• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Structural racism and racial health disparities at the state level: A latent variable approach
Conclusions This research provides further evidence that structural racism is a fundamental cause of racial health disparities and that to repair these inequities, macro-level changes in societal structures, institutions, resource allocation, representation, and power will be necessary.PMID:37500328 | DOI:10.1016/j.jnma.2023.07.003
Source: Journal of the National Medical Association - July 27, 2023 Category: General Medicine Authors: Michael Siegel Madeline Rieders Hannah Rieders Jinan Moumneh Julia Asfour Jinseo Oh Seungjin Oh Source Type: research

Carbon dioxide flooding to reduce postoperative neurological injury following surgery for acute type A aortic dissection: a prospective, randomised, blinded, controlled clinical trial, CARTA study protocol - objectives and design
This report describes the objectives and design of the CARTA trial, investigating whether carbon dioxide flooding reduces neurological injury following surgery for ATAAD. Methods and analysis The CARTA trial is a single-centre, prospective, randomised, blinded, controlled clinical trial of ATAAD surgery with carbon dioxide flooding of the surgical field. Eighty consecutive patients undergoing repair of ATAAD, and who do not have previous neurological injuries or ongoing neurological symptoms, will be randomised (1:1) to either receive carbon dioxide flooding of the surgical field or not. Routine repair will be performed r...
Source: BMJ Open - May 25, 2023 Category: General Medicine Authors: Ede, J., Teurneau-Hermansson, K., Moseby-Knappe, M., Ramgren, B., Bjursten, H., Ederoth, P., Larsson, M., Mattsson-Carlgren, N., Sjögren, J., Wierup, P., Nozohoor, S., Zindovic, I. Tags: Open access, Cardiovascular medicine Source Type: research

Surgical implementation gap: an interrupted time series analysis with interviews examining the impact of surgical trials on surgical practice in England
Conclusion While practice does not always change in the direction indicated by clinical trials, our results suggest that individuals, official committees and professional societies do assimilate trial evidence. Decision-makers seem to respond to the totality of evidence such that there are often plausible reasons for not adopting the evidence of any one trial in isolation.
Source: BMJ Quality and Safety - May 18, 2023 Category: General Medicine Authors: Schmidtke, K. A., Evison, F., Grove, A., Kudrna, L., Tucker, O., Metcalfe, A., Bradbury, A. W., Bhangu, A., Lilford, R. Tags: Open access, Editor's choice Original research Source Type: research

Carbon dioxide flushing versus saline flushing of thoracic aortic stents (INTERCEPTevar): protocol for a multicentre pilot randomised controlled trial
Introduction Thoracic endovascular aortic repair (TEVAR) carries a 3%–6.1% stroke risk, including risk of ‘silent’ cerebral infarction (SCI). Stent-grafts are manufactured in room air and retain air. Instructions for use recommend saline flushing to ‘de-air’ the system prior to insertion, but substantial amounts of air are released when deploying them, potentially leading to downstream neuronal injury and SCI. Carbon dioxide (CO2) is more dense and more soluble in blood than air, without risk of bubble formation, so could be used in addition to saline to de-air stents. This pilot trial aims to...
Source: BMJ Open - April 27, 2023 Category: General Medicine Authors: Crockett, S., Hanna, L., Singh, A., Gunning, S., Nicholas, R., Bicknell, C., Hamady, M., Gable, D., Sallam, M., Modarai, B., Abisi, S., Lyons, O., Gibbs, R. Tags: Open access, Surgery Source Type: research

Aortic arch surgery for type B aortic dissection: How far should we go? The value of a hybrid approach
Surgical treatment for aortic disease remains challenging and demanding. Treatment often needs to be tailored to the patient or the group of patients being referred. A hybrid approach may have a role to play as an additional option to the surgical armamentarium. Cooperation between different specialists is essential. AbstractTraditionally, the management of type B aortic dissection has been the domain of the vascular surgeons. Timing and type of intervention still generate debate. We sought to review our early experience with the treatment of this condition based on a hybrid approach following an aortic multi-disciplinary ...
Source: Clinical Case Reports - January 4, 2023 Category: General Medicine Authors: Massimo Capoccia, Mohamed Ashur Sherif, Ahmed Nassef, David Shaw, Paul Walker, Betsy Evans, Pankaj Kaul, Walid Elmahdy Tags: CASE REPORT Source Type: research

Network pharmacology and molecular docking analysis on molecular targets and mechanisms of < em > Gastrodia  elata < /em > Blume in the treatment of ischemic stroke
Exp Ther Med. 2022 Nov 3;24(6):742. doi: 10.3892/etm.2022.11678. eCollection 2022 Dec.ABSTRACTGastrodia elata Blume (GEB) is widely used to treat cardio-cerebrovascular disease in China and in traditional Chinese medicine it is considered to be a dispelling wind and dredging collateral. However, the mechanism and active components of the plant in treating ischemic stroke (IS) remain unclear. The present study aimed to identify the active components and mechanism of GEB in treating IS using network pharmacology and molecular docking technology. Network analysis predicted 752 potential targets from 14 compounds in GEB, shari...
Source: Experimental and Therapeutic Medicine - December 26, 2022 Category: General Medicine Authors: Yuan Luo Pu Chen Liping Yang Xiaohua Duan Source Type: research

Pages: 1  2  3  4  5