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Pre- and Perioperative Risk Factors Predicting Neurologic Outcomes after Coronary Artery Bypass Surgery in Patients with Pre-existing Neurologic Events
Conclusions: Preoperative neurologic events and advanced age are significant risk factors predicting postoperative neurologic events. Meticulous management of the ascending aorta and carotid artery are important in diminishing postoperative neurologic events. A pre-existing neurologic event is also predictive for decreased overall survival.
Source: Journal of Stroke and Cerebrovascular Diseases - February 18, 2013 Category: Neurology Authors: Isa Coskun, Yucel Colkesen, Orhan Saim Demirturk, Huseyin Ali Tunel, Semih Giray, Oner Gulcan Tags: Original Articles Source Type: research

Na(+)/H(+) exchanger in the regulation of platelet activation and paradoxical effects of cariporide.
Abstract Platelets are anucleated cell fragments derived from mature megakaryocytes and function in hemostasis when the endothelium is injured. Hemostasis involving platelets can be divided into four phases: adhesion, activation, secretion, and aggregation. Platelet activation requires a rise in intracellular Ca(2+) concentrations and results in both a morphological change and the secretion of platelet granule contents. Na(+)/H(+) exchanger isoform 1 (NHE1) regulates the intracellular pH (pHi) and the volume of platelets. In addition, NHE1 plays a large role in platelet activation. Thrombus generation involves NHE...
Source: Experimental Neurology - January 13, 2015 Category: Neurology Authors: Chang HB, Gao X, Nepomuceno R, Hu S, Sun D Tags: Exp Neurol Source Type: research

Neuroprotection After Major Cardiovascular Surgery
Opinion statement Neurologic injury is a common complication of major cardiovascular procedures including coronary artery bypass graft (CABG) surgery, coronary valve replacement, and aortic aneurysm surgery. However, despite ongoing research in the field of neuroprotection, there are currently few pharmacologic and interventional options to effectively protect the brain and spinal cord in the postoperative period. CSF drainage after aortic surgery currently stands as the only neuroprotective intervention that has been consistently shown to protect the spinal cord from ischemic injury, leading to significantly few...
Source: Current Treatment Options in Neurology - May 15, 2015 Category: Neurology Source Type: research

Transcranial Doppler Changes in Patients Treated with Extracorporeal Membrane Oxygenation
Transcranial Doppler (TCD) has significant implications for neurovascular assessment in patients being treated with venoarterial –extracorporeal membrane oxygenation (VA-ECMO). However, there have been no studies demonstrating the changes in pulsatility indices (PIs) seen in these patients. Nonpulsatile waveforms are seen during on-pump coronary artery bypass graft, but low or low–normal PIs have never been reported. It i s important to be aware of these changes, as they can be misinterpreted as cerebral vasodilation, vasoconstriction, increased intracranial pressures (ICPs), or cerebral circulatory arrest.
Source: Journal of Stroke and Cerebrovascular Diseases - August 26, 2016 Category: Neurology Authors: Tapan Kavi, Megan Esch, Brenda Rinsky, Axel Rosengart, Shouri Lahiri, Patrick D. Lyden Source Type: research

Coronary Subclavian Steal Syndrome Successfully Treated with Subclavian Artery Stenting: A Report of 2 Cases
We report 2 cases of CSSS successfully treated with subclavian artery (SA) stenting. In both cases, an Optimo balloon guiding catheter was placed in the SA immediately proximal to the vertebral artery (VA) origin as a double protection system for the VA and left internal thoracic artery (LITA) graft. There were no periprocedural complications. Balloon protection for both the VA and LITA using a single balloon guiding catheter is a reasonable and safe technique for preventing distal embolisms.
Source: Journal of Stroke and Cerebrovascular Diseases - February 1, 2017 Category: Neurology Authors: Satoshi Murai, Hisakazu Itami, Kazuhiko Nishi, Shinji Otsuka, Noboru Kusaka, Tsukasa Nishiura, Kotaro Ogihara Tags: Case Studies Source Type: research

Chapter 31 Neurologic complications of cardiac and vascular surgery
Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 141 Author(s): K.N. Sheth, E. Nourollahzadeh This chapter will provide an overview of the major neurologic complications of common cardiac and vascular surgeries, such as coronary artery bypass grafting and carotid endarterectomy. Neurologic complications after cardiac and vascular surgeries can cause significant morbidity and mortality, which can negate the beneficial effects of the intervention. Some of the complications to be discussed include ischemic and hemorrhagic stroke, seizures, delirium, cognitive dysfunction, cerebral hyperperfusion syndrome,...
Source: Handbook of Clinical Neurology - February 9, 2017 Category: Neurology Source Type: research

CT perfusion in predicting the morbidity and prognosis of hypoxic-ischemic encephalopathy after off-pump coronary artery bypass grafting.
CONCLUSION: The difference in occipital lobe rTTP on CTA perfusion may be a potential predictor of HIE. Furthermore, abnormal CT and rTTP may be used for predicting the prognosis in HIE patients. Three principal components (F1 as a reflection of CBF, F2 as reflection of TTP, F3 as a reflection of MTT) can be used to generally describe perfusion parameters. PMID: 28454490 [PubMed - as supplied by publisher]
Source: Neurological Research - May 1, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Can Moyamoya Disease Susceptibility Gene Affect Extracranial Systemic Artery Stenosis?
We report a case of a unique Japanese pedigree associated with RNF213. A 53-year-old woman with no arteriosclerotic risk factors experienced coronary artery disease, followed by coronary artery bypass surgery. In 8 years, she suffered sudden abdominal pain.
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2019 Category: Neurology Authors: Shunsuke Nomura, Yasuo Aihara, Hiroyuki Akagawa, Kentaro Chiba, Koji Yamaguchi, Akitsugu Kawashima, Yoshikazu Okada, Takakazu Kawamata Source Type: research

Incidence and Risk Factors for Silent Brain Infarction After On-Pump Cardiac Surgery: A Meta-analysis and Meta-regression of 29 Prospective Cohort Studies
ConclusionFrom the meta-regression, we concluded that advanced age and diabetes were related to increased SBI incidence after on-pump cardiac surgery, while CABG procedure alone was associated with less SBI onset. Studies with more accurate diagnoses of SBI are required to add more conclusive evidence to the field.
Source: Neurocritical Care - July 8, 2020 Category: Neurology Source Type: research

Meta-Analysis of Perioperative Stroke and Mortality in CABG Patients With Carotid Stenosis
No abstract available
Source: The Neurologist - May 1, 2021 Category: Neurology Tags: Letter to the Editor Source Type: research

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