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Novel TIA biomarkers identified by mass spectrometry ‐based proteomics
ConclusionsUtilizing mass spectrometry‐based proteomics, platelet basic protein has been identified as a candidate serum biomarker for transient ischemic attack. This unbiased proteomic approach may be a promising method to identify novel biomarkers to more precisely diagnose transient ischemic attacks.
Source: International Journal of Stroke - August 25, 2015 Category: Neurology Authors: Paul M. George, Michael Mlynash, Christopher M. Adams, Calvin J. Kuo, Gregory W. Albers, Jean ‐Marc Olivot Tags: Research Source Type: research

Effective Education Materials to Advance Stroke Awareness Without Teacher Participation in Junior High School Students
Youth stroke education is promising for the spread of stroke awareness. The aim of this study was to examine whether our stroke awareness teaching materials without teacher's participation can increase student awareness to act fast on suspected stroke signs.
Source: Journal of Stroke and Cerebrovascular Diseases - July 28, 2015 Category: Neurology Authors: Satoshi Ohyama, Chiaki Yokota, Fumio Miyashita, Tatsuo Amano, Yasuteru Inoue, Yuya Shigehatake, Yuki Sakamoto, Kazunori Toyoda, Kazuo Minematsu Source Type: research

Quality of In-Hospital Stroke Care in Veterans Affairs Hospitals (P5.146)
Conclusions: Veterans who develop an in-hospital stroke receive similar quality of care as patients presenting to the ED although fewer in-hospital patients had dysphagia screening. Interestingly, tPA eligibility and utilization were higher for in-hospital strokes although utilization did not reach significance. While it is reassuring that in-hospital strokes are receiving similar quality of care, there is still room for improvement in all patient care settings and in-hospital stroke patients should be included in future QI processes.Disclosure: Dr. Lyerly has nothing to disclose. Dr. Sager has nothing to disclose. Dr. Cof...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lyerly, M., Sager, D., Coffing, J., Damush, T., Cutter, G., King, P., Williams, L. Tags: Cerebrovascular Disease and Interventional Neurology: Quality Research and Initiatives Source Type: research

The Presence of an Advanced Practice Nurse Stroke Program Coordinator Decreases Door-to-Needle Times (P5.149)
CONCLUSIONS: The presence of an APN SPC was associated with reduced median DTN times. The presence of an APN SPC, in addition to an on duty neurologist, may reduce time between door and needle, engendering improvements in patient outcomes.Disclosure: Dr. Whaley has nothing to disclose. Dr. Caputo has nothing to disclose. Dr. Wagner has received personal compensation for activities with Genentech, Inc.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Whaley, M., Caputo, L., Wagner, J. Tags: Cerebrovascular Disease and Interventional Neurology: Quality Research and Initiatives Source Type: research

TIA Biomarkers Determined Through Proteomics (S30.002)
Conclusions: PBP has been identified as potential serum biomarker for TIA. Larger sample size may find that ceruloplasmin is an additional candidate. Ultimately, a panel of proteins may be required. Larger studies are needed to determine the validity of these proteins in clinical use.Disclosure: Dr. George has nothing to disclose. Dr. Mlynash has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Kuo has nothing to disclose. Dr. Kemp has nothing to disclose. Dr. Garcia has nothing to disclose. Dr. Albers has received personal compensation for activities with Genentech, Inc. and Lundbeck Research USA, Inc. as an ad...
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, P., Mlynash, M., Adams, C., Kuo, C., Kemp, S., Garcia, M., Albers, G., Olivot, J.-M. Tags: Cerebrovascular Disease and Interventional Neurology: Diagnostics, Biomarkers, and Genetics Platform Blitz Source Type: research

Significance of Periclot MMP-9 in Ischemic Stroke Patients Undergoing Intra-arterial Interventions (P4.303)
CONCLUSIONS: Decreased periclot MMP-9 may be predictive of HT after ischemic stroke, contrasting with previous work demonstrating elevated peripheral MMP-9 as predictive of HT. Increased periclot MCP-4 and angiogenin expression, as well as decreased numbers of circulating monocytes, may serve as additional predictive markers of HT. Future work should measure the activity of periclot MMP-9. Study Supported by: Shimojani, LLC and NIH (DJ).Disclosure: Dr. Song has nothing to disclose. Dr. Prager has nothing to disclose. Dr. Brennan has nothing to disclose. Dr. Uchino has nothing to disclose. Dr. Hussain has nothing to disclos...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Song, A., Prager, B., Brennan, C., Uchino, K., Hussain, M., Rasmussen, P., Janigro, D. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Interventional Treatment for Ischemic Stroke Source Type: research

TIA Biomarkers Determined Through Proteomics (I11-1A)
Conclusions: PBP has been identified as potential serum biomarker for TIA. Larger sample size may find that ceruloplasmin is an additional candidate. Ultimately, a panel of proteins may be required. Larger studies are needed to determine the validity of these proteins in clinical use.Disclosure: Dr. George has nothing to disclose. Dr. Mlynash has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Kuo has nothing to disclose. Dr. Kemp has nothing to disclose. Dr. Garcia has nothing to disclose. Dr. Albers has received personal compensation for activities with Genentech, Inc. and Lundbeck Research USA, Inc. as an ad...
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, P., Mlynash, M., Adams, C., Kuo, C., Kemp, S., Garcia, M., Albers, G., Olivot, J.-M. Tags: The Promise of Novel Biomarker Approaches in Advancing Treatment Data Blitz Presentations Source Type: research

Rate of Peri-Hematomal Edema Expansion Predicts Outcome after Intracerebral Hemorrhage (S39.005)
CONCLUSIONS: PHE expansion rate predicts outcome in ICH and may represent a novel therapeutic target. Study Supported by: NIH-K12-NS049453 (LB); NINDS K23NS076597 (WTK); Leon Rosenberg, MD Medical Student Research Fund in Genetics, Yale School of Medicine; 2014 Student Scholarship in Cerebrovascular Disease and Stroke, AHA Stroke Council (SU)Disclosure: Dr. Urday has nothing to disclose. Dr. Beslow has nothing to disclose. Dr. Goldstein has nothing to disclose. Dr. Dai has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Vashkevich has received research support from the National Institutes of Health. Dr. Ayres h...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Urday, S., Beslow, L., Goldstein, D., Dai, F., Zhang, F., Vashkevich, A., Ayres, A., Battey, T., Simard, M., Rosand, J., Kimberly, W., Sheth, K. Tags: Cerebrovascular Disease and Interventional Neurology: Intracerebral Hemorrhage Source Type: research

Assessment of Stroke Knowledge and Attitudes among Riyadh Medical Students: A Cross-sectional Study (P2.303)
CONCLUSIONS: This study demonstrated average medical students’ knowledge of stroke and identified knowledge gaps in different domains of basic stroke knowledge. Stroke education modules should be incorporated into the preclinical curriculum and neurology or stroke clerkships should be mandatory for all students. Emphasizing the high risk of stroke recurrence in patients with minor or transient symptoms is crucial for decreasing the burden of stroke.Disclosure: Dr. Al Zwahmah has received personal compensation in an editorial capacity for Neurosciences Journal.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Alzawahmah, M. Tags: Cerebrovascular Disease and Interventional Neurology: Education and TIA Source Type: research

Anxiety influences TIA diagnosis (P7.134)
Conclusions: We found an elevated TIA-IS ratio among patients with a concurrent ICD9 code for anxiety. The ABCD2 score, assessing symptoms and vascular risk factors, is promoted as a criterion for admission; however, these data suggest that comorbid conditions such as anxiety along with demographic and hospital factors also influence TIA diagnosis. The validity and meaning of an ICD9 code for anxiety is uncertain. The code may be associated with over-diagnosis of TIA as well as increased recognition of true TIA.Disclosure: Dr. Sugrue has nothing to disclose. Dr. Bhupali has nothing to disclose. Dr. Labovitz has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Sugrue, W., Bhupali, D., Labovitz, D. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke, Depression, and Anxiety Source Type: research

A Novel Method for Measuring Oxidative Stress in Patients with Stroke Symptoms (S52.005)
CONCLUSIONS: These results demonstrate the ability of ORP to identify oxidative stress and amount of antioxidant reserves in a stroke population. We propose ORP monitoring as a potentially useful tool in evaluation of acute stroke patients.Disclosure: Dr. Wagner has received personal compensation for activities with Genentech, Inc. Dr. Salottolo has nothing to disclose. Dr. Fanale has received personal compensation for activities with Genentech, Inc. as a speaker. Dr. Whaley has nothing to disclose. Dr. McCarthy has nothing to disclose. Luoxis Diagnostics, Inc,
Source: Neurology - April 8, 2015 Category: Neurology Authors: Wagner, J., Salottolo, K., Fanale, C., Whaley, M., McCarthy, K., BarOr, D. Tags: General Neurology: Neural Networks and Neuromodulation Source Type: research

Internet Teaching of the Neurologic Examination and OSCE Performance in the Neurology Clerkship (s19.006)
CONCLUSIONS Using www.neuroexam.com significantly improved students’ performance on a Stroke OSCE compared to online NIHSS training, with similar trends for Headache and Neuropathy. General neurologic examination training rather than focused stroke examination training may be more helpful for students, even when examining stroke patients. Online websites with teaching videos may represent a viable model for improving students’ skills with the neurologic examination. Study supported by: 2013 AAN Education Research GrantDisclosure: Dr. Harth has nothing to disclose. Dr. Xue has nothing to disclose. Dr. Yang has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Harth, C., Xue, Y., Yang, J. Tags: Neurologic Education Source Type: research

Resting Energy Expenditure in Patients with Stroke during the Subacute Phases - Relationships with Stroke Types, Location, Severity of Paresis, and Activities of Daily Living
Background: The energy demands in patients with stroke during the subacute phases are unclear. However, this information is essential for appropriate clinical and nutritional management. The aims of this study were to determine the resting energy expenditure (REE) during the subacute phases, examine its relationships with stroke types, location, severity of hemiparesis, and activities of daily living (ADL), and evaluate whether estimation of REE from the Harris-Benedict equation (HB) requires the addition of a ‘stress factor' to capture possible additional REE imposed by stroke. Methods: We measured REE in 95 patients wi...
Source: Cerebrovascular Diseases - February 26, 2015 Category: Neurology Source Type: research

Detection of Symptomatic Carotid Plaque Using Source Data from MR and CT Angiography: A Correlative Study
Background: Carotid plaque MRI has been a useful method to characterize vulnerable atherosclerotic plaque elements. Recent investigations have suggested that source images from CT angiography (CTA) and MR angiography (MRA) can identify the simple high-risk features of symptom-producing carotid artery plaque. We studied the correlation and relative diagnostic accuracies of CTA and MRA source images in detecting symptomatic carotid artery plaque. Methods: Subjects were eligible if they had carotid stenosis between 50 and 99% and had MRA and CTA exams performed within 10 days of one another. We measured the soft (non-calcifie...
Source: Cerebrovascular Diseases - February 16, 2015 Category: Neurology Source Type: research

Effects of Stroke Education of Junior High School Students on Stroke Knowledge of Their Parents: Tochigi Project Brief Reports
Conclusions— Improvement of stroke knowledge immediately after the stroke lesson was observed in parents as well as their children, which indicated that our teaching materials using the Manga was effective in delivering the stroke knowledge to parents through their children.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Matsuzono, K., Yokota, C., Takekawa, H., Okamura, T., Miyamatsu, N., Nakayama, H., Nishimura, K., Ohyama, S., Ishigami, A., Okumura, K., Toyoda, K., Miyamoto, Y., Minematsu, K., on behalf of the Tochigi Junior High School Stroke Education Group, Participa Tags: Behavioral Changes and Stroke Brief Reports Source Type: research

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