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Specialty: Orthopaedics
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Total 80 results found since Jan 2013.

Hip fracture, comorbidity, and the risk of myocardial infarction and stroke: A Danish nationwide cohort study, 1995 ‐2015
This article is protected by copyright. All rights reserved
Source: Journal of Bone and Mineral Research - August 21, 2017 Category: Orthopaedics Authors: Alma B. Pedersen, Vera Ehrenstein, Szimonetta K. Sz épligeti, Henrik T. Sørensen Tags: Original Article Source Type: research

A predictive model of complications after spine surgery: the National Surgical Quality Improvement Program (NSQIP) 2005–2010
Conclusions: Our model can provide individualized estimates of the risks of postoperative complications based on preoperative conditions, and can potentially be used as an adjunct in decision-making for spine surgery.
Source: The Spine Journal - November 8, 2013 Category: Orthopaedics Authors: Kimon Bekelis, Atman Desai, Samuel F. Bakhoum, Symeon Missios Tags: Clinical Studies Source Type: research

New strategies for osteoporosis patients previously managed with strontium ranelate
The aim of this article is to describe potential alternatives to patients no longer eligible for management with strontium ranelate for osteoporosis according to the recommendations by the European Medicines Agency. A systematic search of Pubmed was done for papers on fracture efficacy of various treatments for osteoporosis, and potential harms especially in terms of cardiovascular events and stroke. The results showed that drugs more efficacious in terms of relative risk reduction of fractures than strontium ranelate were alendronate, risedronate, zoledronate, and denosumab. Raloxifene, as for strontium, may be associated...
Source: Therapeutic Advances in Musculoskeletal Disease - November 19, 2014 Category: Orthopaedics Authors: Vestergaard, P. Tags: Reviews Source Type: research

Post-traumatic thrombo-embolic complications in polytrauma patients
Conclusion TE complications were associated with longer ICU and hospital stay as well as a higher mortality. Overall, age and repeated operations were the most important risk factors for the development of TE events.
Source: International Orthopaedics - February 18, 2015 Category: Orthopaedics Source Type: research

Cardiovascular profile in osteoarthritis: A meta-analysis of cardiovascular events and risk factors
Conclusion: Our meta-analysis results revealed higher cardiovascular risk in OA patients. This highlights the importance of cardiovascular risk factor management in OA.
Source: Joint Bone Spine - July 17, 2019 Category: Orthopaedics Source Type: research

Estimating the incidence and key risk factors of cardiovascular disease in patients at high risk of imminent fracture using routinely collected real ‐world data from the UK
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - July 12, 2022 Category: Orthopaedics Authors: Marta Pineda ‐Moncusí, Leena El‐Hussein, Antonella Delmestri, Cyrus Cooper, Moayyeri Alireza, Cesar Libanati, Emese Toth, Daniel Prieto‐Alhambra, Sara Khalid Tags: Research Article Source Type: research

Reduced short-term complications and mortality following Enhanced Recovery primary hip and knee arthroplasty: results from 6,000 consecutive procedures.
Abstract Background and purpose Enhanced Recovery (ER) is a well-established multidisciplinary strategy in lower limb arthroplasty and was introduced in our department in May 2008. This retrospective study reviews short-term outcomes in a consecutive unselected series of 3,000 procedures (the "ER" group), and compares them to a numerically comparable cohort that had been operated on previously using a traditional protocol (the "Trad" group). Methods Prospectively collected data on surgical endpoints (length of stay (LOS), return to theater (RTT), re-admission, and 30- and 90-day mortality) and medical complication...
Source: Acta Orthopaedica - December 20, 2013 Category: Orthopaedics Authors: Khan SK, Malviya A, Muller SD, Carluke I, Partington PF, Emmerson KP, Reed MR Tags: Acta Orthop Source Type: research

Comparative evaluation of cardiovascular outcomes in patients with osteoarthritis and rheumatoid arthritis on recommended doses of nonsteroidal anti-inflammatory drugs
Conclusion: From the analysis conducted, it appears that the risk for cardiovascular events in arthritis patients on licensed doses of NSAIDs varies considerably and is likely to depend on the individual compound.
Source: Therapeutic Advances in Musculoskeletal Disease - August 4, 2014 Category: Orthopaedics Authors: Fabule, J., Adebajo, A. Tags: Original Research Source Type: research

Intraoperative hypotensive resuscitation for patients undergoing laparotomy or thoracotomy for trauma: Early termination of a randomized prospective clinical trial
Conclusion: This study was unable to demonstrate that hypotensive resuscitation at a target MAP of 50 mm Hg could significantly improve 30-day mortality. Further study is necessary to fully realize the benefits of hypotensive resuscitation. LEVEL OF EVIDENCE: Therapeutic study, level II.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - May 21, 2016 Category: Orthopaedics Tags: AAST 2015 Plenary Papers Source Type: research

What Is the Timing of General Health Adverse Events That Occur After Total Joint Arthroplasty?
CONCLUSIONS: As lengths of hospital stay after TJA continue to decrease, our findings suggest that caution is in order because several acute and immediately life-threatening findings, including myocardial infarction and pulmonary embolism, might occur after discharge. Furthermore, the timing of surgical site infection and sepsis suggests that even the 30-day followup afforded by the ACS-NSQIP may not be sufficient to study the latest occurring adverse events. Additionally, both pulmonary embolism and deep vein thrombosis tend to occur earlier after TKA than THA, and this should guide clinical surveillance efforts in patien...
Source: Clinical Orthopaedics and Related Research - January 3, 2017 Category: Orthopaedics Authors: Bohl DD, Ondeck NT, Basques BA, Levine BR, Grauer JN Tags: Clin Orthop Relat Res Source Type: research

Are Cardiac Complications Associated With Other Adverse Events? A Look at 56,000 Orthopaedic Trauma Patients.
Authors: Yarlagadda M, Shen M, Abraham A, Mousavi I, Sethi MK Abstract The purpose of this study was to identify those complications for which patients with adverse cardiac events are at risk within the 30-day postoperative period following treatment oforthopaedic trauma cases. This was a retrospective cohort study of orthopaedic trauma patients in the United States between 2006 and 2013. A total of 56,336 patients meeting any one of 89 CPT codes in the American College of Surgeons National Surgical Quality Improvement Program database were used. The main outcome measure was myocardial infarction or cardiac arrest ...
Source: Journal of surgical orthopaedic advances - November 30, 2018 Category: Orthopaedics Tags: J Surg Orthop Adv Source Type: research

Impact of marijuana on venous thromboembolic events: Cannabinoids cause clots in trauma patients
CONCLUSION THC exposure increases the risk of TEC in patients with trauma. Early identification and treatment for TEC is required to improve outcomes in this high-risk subset of trauma patients. LEVEL OF EVIDENCE Prognostic study, level III.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - June 23, 2020 Category: Orthopaedics Tags: 2020 EAST PODIUM PAPER Source Type: research

Sclerostin down ‐regulation globally by naturally occurring genetic variants, or locally in atherosclerotic plaques, does not associate with cardiovascular events in humans
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - March 19, 2021 Category: Orthopaedics Authors: Gill Holdsworth, James R Staley, Peter Hall, Ian van Koeverden, Ciara Vangjeli, Remi Okoye, Rogely Waite Boyce, James R Turk, Martin Armstrong, Alison Wolfreys, Gerard Pasterkamp Tags: Original Article Source Type: research

Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in Humans
ABSTRACTInhibition of sclerostin increases bone formation and decreases bone resorption, leading to increased bone mass, bone mineral density, and bone strength and reduced fracture risk. In a clinical study of the sclerostin antibody romosozumab versus alendronate in postmenopausal women (ARCH), an imbalance in adjudicated serious cardiovascular (CV) adverse events driven by an increase in myocardial infarction (MI) and stroke was observed. To explore whether there was a potential mechanistic plausibility that sclerostin expression, or its inhibition, in atherosclerotic (AS) plaques may have contributed to this imbalance,...
Source: Journal of Bone and Mineral Research - March 30, 2021 Category: Orthopaedics Authors: Gill Holdsworth, James R Staley, Peter Hall, Ian Koeverden, Ciara Vangjeli, Remi Okoye, Rogely W Boyce, James R Turk, Martin Armstrong, Alison Wolfreys, Gerard Pasterkamp Tags: Original Article Source Type: research