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Specialty: Neurology
Condition: Diabetes

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Total 1939 results found since Jan 2013.

Aspirin for Stroke Prevention in Elderly Patients With Vascular Risk Factors: Japanese Primary Prevention Project Clinical Sciences
Conclusions— Aspirin did not show any net benefit for the primary prevention of stroke in elderly Japanese patients with risk factors for stroke, whereas age >70 years, smoking, and diabetes mellitus were risk factors for stroke regardless of aspirin treatment. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00225849.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Uchiyama, S., Ishizuka, N., Shimada, K., Teramoto, T., Yamazaki, T., Oikawa, S., Sugawara, M., Ando, K., Murata, M., Yokoyama, K., Minematsu, K., Matsumoto, M., Ikeda, Y., on behalf of the JPPP Study Group Tags: Cardiovascular Disease, Primary Prevention, Race and Ethnicity, Risk Factors Clinical Sciences Source Type: research

Poststroke agitation and aggression and social quality of life: a case control study.
CONCLUSION: In this study sample, agitation/aggression was preponderantly of the passive type and was associated with poorer HRQoL independently from depression or medical conditions. Patients with both passive and active agitation/aggression had lower Quality of Life (QoL) than patients with only passive agitation/aggression. The causality of the association between low QoL and agitation/aggression needs to be explored in future studies. PMID: 27603431 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - September 6, 2016 Category: Neurology Authors: Lau CG, Tang WK, Liu XX, Liang HJ, Liang Y, Wong A, Mok V, Ungvari GS, Wong KS, Kim JS, Paradiso S Tags: Top Stroke Rehabil Source Type: research

Validation of a Modified CHA2DS2-VASc Score for Stroke Risk Stratification in Asian Patients With Atrial Fibrillation: A Nationwide Cohort Study Clinical Sciences
Conclusions— In this Asian atrial fibrillation cohort, the mCHA2DS2-VASc score performed better than the CHA2DS2-VASc and would further identify atrial fibrillation patients who may derive a positive net clinical benefit from oral anticoagulation.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Chao, T.-F., Lip, G. Y. H., Liu, C.-J., Tuan, T.-C., Chen, S.-J., Wang, K.-L., Lin, Y.-J., Chang, S.-L., Lo, L.-W., Hu, Y.-F., Chen, T.-J., Chiang, C.-E., Chen, S.-A. Tags: Atrial Fibrillation Clinical Sciences Source Type: research

Antiplatelet Strategies and Outcomes in Patients with Noncardioembolic Ischemic Stroke from a Real-World Study with a Five-Year Follow-Up
In conclusion, clopidogrel is suggested for patients with an ESRS >  3 and aspirin for patients with an ESRS ≤ 3 for the secondary prevention of noncardioembolic ischemic stroke in Chinese patients.
Source: Translational Stroke Research - December 30, 2016 Category: Neurology Source Type: research

Gender Differences in Post Stroke Fatigue (P5.290)
Conclusions:In our urban predominately minority cohort, women had more severe PSF than men. The basis for the protective effect of HTN on PSF severity is unclear and deserves further study.Disclosure: Dr. Balucani has nothing to disclose. Dr. Gilles has nothing to disclose. Dr. Singer has nothing to disclose. Dr. Stefanov has nothing to disclose. Dr. Halket has nothing to disclose. Dr. Mlastabi has nothing to disclose. Dr. Huang has nothing to disclose. Dr. Weingast has nothing to disclose. Dr. Levine has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Balucani, C., Gilles, N., Singer, J., Stefanov, D., Halket, D., Mlastabi, J., Huang, A., Weingast, S., Levine, S. Tags: Stroke Recovery and Rehabilitation Source Type: research

Disruption of the Blood-Ocular Barriers in Stroke Patients (S8.008)
Conclusions:GLOS is common in stroke patients regardless of whether they receive treatment. BBB disruption appears to associate with blood-ocular barrier disruption. Whether these findings are due to the acute stroke, or merely due to a common underlying chronic process, remains to be determined.Disclosure: Dr. Hitomi has nothing to disclose. Dr. Latour has nothing to disclose. Dr. Leigh has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Hitomi, E., Latour, L. L., Leigh, R. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Treatment Source Type: research

Factors Mediating Outcome After Stroke: Gender, Thrombolysis, and Their Interaction
AbstractSeveral studies, but not all, have shown that women benefit more from intravenous thrombolysis than men; few have accounted for pre-stroke mobility. Our aim was to determine whether there was an interaction between gender and thrombolysis treatment in 3-month modified Rankin Scale (mRS) score, after adjusting for pre-stroke mobility. We retrospectively reviewed medical records of 1390 consecutive ischemic stroke patients admitted between October 2012 and July 2015. The 3-month mRS was obtained from clinic visits. Thrombolysis-by-gender interaction was evaluated in univariate and multivariate analyses using ordinal ...
Source: Translational Stroke Research - October 24, 2017 Category: Neurology Source Type: research

Very Low Frequency Heart Rate Variability Predicts the Development of Post-Stroke Infections
AbstractStroke-induced immunodepression is a major risk factor for severe infectious complications in the immediate post-stroke period. We investigated the predictive value of heart rate variability (HRV) to identify patients at risk of post-stroke infection, systemic inflammatory response syndrome, or severe sepsis during the post-acute interval from days 3 to 5 after stroke onset. A prospective, observational monocentric cohort study was conducted in a university hospital stroke unit of patients with ischemic infarction in the territory of the middle cerebral artery without an ongoing infection at admission. Standard HRV...
Source: Translational Stroke Research - January 7, 2019 Category: Neurology Source Type: research

CYP2C19 Loss-of-Function Associated with First-Time Ischemic Stroke in Non-surgical Asymptomatic Carotid Artery Stenosis During Clopidogrel Therapy
This study measures effect ofCYP2C19 genotype on ischemic stroke risk during clopidogrel therapy for asymptomatic, extracranial carotid stenosis patients. Using deidentified electronic health records, patients were selected for retrospective cohort using administrative code for carotid stenosis, availability ofCYP2C19 genotype result, clopidogrel exposure, and established patient care. Patients with intracranial atherosclerosis, aneurysm, arteriovenous malformation, prior ischemic stroke, or observation time<1 month were excluded. Dual antiplatelet therapy patients were included. Patients with carotid endarterectomy or ...
Source: Translational Stroke Research - February 21, 2021 Category: Neurology Source Type: research

Outcomes of Thrombolytic Treatment for Acute Ischemic Stroke in Dialysis Dependant Patients in the United States (S02.003)
CONCLUSIONS: The three fold higher odds of in-hospital mortality associated with administration of IV thrombolytics in dialysis dependant patients who present with acute ischemic stroke warrants a careful assessment of risk benefit ratio in this population.Disclosure: Dr. Adil has nothing to disclose. Dr. Adil has nothing to disclose. Dr. Irfan has nothing to disclose. Dr. Chaudhry has nothing to disclose. Dr. ATACH Investigators has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Tariq, N., Adil, M., Irfan, M., Chaudhry, S., Qureshi, A. Tags: S02 Acute Stroke Therapy Source Type: research

Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke Clinical Sciences
Conclusions— In our study, HbA1c turns out to be an important predictor of sICH after thrombolysis for acute stroke. These results suggest that hemorrhage after thrombolysis may be a consequence of long-term vascular injury rather than of acute hyperglycemia, and that HbA1c may be a better predictor than acute blood glucose or a history of diabetes mellitus.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Rocco, A., Heuschmann, P. U., Schellinger, P. D., Kohrmann, M., Diedler, J., Sykora, M., Nolte, C. H., Ringleb, P., Hacke, W., Juttler, E. Tags: Acute Cerebral Infarction, Thrombolysis Clinical Sciences Source Type: research

Differences in Outcome and Predictors Between Ischemic and Intracerebral Hemorrhage: The South London Stroke Register Clinical Sciences
Conclusions— ICH has poorer outcomes up to 5 years after stroke. The improvement of functional outcome up to 3 months was significantly greater with ICH. Identification of factors associated with poor outcome may be used for clinical predictions.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Bhalla, A., Wang, Y., Rudd, A., Wolfe, C. D. A. Tags: Acute Cerebral Hemorrhage, Acute Cerebral Infarction Clinical Sciences Source Type: research

Troponin Elevation Predicts Atrial Fibrillation in Patients with Stroke or Transient Ischemic Attack
Conclusions: cTnI elevation predicts new-onset AF on 24-hour Holter measurement in patients with acute ischemic stroke or TIA and may indicate a poorer prognosis and a higher risk of stroke, MI, and death at 3 months.
Source: Journal of Stroke and Cerebrovascular Diseases - February 17, 2012 Category: Neurology Authors: Isabelle Beaulieu-Boire, Nancy Leblanc, Léo Berger, Jean-Martin Boulanger Tags: Original Articles Source Type: research

Glycosylated Hemoglobin for Diagnosis of Prediabetes in Acute Ischemic Stroke Patients
Background: Prediabetes (PD) is an independent risk factor for stroke. The American Diabetes Association (ADA) has recently published new guidelines recommending glycosylated hemoglobin A1c (HbA1c) as a marker to diagnose diabetes and PD. Diagnosis of diabetes Mellitus (DM) is often made at the time of hospitalization for stroke. Less is known about identifying PD in acute ischemic stroke (AIS) patients. We aim to investigate the frequency of new-onset PD in the hospitalized AIS patients using the new ADA guidelines.Methods: We retrospectively studied 362 AIS patients from our local database. Stroke risk factors, type of s...
Source: Journal of Stroke and Cerebrovascular Diseases - July 19, 2013 Category: Neurology Authors: Branko N. Huisa, Gulmohor Roy, Jorge Kawano, Ronald Schrader Tags: Original Articles Source Type: research

Metformin-inclusive Therapy Reduces the Risk of Stroke in Patients with Diabetes: A 4-Year Follow-up Study
Metformin is a kind of oral hypoglycemic agents commonly prescribed to patients with diabetes mellitus. Although past studies had proven its protective effect on cardiovascular risk and related mortality, the evidence of metformin on stroke prevention was still insufficient and conflicting. Our study randomly selected 14,856 patients with diabetes from the database provided by the Taiwan National Health Research Institute, and 2 cohorts were formulated according to whether metformin was in the prescription record. All cases were followed up for 4 years to track their stroke incidence. As a result, 701 (17.5%) of 3999 diabe...
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2013 Category: Neurology Authors: Yuan-Yang Cheng, Hsin-Bang Leu, Tzeng-Ji Chen, Chen-Ling Chen, Chia-Hua Kuo, Shin-Da Lee, Chung-Lan Kao Tags: Original Articles Source Type: research