet 1989;2:577-80. doi: https://doi.org/10.1016/s0140-6736(89)90710-1). Many subsequent studies have affirmed the relationship between birth weight and conditions such as diabetes, hypertension, and obesity. In this volume of The Journal of Pediatrics, Lilja et al report an association between birth weight and stroke in adulthood.
Source: The Journal of Pediatrics - September 22, 2021 Category: Pediatrics Authors: Raye-Ann deRegnier Tags: The Editors' Perspectives Source Type: research
Primary Hypertension Beginning in Childhood and Risk for Future Cardiovascular Disease
Hypertension in adulthood continues to be a leading cause of morbidity and mortality worldwide.1 Hypertension in childhood is not uncommon, but due to the absence of data on future adverse outcomes (heart failure, stroke, kidney failure) hypertension has been defined in childhood as systolic or diastolic blood pressure (BP)>95th percentile of age, sex, and height adjusted normative BP data. The prevalence of childhood hypertension is approximately 4 percent, and the prevalence of elevated BP, a condition of higher risk for progression to hypertension, is approximately 10 percent.
Source: The Journal of Pediatrics - August 12, 2021 Category: Pediatrics Authors: Bonita Falkner, Empar Lurbe Tags: Medical Progress Source Type: research
Low Birth Weight as an Early-Life Risk Factor for Adult Stroke Among Men
To evaluate the association between birth weight and the risk of adult stroke in men, independent of body mass index (BMI) at young adult age.
Source: The Journal of Pediatrics - June 26, 2021 Category: Pediatrics Authors: Lina Lilja, Maria Bygdell, Jari Martikainen, Annika Rosengren, Claes Ohlsson, Jenny M. Kindblom Tags: Original Article Source Type: research
Low Birth Weight as an Early Life Risk Factor for Adult Stroke Among Men
To evaluate the association between birth weight and the risk of adult stroke in men, independent of body mass index (BMI) at young adult age.
Source: The Journal of Pediatrics - June 26, 2021 Category: Pediatrics Authors: Lina Lilja, Maria Bygdell, Jari Martikainen, Annika Rosengren, Claes Ohlsson, Jenny M. Kindblom Tags: Original Articles Source Type: research
Mitochondrial Disease and Coenzyme Q10 Deficiency: Commentary
Mitochondrial disorders may present from birth to adulthood and are characterized by dysfunction of the mitochondrial respiratory chain due to pathogenic variants in mitochondrial DNA (mtDNA) or nuclear DNA, with an estimated incidence of 1/5000 1. Mitochondrial disorders have a broad phenotypic spectrum and may fall into one of several classic phenotypic presentations (e.g., mitochondrial encephalopathy with lactic acidosis and stroke-like episodes: MELAS; Leber hereditary optic neuropathy: LHON; myoclonic epilepsy with ragged red fibers: MERRF, Kearns-Sayre syndrome: KSS, among others) or may present with variable sympto...
Source: The Journal of Pediatrics - September 19, 2020 Category: Pediatrics Authors: Audrey C. Woerner, Jerry Vockley Tags: Editorials Source Type: research
Structural Connectomics: State of the Art and Applications in Pediatric Neurodevelopmental Disorders, Neuro-Oncology, and Arterial Ischemic Stroke
The human connectome reflects the agenda for the new era of brain networks.1 The connectome represents the structural and functional layout of brain networks and often is represented as a mathematical grid.2-4 Brain network graphs provide a simplified view of the human brain connectome, using graph theory to abstractly define the brain as a set of anatomical regions (or “nodes”) and structural connections (called “edges”).4,5
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Avner Meoded, Neil A. Goldenberg, Thierry A.G. M. Huisman Tags: Supplement Source Type: research
Do you hear what I hear? ECHO and autism
Autism spectrum disorder (ASD) is now estimated to occur in 1 of every 59 children in the US. The direct and indirect costs of caring for children and adults affected by ASD in 2015 dollars exceeded the cost of hypertension and stroke (Pediatrics 2020;145:e20193447). For these reasons and so many others, it is vital that general pediatricians and other primary care providers (PCPs) are able to recognize, screen, refer, and care for the many comorbidities that affect children and adolescents with ASD.
Source: The Journal of Pediatrics - May 21, 2020 Category: Pediatrics Authors: Jane Oski Tags: The Editors' Perspectives Source Type: research
Pediatric Acute Stroke Protocol Implementation and Utilization Over 7 Years
To examine the implementation and utilization of a pediatric acute stroke protocol over a 7-year period, hypothesizing improvements in protocol implementation and increased protocol use over time.
Source: The Journal of Pediatrics - March 4, 2020 Category: Pediatrics Authors: Jessica D. Wharton, Megan M. Barry, Chelsea A. Lee, Kayla Massey, Travis R. Ladner, Lori C. Jordan Tags: Original Articles Source Type: research
How old am I really?
Telomeres are repetitive nucleotides sequences localized to the ends of each individual chromosome. They are replicated during each cellular division, but with each cell cycle they become progressively shorter. The problem is short telomeres are associated with dysregulation of cellular events such as senescence or cell death. The shortening process is accelerated by exposure to stress, smoking, obesity, lack of exercise, and poor diet. Many refer to this process as one of our “biological clocks.” In long-term studies, shortened telomeres are associated with adverse health outcomes including atherosclerosis, stroke, and Type 2 diabetes.
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: James F. Padbury Tags: The Editors' Perspectives Source Type: research
Transcranial Doppler Screening Adherence among Children with Sickle Cell Anemia Seen in the Emergency Department
To evaluate adherence to annual transcranial Doppler ultrasound (TCD) screening to prevent stroke among patients with sickle cell anemia (SCA) seen in the emergency department (ED).
Source: The Journal of Pediatrics - November 20, 2019 Category: Pediatrics Authors: Julie K. Weisman, Carrie E. Diamond, Sarah Kappa, Robert Sheppard Nickel Tags: Original Articles Source Type: research
A Stroke Alert Protocol Decreases the Time to Diagnosis of Brain Attack Symptoms in a Pediatric Emergency Department
To determine whether a stroke alert system decreases the time to diagnosis of children presenting to the emergency department (ED) with acute-onset focal neurologic deficits.
Source: The Journal of Pediatrics - November 4, 2019 Category: Pediatrics Authors: Dana B. Harrar, Catherine L. Salussolia, Kush Kapur, Amy Danehy, Monica E. Kleinman, Rebekah Mannix, Michael J. Rivkin Tags: Original Articles Source Type: research
Varicella-Associated Stroke
A previously healthy, unimmunized 11-month-old boy presented with acute right-sided weakness. On the day of presentation, his mother noted that his right arm and leg seemed to be weak when she woke him from his usual afternoon nap. Evaluation at an urgent care center confirmed right-sided facial weakness, decreased strength and movement of his right upper and lower extremities, and a lack of right-sided support in a sitting position. Computed tomography of the head without contrast was normal. He was transferred to a regional care center where head magnetic resonance imaging and magnetic resonance angiography demonstrated ...
Source: The Journal of Pediatrics - April 19, 2018 Category: Pediatrics Authors: Surabhi B. Vora, Catherine Amlie-Lefond, Francisco A. Perez, Ann J. Melvin Tags: Insights and Images Source Type: research
