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Total 11289 results found since Jan 2013.

A case of Lemierre's syndrome causing panhypopituitarism, cavernous sinus thrombosis, ischaemic stroke and pulmonary embolism
We present the case of a previously well 19-year-old man, who presented acutely unwell with meningitis and sepsis. Fusobacterium necrophorum was isolated from peripheral blood cultures and identified on cerebrospinal fluid with 16S rDNA Polymerase Chain Reaction (PCR). Imaging demonstrated internal jugular vein thrombosis with subsequent cavernous venous sinus thrombosis. Pituitary function tests were suggestive of panhypopituitarism. The patient was diagnosed with Lemierre's syndrome complicated by meningitis, cavernous sinus thrombosis, base of skull osteomyelitis, ischaemic stroke and panhypopituitarism. He was treated ...
Source: Journal of the Royal College of Physicians of Edinburgh - September 7, 2023 Category: General Medicine Authors: Charlotte J Dewdney Joseph J Anderson Simon Dewar Fergus Doubal Frederick R Burgess Deepak Subedi Marcus J Lyall Source Type: research

Role of Iberin as an anti-apoptotic agent on renal ischemia-reperfusion injury in rats
This study aimed to investigate the therapeutic potential of Iberin, known for its anti-inflammatory, antioxidant, and antiapoptotic properties, in a rat model of renal IRI. Twenty-four adult male rats were randomly divided into four groups: Group I (Sham group) underwent laparotomy without IRI induction; Group II (Control group) underwent laparotomy followed by renal artery clamping for 30 minutes to induce ischemia, followed by 2 hours of reperfusion; Group III (Iberin treatment group) received a pre-injection of Iberin (15 mg/kg) and underwent 30 minutes of ischemia followed by 2 hours of reperfusion; and Group IV (Vehi...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Yahiya Ibrahim Yahiya Najah Rayish Hadi Ahmed Abu Raghif Heider Qassam Noor Ghaffar Said Al Habooby Source Type: research

A case of Lemierre's syndrome causing panhypopituitarism, cavernous sinus thrombosis, ischaemic stroke and pulmonary embolism
We present the case of a previously well 19-year-old man, who presented acutely unwell with meningitis and sepsis. Fusobacterium necrophorum was isolated from peripheral blood cultures and identified on cerebrospinal fluid with 16S rDNA Polymerase Chain Reaction (PCR). Imaging demonstrated internal jugular vein thrombosis with subsequent cavernous venous sinus thrombosis. Pituitary function tests were suggestive of panhypopituitarism. The patient was diagnosed with Lemierre's syndrome complicated by meningitis, cavernous sinus thrombosis, base of skull osteomyelitis, ischaemic stroke and panhypopituitarism. He was treated ...
Source: Journal of the Royal College of Physicians of Edinburgh - September 7, 2023 Category: General Medicine Authors: Charlotte J Dewdney Joseph J Anderson Simon Dewar Fergus Doubal Frederick R Burgess Deepak Subedi Marcus J Lyall Source Type: research

Diagnosis and treatment of Watershed strokes: a narrative review
J Med Life. 2023 Jun;16(6):842-850. doi: 10.25122/jml-2023-0127.ABSTRACTWatershed strokes have been described previously as ischemic strokes located in vulnerable border zones between brain tissue supplied by the anterior, posterior, and middle cerebral arteries in the distal junction between two non-anastomotic arterial territories. Ischemic strokes in border zones are well-recognized entities and well-described in terms of imaging features, but the pathophysiological mechanism of brain injury production is not fully defined. Border zone ischemia is caused by cerebral hypoperfusion through decreased cerebral blood flow an...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Oana Andreea Dogariu Ioan Dogariu Corina Maria Vasile Mihaela Corina Berceanu Victor Cornel Raicea Carmen Valeria Albu Ioana Andreea Gheonea Source Type: research

Serum biomarkers to predict hemorrhagic transformation and ischemic stroke outcomes in a prospective cohort study
This study aimed to investigate the potential prognosis role of non-specific laboratory data at admission and baseline MMP-2 and MMP-9 serum levels in predicting HT risk, discharge, and 3-month follow-up status of IS patients. Data from 150 successive acute cerebral infarction patients were analyzed in a prospective cohort study. The active group included patients who developed HT during hospitalization (55 persons). There were no significant differences in age, gender distribution, time to admission, or time to blood sample collection for MMPs measurement between patients in the active and control groups. IS patients from...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Elena Costru-Tasnic Mihail Gavriliuc Elena Manole Source Type: research

Disparities in ethnicity and metabolic disease burden in referrals to nephrology
CONCLUSION: A disproportionately large number of Malay patients are referred for kidney disease. These patients have higher metabolic disease burden, tend to miss appointments and are referred at lower eGFR. Reasons underpinning these associations should be identified to facilitate efforts for targeting this at-risk population, ensuring kidney health for all.PMID:37675684 | DOI:10.4103/singaporemedj.SMJ-2022-193
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Yan Ting Chua Cheang Han Leo Horng Ruey Chua Weng Kin Wong Gek Cher Chan Anantharaman Vathsala Ye Lu Mavis Gan Boon Wee Teo Source Type: research

Role of Iberin as an anti-apoptotic agent on renal ischemia-reperfusion injury in rats
This study aimed to investigate the therapeutic potential of Iberin, known for its anti-inflammatory, antioxidant, and antiapoptotic properties, in a rat model of renal IRI. Twenty-four adult male rats were randomly divided into four groups: Group I (Sham group) underwent laparotomy without IRI induction; Group II (Control group) underwent laparotomy followed by renal artery clamping for 30 minutes to induce ischemia, followed by 2 hours of reperfusion; Group III (Iberin treatment group) received a pre-injection of Iberin (15 mg/kg) and underwent 30 minutes of ischemia followed by 2 hours of reperfusion; and Group IV (Vehi...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Yahiya Ibrahim Yahiya Najah Rayish Hadi Ahmed Abu Raghif Heider Qassam Noor Ghaffar Said Al Habooby Source Type: research

Diagnosis and treatment of Watershed strokes: a narrative review
J Med Life. 2023 Jun;16(6):842-850. doi: 10.25122/jml-2023-0127.ABSTRACTWatershed strokes have been described previously as ischemic strokes located in vulnerable border zones between brain tissue supplied by the anterior, posterior, and middle cerebral arteries in the distal junction between two non-anastomotic arterial territories. Ischemic strokes in border zones are well-recognized entities and well-described in terms of imaging features, but the pathophysiological mechanism of brain injury production is not fully defined. Border zone ischemia is caused by cerebral hypoperfusion through decreased cerebral blood flow an...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Oana Andreea Dogariu Ioan Dogariu Corina Maria Vasile Mihaela Corina Berceanu Victor Cornel Raicea Carmen Valeria Albu Ioana Andreea Gheonea Source Type: research

Role of Iberin as an anti-apoptotic agent on renal ischemia-reperfusion injury in rats
This study aimed to investigate the therapeutic potential of Iberin, known for its anti-inflammatory, antioxidant, and antiapoptotic properties, in a rat model of renal IRI. Twenty-four adult male rats were randomly divided into four groups: Group I (Sham group) underwent laparotomy without IRI induction; Group II (Control group) underwent laparotomy followed by renal artery clamping for 30 minutes to induce ischemia, followed by 2 hours of reperfusion; Group III (Iberin treatment group) received a pre-injection of Iberin (15 mg/kg) and underwent 30 minutes of ischemia followed by 2 hours of reperfusion; and Group IV (Vehi...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Yahiya Ibrahim Yahiya Najah Rayish Hadi Ahmed Abu Raghif Heider Qassam Noor Ghaffar Said Al Habooby Source Type: research

Serum biomarkers to predict hemorrhagic transformation and ischemic stroke outcomes in a prospective cohort study
This study aimed to investigate the potential prognosis role of non-specific laboratory data at admission and baseline MMP-2 and MMP-9 serum levels in predicting HT risk, discharge, and 3-month follow-up status of IS patients. Data from 150 successive acute cerebral infarction patients were analyzed in a prospective cohort study. The active group included patients who developed HT during hospitalization (55 persons). There were no significant differences in age, gender distribution, time to admission, or time to blood sample collection for MMPs measurement between patients in the active and control groups. IS patients from...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Elena Costru-Tasnic Mihail Gavriliuc Elena Manole Source Type: research

Diagnosis and treatment of Watershed strokes: a narrative review
J Med Life. 2023 Jun;16(6):842-850. doi: 10.25122/jml-2023-0127.ABSTRACTWatershed strokes have been described previously as ischemic strokes located in vulnerable border zones between brain tissue supplied by the anterior, posterior, and middle cerebral arteries in the distal junction between two non-anastomotic arterial territories. Ischemic strokes in border zones are well-recognized entities and well-described in terms of imaging features, but the pathophysiological mechanism of brain injury production is not fully defined. Border zone ischemia is caused by cerebral hypoperfusion through decreased cerebral blood flow an...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Oana Andreea Dogariu Ioan Dogariu Corina Maria Vasile Mihaela Corina Berceanu Victor Cornel Raicea Carmen Valeria Albu Ioana Andreea Gheonea Source Type: research

Serum biomarkers to predict hemorrhagic transformation and ischemic stroke outcomes in a prospective cohort study
This study aimed to investigate the potential prognosis role of non-specific laboratory data at admission and baseline MMP-2 and MMP-9 serum levels in predicting HT risk, discharge, and 3-month follow-up status of IS patients. Data from 150 successive acute cerebral infarction patients were analyzed in a prospective cohort study. The active group included patients who developed HT during hospitalization (55 persons). There were no significant differences in age, gender distribution, time to admission, or time to blood sample collection for MMPs measurement between patients in the active and control groups. IS patients from...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Elena Costru-Tasnic Mihail Gavriliuc Elena Manole Source Type: research

A case of Lemierre's syndrome causing panhypopituitarism, cavernous sinus thrombosis, ischaemic stroke and pulmonary embolism
We present the case of a previously well 19-year-old man, who presented acutely unwell with meningitis and sepsis. Fusobacterium necrophorum was isolated from peripheral blood cultures and identified on cerebrospinal fluid with 16S rDNA Polymerase Chain Reaction (PCR). Imaging demonstrated internal jugular vein thrombosis with subsequent cavernous venous sinus thrombosis. Pituitary function tests were suggestive of panhypopituitarism. The patient was diagnosed with Lemierre's syndrome complicated by meningitis, cavernous sinus thrombosis, base of skull osteomyelitis, ischaemic stroke and panhypopituitarism. He was treated ...
Source: Journal of the Royal College of Physicians of Edinburgh - September 7, 2023 Category: General Medicine Authors: Charlotte J Dewdney Joseph J Anderson Simon Dewar Fergus Doubal Frederick R Burgess Deepak Subedi Marcus J Lyall Source Type: research

Association of baseline fasting plasma glucose with 1-year mortality in non-diabetic patients with acute cerebral infarction: a multicentre observational cohort study
Conclusion In non-diabetic patients with ACI, elevated baseline FPG is an independent risk factor for 1-year all-cause mortality, and the two are positively and non-linearly associated. These results suggest that high FPG should be seen as a concern in non-diabetic patients with ACI.
Source: BMJ Open - September 6, 2023 Category: General Medicine Authors: Zhang, D., Liu, Z., Liu, P., Zhang, H., Guo, W., Lu, Q., Huang, C., Wang, J., Chang, Q., Zhang, M., Huo, Y., Wang, Y., Lin, X., Wang, F., Wu, S. Tags: Open access, Neurology Source Type: research

Association between diseases of despair and atherosclerotic cardiovascular disease among insured adults in the USA: a retrospective cohort study from 2017 to 2021
Conclusions Among this cohort of insured adults, documented DoD was associated with increased ASCVD risk. Further research to understand and address cardiovascular disease prevention in those with DoD could reduce costs, morbidity and mortality. Further examination of overlapping structural factors that may be contributing to concurrent rises in ASCVD and DoD in the USA is needed.
Source: BMJ Open - September 6, 2023 Category: General Medicine Authors: Nudy, M., Galper, K., George, D. R., Williams, B. A., Kraschnewski, J. L., Sinoway, L., Brignone, E. Tags: Open access, Cardiovascular medicine Source Type: research