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Total 60 results found since Jan 2013.
Improving outcomes in intracerebral hemorrhage through microglia/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes
Biomaterials. 2023 Aug 15;301:122277. doi: 10.1016/j.biomaterials.2023.122277. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) remains the most lethal type of stroke, and effective clinical therapies that can speed up hematoma resolution after ICH are still lacking. While the beneficial effects of IL-10 on ICH recovery have been demonstrated, the clinical translation of IL-10 requires effective delivery methods by which sufficient IL-10 can be delivered to ICH-affected regions in the brain. Here we report the use of a phosphatidylserine (PS) liposome (PSL)-based nanoparticle system for microglia/macrophage-tar...
Source: Biomaterials - August 19, 2023 Category: Materials Science Authors: Ranran Han Xi Lan Zheng Han Honglei Ren Safiya Aafreen Wenshen Wang Zhipeng Hou Tianyue Zhu Andrew Qian Xiaoning Han Raymond C Koehler Guanshu Liu Source Type: research
The potential role of the novel orodispersible film from rice polymer loaded with silkworm pupae hydrolysate and the combined extract of holy basil and ginger for the management of stroke with stress
In this study, we explored the neuroprotective effect of an orodispersible film derived from a rice polymer loaded with silkworm pupae and the combined extract of holy basil and ginger (JP1). Male Wistar rats weighing 200-250 g were administered JP1 at the doses of 1, 10, and 100 mg/kg BW 45 min prior to an exposure to a 6-h immobilization stress for 14 days. Permanent, occlusion of the right middle cerebral artery (MCAO) was performed, and JP1 was administered continually for 21 days after MCAO. Assessments of the brain infarction volume, oxidative stress, inflammation, and apoptosis in the cerebral cortex were carried ou...
Source: Biomaterials - June 1, 2023 Category: Materials Science Authors: Putthiwat Thongwong Jintanaporn Wattanathorn Wipawee Thukhammee Somsak Tiamkao Source Type: research
A new insight into the mechanical properties of nanobiofibers and vibrational behavior of atomic force microscope beam considering them as the samples
J Mech Behav Biomed Mater. 2023 Apr 5;142:105842. doi: 10.1016/j.jmbbm.2023.105842. Online ahead of print.ABSTRACTNowadays, the utilization and production of polymeric nanofibers are expanding rapidly due to their unique and exclusive properties. The current study examined silk fibroin nanofibers, poly-L lactic acid (PLLA), and polycaprolactone (PCL) as three widely-used biopolymers. In the first section, the mechanical properties of nanobiofibers, including elastic modulus as the first research variable, were investigated using atomic force microscopy (AFM)-based nanoindentation and tensile testing (through a universal te...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 9, 2023 Category: Materials Science Authors: Ali Jafari Ali Sadeghi Source Type: research
The influence of blood composition and loading frequency on the behavior of embolus analogs
J Mech Behav Biomed Mater. 2023 Feb 18;140:105738. doi: 10.1016/j.jmbbm.2023.105738. Online ahead of print.ABSTRACTIn cases of acute ischemic stroke (AIS), mechanical thrombectomy (MT) can be used to directly remove lodged thromboemboli. Despite improvements in patient outcomes, one of the key factors affecting MT success is the mechanical properties of the occlusive thrombus. Therefore, the goal of this study was to investigate the viscoelastic properties of embolus analogs (EAs) and determine the influence of EA hematocrit and loading frequency. Bovine blood EAs were created over a range of physiological hematocrits (0-6...
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 23, 2023 Category: Materials Science Authors: Bryan C Good Source Type: research
Is the optimal Tmax threshold identifying perfusion deficit volumes variable across MR perfusion software packages? A pilot study
ConclusionsThe optimal Tmax threshold for defining the ischemic penumbra appeared to be most accurate at ≥ 6 s for package A and ≥ 10 s for package B. This implies that the widely recommended Tmax threshold ≥ 6 s may not be optimal for all available MRP software package. Future validation studies are required to define the optimal Tmax threshold to use for each package.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - February 22, 2023 Category: Materials Science Source Type: research
Crafting ɣ-L-Glutamyl-l-Cysteine layered Human Serum Albumin-nanoconstructs for brain targeted delivery of ropinirole to attenuate cerebral ischemia/reperfusion injury via "3A approach"
Biomaterials. 2022 Sep 15;289:121805. doi: 10.1016/j.biomaterials.2022.121805. Online ahead of print.ABSTRACTTreatment of Ischemic Stroke is inordinately challenging due to its complex aetiology and constraints in shuttling therapeutics across blood-brain barrier. Ropinirole hydrochloride (Rp), a propitious neuroprotectant with anti-oxidant, anti-inflammatory, and anti-apoptotic properties (3A) is repurposed for remedying ischemic stroke and reperfusion (I/R) injury. The drug's low bioavailability in brain however, limits its therapeutic efficacy. The current research work has reported sub-100 nm gamma-L-Glutamyl-L-Cystein...
Source: Biomaterials - September 26, 2022 Category: Materials Science Authors: Saman Fatima Mubashshir Ali Syed Naved Quadri Sarwar Beg M Samim Suhel Parvez Malik Zainul Abdin Prashant Mishra Farhan Jalees Ahmad Source Type: research
Combined stent-retriever and aspiration intra-arterial thrombectomy performance for fragmentable blood clots: A proof-of-concept computational study
This study focuses on two aspects of the thrombectomy simulation: i) Thrombus fragmentation on the basis of a failure model calibrated with experimental tests on clot analogs; ii) the combined stent-retriever and aspiration catheter MT procedure is modeled by adding both the proximal balloon guide catheter and the distal access catheter. The adopted failure criterion is based on maximum principal stress threshold value. If elements of the thrombus exceed this criterion during the retrieval simulation, then they are deleted from the calculation. Comparison with in-vitro tests indicates that the simulation correctly reproduc...
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 18, 2022 Category: Materials Science Authors: Giulia Luraghi Sara Bridio Vittorio Lissoni Gabriele Dubini Anushree Dwivedi Ray McCarthy Behrooz Fereidoonnezhad Patrick McGarry Frank J H Gijsen Jose Felix Rodriguez Matas Francesco Migliavacca Source Type: research
Patient-specific biomechanical analysis of atherosclerotic plaques enabled by histologically validated tissue characterization from computed tomography angiography: A case study
CONCLUSION: Patient specific tissue characterization can identify distributions of stress and strain in a clinically relevant range. This capability may be used to identify high-risk lesions and personalize treatment decisions for individual patients with cardiovascular disease and improve prevention of myocardial infarction and stroke.PMID:36049368 | DOI:10.1016/j.jmbbm.2022.105403
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 1, 2022 Category: Materials Science Authors: Andrew J Buckler Max van Wanrooij M åns Andersson Eva Karl öf Ljubica Perisic Matic Ulf Hedin T Christian Gasser Source Type: research
A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks
Biomaterials. 2022 Aug 15:121729. doi: 10.1016/j.biomaterials.2022.121729. Online ahead of print.ABSTRACTBrain arteriovenous malformations (AVMs) are a disorder wherein abnormal, enlarged blood vessels connect arteries directly to veins, without an intervening capillary bed. AVMs are one of the leading causes of hemorrhagic stroke in children and young adults. Most human sporadic brain AVMs are associated with genetic activating mutations in the KRAS gene. Our goal was to develop an in vitro model that would allow for simultaneous morphological and functional phenotypic data capture in real time during AVM disease progress...
Source: Biomaterials - August 23, 2022 Category: Materials Science Authors: Kayla Soon Mengyuan Li Ruilin Wu Angela Zhou Negar Khosraviani Williamson D Turner Joshua D Wythe Jason E Fish Sara S Nunes Source Type: research
