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When does life end? New organ donation strategy fuels debate
On a chilly holiday Monday in January 2020, a medical milestone passed largely unnoticed. In a New York City operating room, surgeons gently removed the heart from a 43-year-old man who had died and shuttled it steps away to a patient in desperate need of a new one. More than 3500 people in the United States receive a new heart each year. But this case was different—the first of its kind in the country. “It took us 6 months to prepare,” says Nader Moazami, surgical head of heart transplantation at New York University (NYU) Langone Health, where the operation took place. The run-up included oversight from an ethi...
Source: ScienceNOW - May 11, 2023 Category: Science Source Type: news

Factors affecting organ donation rate during devastating brain injuries: A 6-year data analysis.
Conclusions: Our findings showed that refusal by the family was the most common reason for failure of deceased organ donations. To maximize the number of procured organs, transplant communities need to focus on increasing awareness regarding brain death and organ donation and establish strategies to increase consent obtained from the families. PMID: 31903853 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - January 8, 2020 Category: Surgery Tags: Acta Chir Belg Source Type: research

Analysis of factors involved in brain-death donor processing for face transplantation in Korea: How much time is available from brain death to transplantation?
Conclusions: When face transplantation is performed, the transplantation team has 22 hours 57 minutes on average to prepare after the first brain death decision. The cause of brain death was head trauma in approximately one-fourth of cases. Although head trauma does not always imply facial trauma, surgeons should be aware that the facial tissue may be compromised in such cases. PMID: 31462025 [PubMed - as supplied by publisher]
Source: Archives of Plastic Surgery - August 30, 2019 Category: Cosmetic Surgery Tags: Arch Plast Surg Source Type: research

Effects of Normothermic Machine Perfusion Conditions on Mesenchymal Stromal Cells
In this study the effect of NMP perfusion fluid on survival, metabolism and function of thawed cryopreserved human (h)MSC and porcine (p)MSC in suspension conditions was studied. Suspension conditions reduced the viability of pMSC by 40% in both perfusion fluid and culture medium. Viability of hMSC was reduced by suspension conditions by 15% in perfusion fluid, whilst no differences were found in survival in culture medium. Under adherent conditions, survival of the cells was not affected by perfusion fluid. The perfusion fluid did not affect survival of fresh MSC in suspension compared to the control culture medium. The f...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Organ donation: the reality of an intensive care unit in Portugal
Conclusion: In most cases, potential organ donors died of brain death, were older than middle age, were male and were victims of a hemorrhagic stroke. The majority of the donors were expanded criteria donors and donated an average of two to three organs. The organs donated most frequently were the kidneys and liver.
Source: Revista Brasileira de Terapia Intensiva - July 11, 2018 Category: Intensive Care Source Type: research

Brain Death Determination - a dataset analysis in Parana State Between 2013-2015 (P6.053)
Conclusions:We observed that there were marked delays between brain death suspicion and beginning the determination (~25 hrs), especially when CNS depressant drugs were used (+ 44 hrs), as well as and during BDD (~23 hrs), which can reduce the number of effective donors and viable organs available.Disclosure: Dr. Caeira has nothing to disclose. Dr. Germiniani has nothing to disclose. Dr. Rodrigues has nothing to disclose. Dr. Silvado has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Caeira, M., Germiniani, F., Rodrigues, J., Silvado, C. Tags: Neurocritical Care: Brain Death/Organ Donation Source Type: research

Non-therapeutic intensive care for organ donation: A healthcare professionals' opinion survey.
CONCLUSION: The acceptance by healthcare professionals of non-therapeutic intensive care for brain death organ donation seems fairly good, despite a suboptimal education regarding brain death, non-therapeutic intensive care and families' support. But they ask to require previously expressed patient's consent and family's approval. So, it seems that non-therapeutic intensive care should only remain an ethically sound mean of empowerment of organ donors and their families to make post-mortem donation happen as a full respect of individual autonomy. PMID: 25488762 [PubMed - as supplied by publisher]
Source: Nursing Ethics - December 8, 2014 Category: Nursing Authors: Camut S, Baumann A, Dubois V, Ducrocq X, Audibert G Tags: Nurs Ethics Source Type: research

Using Drug-Intoxicated Deaths as Potential Organ Donors: Impression of Attendees at the American College of Medical Toxicology 2014 Annual Scientific Meeting.
CONCLUSIONS: Medical toxicologists have some reservation in recommending solid organs for transplantation from deaths from cocaine and carbon monoxide. Given the decrease in potential organ donors from typical methods of death, further work is needed to promote organ donation in deaths related to acute poisoning. PMID: 25023224 [PubMed - as supplied by publisher]
Source: Journal of Medical Toxicology - July 15, 2014 Category: Toxicology Authors: Wood DM, Chan WL, Dargan PI Tags: J Med Toxicol Source Type: research