Filtered By:
Specialty: Materials Science
Condition: Ischemic Stroke
This page shows you your search results in order of date.
Order by Relevance | Date
Total 45 results found since Jan 2013.
The potential role of the novel orodispersible film from rice polymer loaded with silkworm pupae hydrolysate and the combined extract of holy basil and ginger for the management of stroke with stress
In this study, we explored the neuroprotective effect of an orodispersible film derived from a rice polymer loaded with silkworm pupae and the combined extract of holy basil and ginger (JP1). Male Wistar rats weighing 200-250 g were administered JP1 at the doses of 1, 10, and 100 mg/kg BW 45 min prior to an exposure to a 6-h immobilization stress for 14 days. Permanent, occlusion of the right middle cerebral artery (MCAO) was performed, and JP1 was administered continually for 21 days after MCAO. Assessments of the brain infarction volume, oxidative stress, inflammation, and apoptosis in the cerebral cortex were carried ou...
Source: Biomaterials - June 1, 2023 Category: Materials Science Authors: Putthiwat Thongwong Jintanaporn Wattanathorn Wipawee Thukhammee Somsak Tiamkao Source Type: research
The influence of blood composition and loading frequency on the behavior of embolus analogs
J Mech Behav Biomed Mater. 2023 Feb 18;140:105738. doi: 10.1016/j.jmbbm.2023.105738. Online ahead of print.ABSTRACTIn cases of acute ischemic stroke (AIS), mechanical thrombectomy (MT) can be used to directly remove lodged thromboemboli. Despite improvements in patient outcomes, one of the key factors affecting MT success is the mechanical properties of the occlusive thrombus. Therefore, the goal of this study was to investigate the viscoelastic properties of embolus analogs (EAs) and determine the influence of EA hematocrit and loading frequency. Bovine blood EAs were created over a range of physiological hematocrits (0-6...
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 23, 2023 Category: Materials Science Authors: Bryan C Good Source Type: research
Is the optimal Tmax threshold identifying perfusion deficit volumes variable across MR perfusion software packages? A pilot study
ConclusionsThe optimal Tmax threshold for defining the ischemic penumbra appeared to be most accurate at ≥ 6 s for package A and ≥ 10 s for package B. This implies that the widely recommended Tmax threshold ≥ 6 s may not be optimal for all available MRP software package. Future validation studies are required to define the optimal Tmax threshold to use for each package.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - February 22, 2023 Category: Materials Science Source Type: research
Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane
Biomaterials. 2022 Dec 23;293:121983. doi: 10.1016/j.biomaterials.2022.121983. Online ahead of print.ABSTRACTThe basement membrane (BM) of the blood-brain barrier (BBB), a thin extracellular matrix (ECM) sheet underneath the brain microvascular endothelial cells (BMECs), plays crucial roles in regulating the unique physiological barrier function of the BBB, which represents a major obstacle for brain drug delivery. Owing to the difficulty in mimicking the unique biophysical and chemical features of BM in in vitro systems, current in vitro BBB models have suffered from poor physiological relevance. Here, we describe a highl...
Source: Biomaterials - January 7, 2023 Category: Materials Science Authors: Jeong-Won Choi Jaeseung Youn Dong Sung Kim Tae-Eun Park Source Type: research
A low dimensional surrogate model for a fast estimation of strain in the thrombus during a thrombectomy procedure
CONCLUSIONS: The surrogate model provides nearly instantaneous estimates and constitutes a valuable tool for evaluating the risk of thrombus rupture during pre-operative planning for the treatment of acute ischemic stroke.PMID:36410165 | DOI:10.1016/j.jmbbm.2022.105577
Source: Journal of the Mechanical Behavior of Biomedical Materials - November 21, 2022 Category: Materials Science Authors: Sara Bridio Giulia Luraghi Francesco Migliavacca Sanjay Pant Alberto Garc ía-González Jose F Rodriguez Matas Source Type: research
Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke
Biomaterials. 2022 Nov 10;291:121904. doi: 10.1016/j.biomaterials.2022.121904. Online ahead of print.ABSTRACTOxidative stress and mitochondrial damage are the main mechanisms of ischemia-reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free radical scavenging ability were used as carriers to load dl-3-n-butylphthalide (NBP-CeO2 NPs) for the combined treatment of ischemic stroke. NBP-CeO2 NPs could eliminate reactive oxygen species (ROS) in mouse brain microvascular endothelial cells and hippocampal neurons after oxygen-glucose deprivation/reoxygenation (OGD/R), and also save mitochond...
Source: Biomaterials - November 20, 2022 Category: Materials Science Authors: Xiang Li Zhihui Han Tianyi Wang Cheng Ma Haiying Li Huali Lei Yuqi Yang Yuanjie Wang Zifan Pei Zhuang Liu Liang Cheng Gang Chen Source Type: research
Crafting ɣ-L-Glutamyl-l-Cysteine layered Human Serum Albumin-nanoconstructs for brain targeted delivery of ropinirole to attenuate cerebral ischemia/reperfusion injury via "3A approach"
Biomaterials. 2022 Sep 15;289:121805. doi: 10.1016/j.biomaterials.2022.121805. Online ahead of print.ABSTRACTTreatment of Ischemic Stroke is inordinately challenging due to its complex aetiology and constraints in shuttling therapeutics across blood-brain barrier. Ropinirole hydrochloride (Rp), a propitious neuroprotectant with anti-oxidant, anti-inflammatory, and anti-apoptotic properties (3A) is repurposed for remedying ischemic stroke and reperfusion (I/R) injury. The drug's low bioavailability in brain however, limits its therapeutic efficacy. The current research work has reported sub-100 nm gamma-L-Glutamyl-L-Cystein...
Source: Biomaterials - September 26, 2022 Category: Materials Science Authors: Saman Fatima Mubashshir Ali Syed Naved Quadri Sarwar Beg M Samim Suhel Parvez Malik Zainul Abdin Prashant Mishra Farhan Jalees Ahmad Source Type: research
ASAP Correction to “A Co-Doped Fe < sub > 3 < /sub > O < sub > 4 < /sub > Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic Stroke ”
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c12150
Source: ACS Applied Materials and Interfaces - September 19, 2022 Category: Materials Science Authors: Yunsheng Liu, Xiaojun Wang, Xiangzhu Li, Shanshan Qiao, Guodong Huang, Dirk Matthias Hermann, Thorsten Roland Doeppner, Muling Zeng, Wei Liu, Gelin Xu, Lijie Ren, Yuan Zhang, Wenlan Liu, Eudald Casals, Weiping Li, and Ya-Chao Wang Source Type: research
Combined stent-retriever and aspiration intra-arterial thrombectomy performance for fragmentable blood clots: A proof-of-concept computational study
This study focuses on two aspects of the thrombectomy simulation: i) Thrombus fragmentation on the basis of a failure model calibrated with experimental tests on clot analogs; ii) the combined stent-retriever and aspiration catheter MT procedure is modeled by adding both the proximal balloon guide catheter and the distal access catheter. The adopted failure criterion is based on maximum principal stress threshold value. If elements of the thrombus exceed this criterion during the retrieval simulation, then they are deleted from the calculation. Comparison with in-vitro tests indicates that the simulation correctly reproduc...
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 18, 2022 Category: Materials Science Authors: Giulia Luraghi Sara Bridio Vittorio Lissoni Gabriele Dubini Anushree Dwivedi Ray McCarthy Behrooz Fereidoonnezhad Patrick McGarry Frank J H Gijsen Jose Felix Rodriguez Matas Francesco Migliavacca Source Type: research
