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Total 141 results found since Jan 2013.

Evaluation After a First Seizure in Adults
Am Fam Physician. 2022 May 1;105(5):507-513.ABSTRACTSeizures are transient signs and symptoms of abnormal, excessive, or synchronous neuronal activity in the brain. Up to 10% of adults have a seizure during their lifetime, with increasing incidence in people older than 55 years. One-third of people have a recurrent seizure within one year of an initial unprovoked seizure. Acute symptomatic (provoked) seizures recur less often, especially when provoking factors are addressed. After confirming a probable seizure, evaluation focuses on identifying provoking factors such as tumor, metabolic derangement, infectious disease, str...
Source: American Family Physician - May 13, 2022 Category: Primary Care Authors: Kate Rowland Carl Earl Lambert Source Type: research

Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology
ConclusionThe computational modeling approach provides ability to conduct in silico trials representative of CSF injection protocols. Taken together, the findings indicate a strong potential for delivery protocols to be optimized to reach a target region(s) of the spine and/or brain with a needed therapeutic dose. Parametric modification of bolus rate/volume and flush volume was found to have impact on tracer distribution; albeit to a smaller degree than injection location, with CM and ICV injections resulting in greater therapeutic dose to brain regions compared to LP. CSF stroke volume and frequency both played an import...
Source: Fluids and Barriers of the CNS - January 28, 2022 Category: Neuroscience Source Type: research

Cerebral venous thrombosis revealing neurosyphilis
CONCLUSION: Cerebral venous thrombosis in neurosyphilis is a poorly described entity. This case report confirms the status of great simulator of syphilis. In the context of its worldwide recrudescence, syphilis must be evoked in front of an unexplained neurological disorder.PMID:34863597 | DOI:10.1016/j.revmed.2021.11.001
Source: Revue de Medecine Interne - December 5, 2021 Category: Internal Medicine Authors: O Chol S Gallet L Bouillet G Besson H Kholi Source Type: research