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Pediatric Acute Stroke Protocols in the United States and Canada
To describe existing pediatric acute stroke protocols to understand better how pediatric centers might implement such pathways within the context of institution-specific structures.
Source: The Journal of Pediatrics - November 10, 2021 Category: Pediatrics Authors: Dana B. Harrar, Giulia M. Benedetti, Anuj Jayakar, Jessica L. Carpenter, Tara K. Mangum, Melissa Chung, Brian Appavu, International Pediatric Stroke Study Group, Pediatric Neurocritical Care Research Group Tags: Original Articles Source Type: research

Antithrombotic Therapy for Secondary Stroke Prevention in Bacterial Meningitis in Children
Conclusion: In this small sample, heparin and ASA appeared to be safe in childhood bacterial meningitis complicated by stroke and may be effective in improving outcome. Heparin may be more effective than aspirin in preventing recurrent infarction.
Source: The Journal of Pediatrics - July 24, 2014 Category: Pediatrics Authors: Cyrus Boelman, Manohar Shroff, Ivanna Yau, Bruce Bjornson, Susan Richrdson, Gabrielle deVeber, Daune MacGregor, Mahendranathn Moharir, Rand Askalan Tags: Original Articles Source Type: research

The Pediatric Stroke Code: Early Management of the Child with Stroke
Stroke in children is estimated to occur as frequently as brain tumors, and acute presentations should be considered a neurologic emergency. Although stroke is less common in children than in adults, the long-term morbidity and societal impact of stroke in children likely exceeds that in adults.1 Lessons from adult stroke trials underscore the need for early therapy to prevent complications and improve outcomes. In children, the prompt diagnosis of stroke is challenging, and a delay in diagnosis is a major impediment to initiating therapy.
Source: The Journal of Pediatrics - April 30, 2015 Category: Pediatrics Authors: Jorina Elbers, Mark S. Wainwright, Catherine Amlie-Lefond Tags: Medical Progress Source Type: research

Pediatric Ischemic Stroke: Acute Management and Areas of Research
Stroke is defined as the rapid loss of brain function due to a decreased cerebral blood flow (CBF). It is a relatively rare disease in childhood, with an estimated incidence of 2.6-6.4/100 000/year and serious long-term morbidity. Ischemic stroke in children typically refers to arterial ischemic stroke (AIS). It is more frequent in the perinatal period (between 28 weeks of gestation to 28 days after birth) than in childhood (; available at www.jpeds.com). The clinical presentation of AIS differs depending on age, involved artery, and cause. In newborns, seizures, apneas, hypotonia, episodes of duskiness, irritability, or ...
Source: The Journal of Pediatrics - November 15, 2012 Category: Pediatrics Authors: Luigi Titomanlio, Anna Zanin, Philippe Sachs, Jinane Khaled, Monique Elmaleh, Raphael Blanc, Michel Piotin Tags: Medical Progress Source Type: research

Feasibility and Safety of Erythropoietin for Neuroprotection after Perinatal Arterial Ischemic Stroke
Conclusions: rhEPO in neonates with perinatal arterial ischemic stroke had no adverse effects on red blood cells, white blood cells, platelets counts, or coagulation. rhEPO, 3000 IU/kg in total, given during a 3-day period, appears to be a safe therapy. The beneficial effects remains to be demonstrated in a larger, randomized, double-blind, placebo-controlled trial.
Source: The Journal of Pediatrics - December 9, 2013 Category: Pediatrics Authors: Manon J. Benders, Niek E. van der Aa, Maurice Roks, Henrica L. van Straaten, Ivana Isgum, Max A. Viergever, Floris Groenendaal, Linda S. de Vries, Frank van Bel Tags: Original Articles Source Type: research

Arteriopathy, D-Dimer, and Risk of Poor Neurologic Outcome in Childhood-Onset Arterial Ischemic Stroke
Conclusion: Arteriopathy and coagulation activation are highly prevalent in the acute period of childhood AIS. Although recurrent AIS and intracranial hemorrhage were infrequent in our cohort, one-half of children experienced a poor neurologic outcome at 1 year, the risk of which was increased by acute arteriopathy. Substantiation of these findings in multi-institutional cohort studies is warranted, toward risk stratification in childhood-onset AIS.
Source: The Journal of Pediatrics - December 20, 2012 Category: Pediatrics Authors: Neil A. Goldenberg, Sarah Jenkins, Jessica Jack, Jennifer Armstrong-Wells, Laura Z. Fenton, Nicholas V. Stence, Joyce Oleszek, Richard Boada, Greta N. Wilkening, Charles Wilkinson, Jennifer B. Soep, Shelley D. Miyamoto, Lalit Bajaj, Peter M. Mourani, Mari Tags: Original Articles Source Type: research

Neonatal Forearm Compartment Syndrome: Look for Cerebral Stroke
A male term newborn presented with a neonatal forearm compartment syndrome together with an ipsilateral cerebral stroke. Pregnancy and delivery were uneventful, except for oligohydramnios. His mother had celiac disease and hypothyroidism. Since birth, he showed a 4-cm bullous-ulcerated lesion on the left volar forearm and elbow fold (, A), with normal pulses, and an ipsilateral upper limb paresis with reduced motility, dropped wrist, no fingers extension, and grasping. Tendon reflexes were normal with Babinski sign bilaterally evident. Radiography showed a mild carpus asymmetry (left left). He had a residual scar on the fo...
Source: The Journal of Pediatrics - November 18, 2013 Category: Pediatrics Authors: Elena Pavlidis, Carlotta Spagnoli, Maddalena Duca, Francesca Ormitti, Cinzia Magnani, Francesco Pisani Tags: Insights and Images Source Type: research

Antithrombotic therapy for secondary stroke prevention in meningitis
In this issue of The Journal, Boelman et al present a 15-year retrospective cohort experience of management and follow-up of 22 patients with stroke complicating bacterial meningitis cared for at the Hospital for Sick Children, Toronto, and the British Columbia Children's Hospital, Vancouver.
Source: The Journal of Pediatrics - September 25, 2014 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: research

Multimodal Outcome at 7 Years of Age after Neonatal Arterial Ischemic Stroke
To evaluate the epileptic, academic, and developmental status at age 7 years in a large population of term-born children who sustained neonatal arterial ischemic stroke (NAIS), and to assess the co-occurrence of these outcomes.
Source: The Journal of Pediatrics - March 9, 2016 Category: Pediatrics Authors: Stéphane Chabrier, Emeline Peyric, Laure Drutel, Johanna Deron, Manoëlle Kossorotoff, Mickaël Dinomais, Leila Lazaro, Jérémie Lefranc, Guillaume Thébault, Gérard Dray, Joel Fluss, Cyrille Renaud, Sylvie Nguyen The Tich, Accident Vasculaire Cérébr Tags: Original Article Source Type: research

Risk Factors for Neonatal Arterial Ischemic Stroke: The Importance of the Intrapartum Period
To investigate risk factors for neonatal arterial ischemic stroke (NAIS), and compare them with those present in term controls and infants with hypoxic-ischemic encephalopathy (HIE).
Source: The Journal of Pediatrics - April 1, 2016 Category: Pediatrics Authors: Miriam Martinez-Biarge, Jeanie L.Y. Cheong, Jesus Diez-Sebastian, Eugenio Mercuri, Lilly M.S. Dubowitz, Frances M. Cowan Tags: Original Article Source Type: research

Are neonatal stroke and hypoxic-ischemic encephalopathy related?
Perinatal asphyxia is known to be a risk factor for neonatal arterial ischemic stroke (NAIS) and hypoxic-ischemic encephalopathy (HIE), and HIE can play a role in the pathogenesis of NAIS. Do NAIS and HIE share antepartum or intrapartum risk factors and perhaps causal pathways?
Source: The Journal of Pediatrics - May 24, 2016 Category: Pediatrics Authors: Paul G. Fisher Tags: The Editors' Perspectives Source Type: research

Utility of Neurovascular Imaging in Acute Neonatal Arterial Ischemic Stroke
To evaluate the prevalence of magnetic resonance angiography (MRA) findings and clinically characterize neonates with arterial ischemic stroke (AIS) who have abnormal or variable vasculature.
Source: The Journal of Pediatrics - June 14, 2017 Category: Pediatrics Authors: Ishita Siddiq, Derek Armstrong, Ann-Marie Surmava, Nomazulu Dlamini, Daune MacGregor, Mahendranath Moharir, Rand Askalan Tags: Original Articles Source Type: research

Placental Pathology in Neonatal Stroke: A Retrospective Case-Control Study
To assess the association of placental abnormalities with neonatal stroke.
Source: The Journal of Pediatrics - February 4, 2018 Category: Pediatrics Authors: Miya E. Bernson-Leung, Theonia K. Boyd, Emily E. Meserve, Amy R. Danehy, Kush Kapur, Cameron C. Trenor, Laura L. Lehman, Michael J. Rivkin Tags: Original Articles Source Type: research

Varicella-Associated Stroke
A previously healthy, unimmunized 11-month-old boy presented with acute right-sided weakness. On the day of presentation, his mother noted that his right arm and leg seemed to be weak when she woke him from his usual afternoon nap. Evaluation at an urgent care center confirmed right-sided facial weakness, decreased strength and movement of his right upper and lower extremities, and a lack of right-sided support in a sitting position. Computed tomography of the head without contrast was normal. He was transferred to a regional care center where head magnetic resonance imaging and magnetic resonance angiography demonstrated ...
Source: The Journal of Pediatrics - April 19, 2018 Category: Pediatrics Authors: Surabhi B. Vora, Catherine Amlie-Lefond, Francisco A. Perez, Ann J. Melvin Tags: Insights and Images Source Type: research

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