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Current management of post-varicella stroke in children: A literature review.
Abstract Among infectious factors, varicella-zoster virus (VZV) is a leading cause of central nervous system vasculopathy and stroke in childhood. Not only have viral markers been detected in the cerebrospinal fluid of affected patients, but also direct evidence of viral particles in the wall of cerebral arteries has been demonstrated in rare pathological specimens. This certainly reflects a localized infectious process likely associated with variable indirect inflammatory responses. Yet the usefulness in this setting of a lumbar puncture as well as of subsequent targeted antiviral and/or anti-inflammatory therapi...
Source: Archives de Pediatrie - July 6, 2013 Category: Pediatrics Authors: Monteventi O, Chabrier S, Fluss J Tags: Arch Pediatr Source Type: research

Yield of Cather Angiography After Computed Tomography Negative, Lumbar Puncture Positive Subarachnoid Hemorrhage Brief Reports
Conclusions— Catheter angiography should be performed in patients with computed tomography negative but suspicious lumbar puncture, particularly in the presence of xanthochromia. The benefit of angiography in patients with erythrocytosis only is unclear and deserves future study.
Source: Stroke - May 24, 2013 Category: Neurology Authors: Wallace, A. N., Dines, J. N., Zipfel, G. J., Derdeyn, C. P. Tags: CT and MRI, Angiography Brief Reports Source Type: research

Idiopathic intracranial hypertension associated with iron-deficiency anaemia
A 12-year-old Nigerian girl presented to the Emergency Department with headache, dizziness and diplopia. She had a history of menorrhagia. Mild dyspnoea, tachycardia, left sixth cranial nerve palsy and papilloedema (figures 1 and 2) were noted. Body mass index was normal. Full blood count revealed haemoglobin of 4.8 g/dl. The red cells were hypochromic and mircocytic. A CT scan of the brain with venous contrast was normal. A lumbar puncture showed opening and closing pressures of 35 and 33.5 cm H2O, respectively. The diagnosis of idiopathic intracranial hypertension secondary to iron-deficiency anaemia was made. ...
Source: Archives of Disease in Childhood - May 9, 2013 Category: Pediatrics Authors: Forman, E. B., O'Byrne, J. J., Capra, L., McElnea, E., King, M. D. Tags: Miscellanea Source Type: research

Effects of Intravenous Solanezumab 400 mg q 4 Weeks vs. Placebo on Biomarkers in Patients with Mild to Moderate Alzheimer's Disease: Results of Two Phase 3 Studies (P01.011)
CONCLUSIONS: Solanezumab target engagement is associated with alteration of amyloid biology. There was a lack of apparent effect on markers of neurodegeneration. The overall findings lend support for the amyloid cascade hypothesis and suggest that various aspects of the cascade are viable targets for treatment of Alzheimer's disease.Supported by: Eli Lilly and Co.Disclosure: Dr. Hake has received personal compensation for activities with Eli Lilly and Company as an employee. Dr. Hake holds stock in Eli Lilly and Company. Dr. Siemers has received personal compensation for activities with Eli Lilly and Company as an employee...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hake, A., Siemers, E., Carlson, C., Estergard, W., Sundell, K., Henley, D., Eads, J., Sexton, C., Liu-Seifert, H., Sethuraman, G., Chen, Y.-F., Mintun, M., Pontecorvo, M., Joshi, A., Dean, R., Willis, B., Demattos, R., Mohs, R. Tags: P01 Aging and Dementia: Therapeutics and Clinical Trials Source Type: research

A Case Report of Dihydroergotamine Administration for Status Migrainosus in a Patient on Longstanding Citalopram Causing a Fatal Reversible Cerebral Vasoconstriction Syndrome (RCVS) (P02.027)
CONCLUSIONS: We report this case report of fatal RCVS of a patient on long standing citalopram who developed this after being administered Dihydroergotamine for status migrainosus. As this is thought to be a self-limiting in terms of clinical features. However, some patients may have more severe focal neurologic symptoms and signs, including ischemic or hemorrhagic strokes as described in our patient.Disclosure: Dr. Asi has nothing to disclose. Dr. Gomes has nothing to disclose. Dr. Dani has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Asi, K., Gomes, J., Dani, D. Tags: P02 Cerebrovascular Disease II Source Type: research

Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure
Summary: Background: Ubiquitin carboxy-terminal hydrolase (UCH-L1) has been established as a reliable and potential biomarker of neuronal damage after acute neurologic insults such as ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury. The effects of seizures on UCH-L1 levels in cerebrospinal fluid (CSF) has not been investigated in epileptic patients. The aim of the present study was to evaluate whether CSF UCH-L1 levels are a reliable marker of brain damage from epileptic seizures.Methods: Thirty-three patients with epilepsy (mean age 45 years) participated. Twenty-five patients had generalized seizures...
Source: Epilepsy Research - August 23, 2012 Category: Neurology Authors: Yajun Li, Zhenghai Wang, Bei Zhang, Xiao Zhe, Mingjue Wang, Jing Bai, Tao Lin, Shijun Zhang Tags: Research Papers Source Type: research

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