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The Incidence and Predictors of Early- and Mid-Term Clinically Relevant Neurological Events After Transcatheter Aortic Valve Replacement in Real-World Patients
ConclusionsTreatment of high-risk patients with aortic stenosis using a self-expandable system was associated with a low stroke rate at short- and long-term follow-up. Multivariable predictors of clinically relevant neurological events differed on the basis of the timing after TAVR. (CoreValve Advance International Post Market Study; NCT01074658)
Source: Journal of the American College of Cardiology - July 13, 2015 Category: Cardiology Source Type: research

The Heart and the Head Neurological Implications of Transcatheter Aortic Valve Replacement ∗
In this issue of the Journal, Bosmans et al. (1) report much-awaited stroke outcomes from the ADVANCE study, a multicenter, prospective, nonrandomized cohort of patients undergoing transcatheter aortic valve replacement (TAVR) with the CoreValve prosthesis (Medtronic Inc., Minneapolis, Minnesota) at 44 mostly European sites between March 2010 and July 2011. In this real-world cohort of patients with severe aortic stenosis, the investigators observed stroke rates of 3.0% at 30 days post-TAVR and 5.6% at 2 years. They reported no significant predictors of periprocedural stroke or transient ischemic attack (TIA) occurring ...
Source: Journal of the American College of Cardiology - July 13, 2015 Category: Cardiology Source Type: research

Atrial Fibrillation and Aortic Stenosis: Impact on Clinical Outcomes Among Patients Undergoing Transcatheter Aortic Valve Implantation Structural Heart Disease
Conclusions— AF is common among high-risk patients with severe aortic stenosis undergoing transcatheter aortic valve implantation and is associated with a >2-fold increased risk of all-cause and cardiovascular mortality, irrespective of the type of AF. The gradient of risk directly correlates with the CHA2DS2–VASC score.
Source: Circulation: Cardiovascular Interventions - February 19, 2013 Category: Cardiology Authors: Stortecky, S., Buellesfeld, L., Wenaweser, P., Heg, D., Pilgrim, T., Khattab, A. A., Gloekler, S., Huber, C., Nietlispach, F., Meier, B., Juni, P., Windecker, S. Tags: Valvular heart disease, Catheter-based coronary and valvular interventions: other Structural Heart Disease Source Type: research

Sutureless aortic valves in elderly patients with aortic stenosis and intermediate-risk profile
Conclusion The use of sutureless aortic valves in elderly patients with an intermediate-risk profile provided excellent early and mid-term outcomes, providing a reliable tool in patients undergoing surgical AVR in this specific subset of population. These preliminary data need to be investigated with a TAVI control-group in further studies.
Source: Journal of Cardiovascular Medicine - March 10, 2021 Category: Cardiology Tags: Research articles: Interventions Source Type: research

Outcomes of Radial Versus Femoral Access in Patients With Severe Aortic Stenosis Undergoing Percutaneous Coronary Intervention Prior to Transcatheter Aortic Valve Replacement
CONCLUSION: Radial access for pre-TAVR PCI is feasible and safe and is associated with a lower rate of access-site hematoma. This study supports the increased use of transradial access for pre-TAVR PCI.PMID:35501112
Source: The Journal of Invasive Cardiology - May 2, 2022 Category: Cardiology Authors: Salman Farhat Abdallah El Sabbagh Mohammed Al-Hijji Keniel Pierre Nahyr S Lugo-Fagundo Yader Sandoval Michael S Gharacholou Peter M Pollak Mandeep Singh Mackram F Eleid Mohammed Al-Khouli David R Holmes Mayra Guerrero Rajiv Gulati Malcolm Bell Charanjit S Source Type: research

Surgical Aortic Valve Replacement in Very Elderly Patients Aged 80 Years and Over: Evaluation of Early Clinical Outcomes
Background: An increasing number of very elderly patients aged ≥80 years will require aortic valve replacement (AVR) for severe aortic stenosis (AS). Many are classified as high-risk surgical candidates. Transcatheter aortic valve implantation (TAVI) has been proposed as an alternative to surgical AVR (SAVR) for high-risk patients. We evaluated early clinical outcomes of very elderly patients undergoing SAVR to optimise TAVI candidate selection.Methods: We conducted a retrospective case review of 132 consecutive patients aged ≥80 years undergoing isolated SAVR (49 patients) or combined SAVR/CABG (83 patients) during Fe...
Source: Heart, Lung and Circulation - September 9, 2013 Category: Cardiology Authors: Edwin Ho, Manu N. Mathur, Peter W. Brady, David Marshman, Russell J. Brereton, Donald E. Ross, Ravinay Bhindi, Peter S. Hansen Tags: ORIGINAL ARTICLES Source Type: research

The German Aortic Valve Registry (GARY): in-hospital outcome
Conclusion The in-hospital outcome results of this registry show that conventional surgery yields excellent results in all risk groups and that catheter-based aortic valve replacements is an alternative to conventional surgery in high risk and elderly patients.
Source: European Heart Journal - June 21, 2014 Category: Cardiology Authors: Hamm, C. W., Mollmann, H., Holzhey, D., Beckmann, A., Veit, C., Figulla, H.-R., Cremer, J., Kuck, K.-H., Lange, R., Zahn, R., Sack, S., Schuler, G., Walther, T., Beyersdorf, F., Bohm, M., Heusch, G., Funkat, A.-K., Meinertz, T., Neumann, T., Papoutsis, K. Tags: FASTTRACK CLINICAL Source Type: research

Sex differences in cardiovascular outcome during progression of aortic valve stenosis
Conclusions In the SEAS study, women and men had similar rates of AS progression and AS-related events. However, women had lower total mortality and ischaemic CV event rate than men independent of confounders. Trial registration number ClinicalTrials.gov identifier: NCT00092677.
Source: Heart - January 14, 2015 Category: Cardiology Authors: Cramariuc, D., Rogge, B. P., Lonnebakken, M. T., Boman, K., Bahlmann, E., Gohlke-Barwolf, C., Chambers, J. B., Pedersen, T. R., Gerdts, E. Tags: Open access, Drugs: cardiovascular system, Echocardiography, Hypertension, Interventional cardiology, Aortic valve disease, Clinical diagnostic tests, Epidemiology Valvular heart disease Source Type: research

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