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Ticagrelor: clinical development and future potential
Rev Cardiovasc Med. 2021 Jun 30;22(2):373-394. doi: 10.31083/j.rcm2202044.ABSTRACTPlatelets participate centrally in atherothrombosis, resulting in vessel occlusion and ischaemia. Consequently, optimisation of antiplatelet regimens has the potential to further reduce the residual burden of morbidity and mortality associated with atherosclerosis. Ticagrelor is a potent oral platelet P2Y12 receptor antagonist that (1) inhibits a central amplification pathway of platelet activation directly as well as via an active metabolite, (2) has a rapid onset and offset of antiplatelet action that remains consistent in the circulation d...
Source: Reviews in Cardiovascular Medicine - July 14, 2021 Category: Cardiology Authors: Nicholas C Sanderson William A E Parker Robert F Storey Source Type: research

Redo CABG: Where Every Ounce of Experience Matters Regardless of the Technique
In this issue of Heart, Lung and Circulation, Tzoumas et  al. [1] report A Meta-Analysis of Repeat Coronary Artery Bypass Grafting comparing Off-Pump to On-Pump Techniques in a Large Cohort of Patients. They concluded that off-pump redo coronary artery bypass graft (CABG) resulted in lower perioperative death and periprocedural complication rates, and th ere was no difference observed in perioperative stroke rates and long-term survival between the two techniques. However, we commend the authors for acknowledging that there were limitations to their conclusions, thus limiting generalisation of their findings.
Source: Heart, Lung and Circulation - July 6, 2021 Category: Cardiology Authors: Adam El-Gamel Tags: Editorial Source Type: research

Bilateral Internal Thoracic Artery Grafting in Hemodialysis Patients
CONCLUSIONS: Bilateral internal thoracic artery grafting in HD patients did not improve mid-term outcomes, but it was also not associated with worse postoperative outcomes. Use of the bilateral internal thoracic artery may be an important option in patients with limited conduits to prevent postoperative complications.PMID:34176863 | DOI:10.1253/circj.CJ-21-0277
Source: Circulation Journal - June 28, 2021 Category: Cardiology Authors: Kohei Hachiro Takeshi Kinoshita Tomoaki Suzuki Tohru Asai Source Type: research

Coronary artery bypass grafting in patients with severe left ventricular systolic dysfunction: Short- and long-term outcomes
CONCLUSION: Based on our findings, coronary artery bypass grafting can be performed in patients with ischemic heart disease and severe left ventricular systolic dysfunction with acceptable hospital morbidity and mortality and long-term survival.PMID:34144786 | DOI:10.1016/j.ancard.2021.05.006
Source: Annales de Cardiologie et d'Angeiologie - June 19, 2021 Category: Cardiology Authors: M Tribak M Konat é S Saidi L Mahfoudi A Elhassani L-H Leghlimi F Lachhab N Bendagha A Soufiani J Filal A Maghraoui A Bensouda L Marmade S Moughil Source Type: research

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