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Neuregulin-1/PI3K signaling effects on oligodendrocyte proliferation, remyelination and behaviors deficit in a male mouse model of ischemic stroke
In this study, we investigated the effect of neuregulin-1 (NRG1) on demyelination and neurological function in an ischemic stroke model, and further explored its neuroprotective mechanisms. Adult male ICR mice underwent photothrombotic ischemia surgery and were injected with NRG1 beginning 30 min after ischemia. Cylinder and grid walking tests were performed to evaluate the forepaw function. In addition, the effect of NRG1 on neuronal damage/death (Cresyl violet, CV), neuronal nuclei (NeuN), nestin, doublecortin (DCX), myelin basic protein (MBP), non-phosphorylated neurofilaments (SMI-32), adenomatous polyposis coli (APC),...
Source: Experimental Neurology - January 23, 2023 Category: Neurology Authors: Mai Yin Cui Yan Qiong Fu Zhuo Li Li Yu Zheng Yi Yu Chan Zhang Yun Qi Zhang Bing Rui Gao Wu Yue Chen Yun-Lyul Lee Moo-Ho Won Min Liao Yong Jian Bai Hui Chen Source Type: research

The Clinical Impact of Methotrexate-Induced Stroke-Like Neurotoxicity in Paediatric Departments: An Italian Multi-Centre Case-Series
ConclusionsSLS is a rare, well-characterized complication of MTX administration. Despite the small sample, we have been able to confirm some of the previous findings in literature. We also identified a linear correlation between age and severity of the disease, which could improve the future clinical management.
Source: Frontiers in Neurology - June 10, 2022 Category: Neurology Source Type: research

Seizures during treatment of childhood acute lymphoblastic leukemia: A population-based cohort study.
CONCLUSION: Seizures are relatively common in ALL patients and occur most often in patients with PRES, SVT, or as an isolated symptom. Older children have higher risk of seizures. PMID: 32340855 [PubMed - as supplied by publisher]
Source: European Journal of Paediatric Neurology - April 17, 2020 Category: Neurology Authors: Anastasopoulou S, Heyman M, Eriksson MA, Niinimäki R, Taskinen M, Mikkel S, Vaitkeviciene GE, Johannsdottir IM, Myrberg IH, Jonsson OG, Als-Nielsen B, Schmiegelow K, Banerjee J, Ranta S, Harila-Saari A Tags: Eur J Paediatr Neurol Source Type: research

A Unique Presentation of Pediatric Stroke Attributed to Intrathecal Methotrexate (P3.309)
CONCLUSIONS:This is a rare case of ischemic watershed infarcts with diffuse reversible cerebral vasospasm, after intrathecal methotrexate. This highlights the need for further research into the pathogenesis of methotrexate neurotoxicity including endothelial damage.Study Supported by:Disclosure: Dr. Ilyas has nothing to disclose. Dr. Williams has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ilyas, M., Williams, M. Tags: Neurologic Complications of Cancer Source Type: research

Role of beta‐defensin 2 and interleukin‐4 receptor as stroke outcome biomarkers
Abstract Acute ischemic stroke is a complex disease with huge interindividual evolution variability that makes challenging the prediction of an adverse outcome. Our aim was to study the association of bloodstream signatures to early neurological outcome after stroke, by combining a subpooling of samples strategy with protein array discovery approach. Plasma samples from 36 acute stroke patients (< 4.5 h from onset) were equally pooled within outcome groups: worsening, stability, and improvement (n = 3 pools of four patients each, for each outcome group). These nine pools were screened using a 177 antibodies library,...
Source: Journal of Neurochemistry - February 11, 2014 Category: Neurology Authors: Teresa García‐Berrocoso, Dolors Giralt, Alejandro Bustamante, Victor Llombart, Marta Rubiera, Anna Penalba, Cristina Boada, Marc Espadaler, Carlos Molina, Joan Montaner Tags: Original Article Source Type: research