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Sensors ‐based monitoring and treatment approaches for in‐stent restenosis
AbstractCardiovascular disease (CVD) can progressively narrow arteries due to plaque accumulation on the inner walls of the blood vessels, which results in an obstructed blood flow, leading to heart attack, stroke, and even death if the obstruction is severe. A popular treatment for the disease is to use an intravascular mechanical device called the stent to achieve an immediate restoration of blood flow. However, the physical stimulation induced by the stent expansion can cause inflammation of the vessel tissue. As one of the most common post-stenting complications, re-narrowing of the vessel is the main pathology that le...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 26, 2022 Category: Materials Science Authors: Ying Yi, Bo Wang, Changping Li Tags: REVIEW ARTICLE Source Type: research

Patient-specific biomechanical analysis of atherosclerotic plaques enabled by histologically validated tissue characterization from computed tomography angiography: A case study
CONCLUSION: Patient specific tissue characterization can identify distributions of stress and strain in a clinically relevant range. This capability may be used to identify high-risk lesions and personalize treatment decisions for individual patients with cardiovascular disease and improve prevention of myocardial infarction and stroke.PMID:36049368 | DOI:10.1016/j.jmbbm.2022.105403
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 1, 2022 Category: Materials Science Authors: Andrew J Buckler Max van Wanrooij M åns Andersson Eva Karl öf Ljubica Perisic Matic Ulf Hedin T Christian Gasser Source Type: research

Development of next generation cardiovascular therapeutics through bio ‐assisted nanotechnology
Abstract Cardiovascular diseases (CVDs) rank, next to cancer and stroke, among the deadliest diseases in the world. Among the major CVDs, acute myocardial infarction is a life‐threatening disorder resulting from permanent damage to the left ventricular cardiac tissue. The major coronary arteries that supply blood to the functional left ventricle become blocked due to thrombotic plaque occlusion. During myocardial ischemia, oxidative stress and free radicals destroy healthy cardiomyocytes, smooth muscle cells, and endothelial cells, followed by degradation of the extracellular matrix, which results in ventricular wall‐t...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 26, 2017 Category: Materials Science Authors: Rajesh Lakshmanan, Nilanjana Maulik Tags: Review Article Source Type: research

Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury.
Abstract Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Riegler J, Liew A, Hynes SO, Ortega D, O'Brien T, Day RM, Richards T, Sharif F, Pankhurst QA, Lythgoe MF Tags: Biomaterials Source Type: research