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Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association. Introduction Cerebral amyloid angiopathy (CAA)—characterized by the deposition of ß-amyloid in the walls of leptomeningeal vessels—is a common cerebral small vessel disease and a major cause of intracerebral hemorrhage in the elderly (1–3). Furthermore, it has become evident that CAA is associated with cognitive impairment (4). Specifically, it has been shown that ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

The Predictive Capacity of the Buffalo Concussion Treadmill Test After Sport-Related Concussion in Adolescents
Conclusion This study found that the ΔHR (HRt minus resting HR) correlated with duration of clinical recovery in participants who were prescribed relative rest or a placebo-stretching program but not for participants prescribed sub-threshold aerobic exercise. A ΔHR of ≤50 bpm on the BCTT was 73% sensitive and 78% specific for predicting delayed recovery in concussed adolescents prescribed the current standard of care (i.e., cognitive and physical rest). This has implications for planning team and school activities in adolescents who sustain SRC. Ethics Statement This study was carried out in acco...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Novel TIA biomarkers identified by mass spectrometry‐based proteomics
ConclusionsUtilizing mass spectrometry‐based proteomics, platelet basic protein has been identified as a candidate serum biomarker for transient ischemic attack. This unbiased proteomic approach may be a promising method to identify novel biomarkers to more precisely diagnose transient ischemic attacks.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Paul M. George, Michael Mlynash, Christopher M. Adams, Calvin J. Kuo, Gregory W. Albers, Jean‐Marc Olivot Tags: Research Source Type: research

Novel TIA biomarkers identified by mass spectrometry ‐based proteomics
ConclusionsUtilizing mass spectrometry‐based proteomics, platelet basic protein has been identified as a candidate serum biomarker for transient ischemic attack. This unbiased proteomic approach may be a promising method to identify novel biomarkers to more precisely diagnose transient ischemic attacks.
Source: International Journal of Stroke - August 25, 2015 Category: Neurology Authors: Paul M. George, Michael Mlynash, Christopher M. Adams, Calvin J. Kuo, Gregory W. Albers, Jean ‐Marc Olivot Tags: Research Source Type: research

TIA Biomarkers Determined Through Proteomics (S30.002)
Conclusions: PBP has been identified as potential serum biomarker for TIA. Larger sample size may find that ceruloplasmin is an additional candidate. Ultimately, a panel of proteins may be required. Larger studies are needed to determine the validity of these proteins in clinical use.Disclosure: Dr. George has nothing to disclose. Dr. Mlynash has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Kuo has nothing to disclose. Dr. Kemp has nothing to disclose. Dr. Garcia has nothing to disclose. Dr. Albers has received personal compensation for activities with Genentech, Inc. and Lundbeck Research USA, Inc. as an ad...
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, P., Mlynash, M., Adams, C., Kuo, C., Kemp, S., Garcia, M., Albers, G., Olivot, J.-M. Tags: Cerebrovascular Disease and Interventional Neurology: Diagnostics, Biomarkers, and Genetics Platform Blitz Source Type: research

TIA Biomarkers Determined Through Proteomics (I11-1A)
Conclusions: PBP has been identified as potential serum biomarker for TIA. Larger sample size may find that ceruloplasmin is an additional candidate. Ultimately, a panel of proteins may be required. Larger studies are needed to determine the validity of these proteins in clinical use.Disclosure: Dr. George has nothing to disclose. Dr. Mlynash has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Kuo has nothing to disclose. Dr. Kemp has nothing to disclose. Dr. Garcia has nothing to disclose. Dr. Albers has received personal compensation for activities with Genentech, Inc. and Lundbeck Research USA, Inc. as an ad...
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, P., Mlynash, M., Adams, C., Kuo, C., Kemp, S., Garcia, M., Albers, G., Olivot, J.-M. Tags: The Promise of Novel Biomarker Approaches in Advancing Treatment Data Blitz Presentations Source Type: research

Internet Teaching of the Neurologic Examination and OSCE Performance in the Neurology Clerkship (s19.006)
CONCLUSIONS Using www.neuroexam.com significantly improved students’ performance on a Stroke OSCE compared to online NIHSS training, with similar trends for Headache and Neuropathy. General neurologic examination training rather than focused stroke examination training may be more helpful for students, even when examining stroke patients. Online websites with teaching videos may represent a viable model for improving students’ skills with the neurologic examination. Study supported by: 2013 AAN Education Research GrantDisclosure: Dr. Harth has nothing to disclose. Dr. Xue has nothing to disclose. Dr. Yang has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Harth, C., Xue, Y., Yang, J. Tags: Neurologic Education Source Type: research

Effects of Stroke Education of Junior High School Students on Stroke Knowledge of Their Parents: Tochigi Project Brief Reports
Conclusions— Improvement of stroke knowledge immediately after the stroke lesson was observed in parents as well as their children, which indicated that our teaching materials using the Manga was effective in delivering the stroke knowledge to parents through their children.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Matsuzono, K., Yokota, C., Takekawa, H., Okamura, T., Miyamatsu, N., Nakayama, H., Nishimura, K., Ohyama, S., Ishigami, A., Okumura, K., Toyoda, K., Miyamoto, Y., Minematsu, K., on behalf of the Tochigi Junior High School Stroke Education Group, Participa Tags: Behavioral Changes and Stroke Brief Reports Source Type: research

Identifying Novel Biomarkers of Cerebral Ischemia through the Use of Mass Spectroscopy (S15.004)
CONCLUSIONS: Mass spectroscopy-based proteomics is a potential new tool to help identify biomarkers for cerebral ischemia. Ultimately, a panel of proteins may serve as a marker for cerebral ischemia or TIA. We have identified three candidate proteins as possible indicators for cerebral ischemia. Larger studies are needed to confirm our results. Study Supported by: Stanford Cardiovascular Institute; American Brain Foundation and American Academy of Neurology Clinical Research Training FellowshipDisclosure: Dr. George has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Mlynash has nothing to disclose. Dr. Kjaerga...
Source: Neurology - April 9, 2014 Category: Neurology Authors: George, P., Adams, C., Mlynash, M., Kjaergaard, C., Kuo, C., Kemp, S., Garcia, M., Albers, G., Olivot, J.-M. Tags: Cerebrovascular Disease and Interventional Neurology: Clinical and Imaging Biomarkers and Genetics Source Type: research

Taking Neurology to the Underserved - A Pilot Initiative in an Urban Homebound Program (P6.007)
CONCLUSIONS: Our pilot program highlights types of chronic neurologic illnesses afflicting the homebound population, treatment interventions utilized, and clinical challenges encountered. By considering the real-world intersection of disease and living environment, trainees gained perspective on the debilitating impact of neurological illness on homebound patients. This pilot program reveals the need and feasibility of neurological home based care as an important clinical, educational, and palliative paradigm.Disclosure: Dr. Ramdhani has nothing to disclose. Dr. Fabian has received personal compensation for activities with...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ramdhani, R., Fabian, M., Wajnberg, A., DeCherrie, L., Krieger, S. Tags: General Neurology V Source Type: research

Awareness of Risk Factors and Warning Signs of Stroke in a Nigeria University
This study assessed awareness of stroke risk factors and warning signs among students and staff of Obafemi Awolowo University, Nigeria.Methods: This was a cross sectional survey involving 994 (500 students and 494 staff) respondents. Information on the awareness of stroke risk factors and warning signs was collected with the aid of a structured questionnaire. Descriptive and inferential statistics were used for data analysis.Results: Weakness (66.2%) was the most commonly identified warning sign of stroke with more staff (69.8%) identifying correctly than students (62.6%). Hypertension (83.4%) was the most commonly identif...
Source: Journal of Stroke and Cerebrovascular Diseases - August 1, 2013 Category: Neurology Authors: Adebimpe O. Obembe, Matthew O. Olaogun, Adesola A. Bamikole, Morenikeji A. Komolafe, Marufat O. Odetunde Tags: Original Articles Source Type: research