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The effect of ultrasound for increasing neural differentiation in hBM-MSCs and inducing neurogenesis in ischemic stroke model
This study's purpose was to evaluate the effect of ultrasound in air at a frequency of 0.04MHz and an intensity of 50mW/cm2 on neural differentiation of hBM-MSCs in vitro and on neurogenesis in an ischemic stroke model. Materials and methods hBM-MSCs were exposed to 0.04MHz ultrasound and then compared with no exposed one in cell morphology, lactate dehydrogenase (LDH) activity, RT-PCR, and Western blot. In addition, we made stroke model mice by means of the photothrombosis (PT) method and these models were exposed to 0.04MHz ultrasound after hBM-MSCs injection. We compared with sham group in histological and immunohistoch...
Source: Life Sciences - August 30, 2016 Category: Biology Source Type: research

Evaluating cardiac physiology through echocardiography in bottlenose dolphins: using stroke volume and cardiac output to estimate systolic left ventricular function during rest and following exercise RESEARCH ARTICLE
S. Miedler, A. Fahlman, M. Valls Torres, T. Alvaro Alvarez, and D. Garcia-ParragaHeart-rate (fH) changes during diving and exercise are well documented for marine mammals, but changes in stroke volume (SV) and cardiac output (CO) are much less known. We hypothesized that both SV and CO are also modified following intense exercise. Using transthoracic ultrasound Doppler at the level of the aortic valve, we compared blood flow velocities in the left ventricle and cardiac frequencies during rest and at 1, 3 and 4 min after a bout of exercise in 13 adult bottlenose dolphins (Tursiops truncatus, six male and seven female, body ...
Source: Journal of Experimental Biology - September 18, 2015 Category: Biology Authors: Miedler, S., Fahlman, A., Valls Torres, M., Alvaro Alvarez, T., Garcia-Parraga, D. Tags: RESEARCH ARTICLE Source Type: research

New ultrasound device may add in detecting risk for heart attack, stroke
(North Carolina State University) Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed a new ultrasound device that could help identify arterial plaque that is at high risk of breaking off and causing heart attack or stroke.
Source: EurekAlert! - Biology - April 24, 2014 Category: Biology Source Type: news

Evaluating cardiac physiology through echocardiography in bottlenose dolphins: using stroke volume and cardiac output to estimate systolic left ventricular function during rest and following exercise RESEARCH ARTICLE
Stefan Miedler, Andreas Fahlman, Monica Valls Torres, Teresa Alvaro Alvarez, and Daniel Garcia-Parraga Heart-rate (fH) changes during diving and exercise are well documented for marine mammals, but changes in stroke volume (SV) and cardiac output (CO) are much less known. We hypothesized that both SV and CO are also modified following intense exercise. Using transthoracic ultrasound Doppler at the level of the aortic valve, we compared blood flow velocities in the left ventricle and cardiac frequencies during rest and at 1, 3 and 4 min after a bout of exercise in 13 adult bottlenose dolphins (Tursiops truncatus, six m...
Source: Journal of Experimental Biology - November 18, 2015 Category: Biology Authors: Miedler, S., Fahlman, A., Valls Torres, M., Alvaro Alvarez, T., Garcia-Parraga, D. Tags: RESEARCH ARTICLE Source Type: research

Novel Central Nervous System Drug Delivery Systems
This article is protected by copyright. All rights reserved. Novel systems of drug delivery to the central nervous system are reviewed. Multiple methods, including invasive and non‐invasive methods are examined.
Source: Chemical Biology and Drug Design - December 10, 2013 Category: Biology Authors: Jocelyn Stockwell, Nabiha Abdi, Xiaofan Lu, Oshin Maheshwari, Changiz Taghibiglou Tags: Review Source Type: research